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NTRK fusion-positive cancers and TRK inhibitor therapy

Nature reviews. Clinical oncology, 2018-12, Vol.15 (12), p.731-747

2018

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Targeting TRK family proteins in cancer

Pharmacology & therapeutics (Oxford), 2017-05, Vol.173, p.58-66

2017

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Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

Nature communications, 2020-04, Vol.11 (1), p.1950-1950, Article 1950

2020

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TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice

Nature communications, 2022-02, Vol.13 (1), p.914-17, Article 914

2022

Volltextzugriff (PDF)

Truncated TrkB: Beyond a dominant negative receptor

Cytokine & growth factor reviews, 2012-02, Vol.23 (1), p.15-24

Fenner, Barbara M

2012

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Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (7)

2022

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Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor

The Journal of biological chemistry, 2014-10, Vol.289 (40), p.27571-27584

2014

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Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization

Nature communications, 2020-08, Vol.11 (1), p.3935-3935, Article 3935

2020

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Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (18), p.9094-9102

2019

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Glioma synapses recruit mechanisms of adaptive plasticity

Nature (London), 2023-11, Vol.623 (7986), p.366-374

2023

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ESMO recommendations on the standard methods to detect NTRK fusions in daily practice and clinical research

Annals of oncology, 2019-09, Vol.30 (9), p.1417-1427

2019

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STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury

Nature cell biology, 2020-10, Vol.22 (10), p.1197

2020

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TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

Nature communications, 2017-11, Vol.8 (1), p.1668-14, Article 1668

2017

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Engeletin alleviates depression‐like phenotype by increasing synaptic plasticity via the BDNF‐TrkB‐mTORC1 signalling pathway

Journal of cellular and molecular medicine, 2023-12, Vol.27 (23), p.3928-3938

2023

Volltextzugriff (PDF)

Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (30), p.E7023-E7032

2018

Volltextzugriff (PDF)

Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.1731-1760

2019

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Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

The international journal of neuropsychopharmacology, 2015-02, Vol.18 (4), p.1-12

2015

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Therapeutic Potentials of BDNF/TrkB in Breast Cancer; Current Status and Perspectives

Journal of cellular biochemistry, 2017-09, Vol.118 (9), p.2502-2515

2017

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Immunity against cancer cells may promote their proliferation and metastasis

Proceedings of the National Academy of Sciences - PNAS, 2020-01, Vol.117 (1), p.426-431

2020

Volltextzugriff (PDF)

selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (6), p.2687-2692

2010

Volltextzugriff (PDF)

Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease

Neuron (Cambridge, Mass.), 2014-07, Vol.83 (1), p.178-188

2014

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TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease

Proceedings of the National Academy of Sciences - PNAS, 2017-10, Vol.114 (40), p.10773-10778

2017

Volltextzugriff (PDF)

Neuronal plasticity and neurotrophic factors in drug responses

Molecular psychiatry, 2017-08, Vol.22 (8), p.1085-1095

2017

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Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

Nature communications, 2017-08, Vol.8 (1), p.195-13, Article 195

2017

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NTRK fusion-positive cancers and TRK inhibitor therapy

Targeting TRK family proteins in cancer

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Truncated TrkB: Beyond a dominant negative receptor

Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome

Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor

Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization

Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies

Glioma synapses recruit mechanisms of adaptive plasticity

ESMO recommendations on the standard methods to detect NTRK fusions in daily practice and clinical research

STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury

TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

Engeletin alleviates depression‐like phenotype by increasing synaptic plasticity via the BDNF‐TrkB‐mTORC1 signalling pathway

Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library

Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application

Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Therapeutic Potentials of BDNF/TrkB in Breast Cancer; Current Status and Perspectives

Immunity against cancer cells may promote their proliferation and metastasis

selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease

TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease

Neuronal plasticity and neurotrophic factors in drug responses

Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

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