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Synthesis and evaluation of antibody-drug conjugates with high drug-to-antibody ratio using dimaleimide-DM1 as a linker- payload

Bioorganic chemistry, 2024-08, Vol.149, p.107504, Article 107504

2024

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A bioorthogonal system reveals antitumour immune function of pyroptosis

Nature (London), 2020-03, Vol.579 (7799), p.421-426

2020

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Trastuzumab Deruxtecan: First Approval

Drugs (New York, N.Y.), 2020-04, Vol.80 (5), p.501-508

Keam, Susan J.

2020

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A HER2-Targeting Antibody-Drug Conjugate, Trastuzumab Deruxtecan (DS-8201a), Enhances Antitumor Immunity in a Mouse Model

Molecular cancer therapeutics, 2018-07, Vol.17 (7), p.1494-1503

2018

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High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Bioconjugate chemistry, 2018-02, Vol.29 (2), p.473-485

2018

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Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

ACS chemical biology, 2020-06, Vol.15 (6), p.1306-1312

2020

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An Eighteen‐Membered Macrocyclic Ligand for Actinium‐225 Targeted Alpha Therapy

Angewandte Chemie International Edition, 2017-11, Vol.56 (46), p.14712-14717

International ed. in English, 2017

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Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface

Nature (London), 2021-12, Vol.600 (7888), p.339-343

2021

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In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2020-06, Vol.185, p.113218-113218, Article 113218

2020

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Polyglycerol-Shelled Reduction-Sensitive Polymersome for DM1 Delivery to HER-2-Positive Breast Cancer

Biomacromolecules, 2024-07, Vol.25 (7), p.4440-4448

2024

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Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

Nature biomedical engineering, 2021-06, Vol.5 (6), p.600-612

2021

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Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N‑Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates

Bioconjugate chemistry, 2015-11, Vol.26 (11), p.2233-2242

2015

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Site-Specific Chemical Conjugation of Antibodies by Using Affinity Peptide for the Development of Therapeutic Antibody Format

Bioconjugate chemistry, 2019-03, Vol.30 (3), p.698-702

2019

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Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer

Scientific reports, 2016-04, Vol.6 (1), p.23179, Article 23179

2016

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A dual-enzyme cleavable linker for antibody-drug conjugates

Chemical communications (Cambridge, England), 2021-04, Vol.57 (28), p.3457-346

2021

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Mitigating In-Column Artificial Modifications in High-Temperature LC–MS for Bottom–Up Proteomics and Quality Control of Protein Biopharmaceuticals

Analytical chemistry (Washington), 2024-09, Vol.96 (36), p.14531-14540

2024

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Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (6), p.1542-1545

2016

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Potential of hydrophilic interaction chromatography for the analytical characterization of protein biopharmaceuticals

Journal of Chromatography A, 2016-05, Vol.1448, p.81-92

2016

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Site-Directed Electrochemical Grafting for Amplified Detection of Antibody Pharmaceuticals

Analytical chemistry (Washington), 2024-06, Vol.96 (22), p.9278-9284

2024

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Highly Potent, Anthracycline-based Antibody-Drug Conjugates Generated by Enzymatic, Site-specific Conjugation

Molecular cancer therapeutics, 2017-05, Vol.16 (5), p.879-892

2017

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Systematic Preparation of a 66-IgG Library with Symmetric and Asymmetric Homogeneous Glycans and Their Functional Evaluation

Journal of the American Chemical Society, 2024-08, Vol.146 (33), p.23426-23436

2024

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Site-Specific Dolasynthen Antibody-Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios

Molecular cancer therapeutics, 2024-01, Vol.23 (1), p.84-91

2024

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Human Epidermal Growth Factor Receptor 2 (HER2) in Advanced Gastric Cancer: Current Knowledge and Future Perspectives

Drugs (New York, N.Y.), 2020-03, Vol.80 (4), p.401-415

2020

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A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

Nature communications, 2015-03, Vol.6 (1), p.6645, Article 6645

2015

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A common glycan structure on immunoglobulin G for enhancement of effector functions

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (34), p.10611-10616

2015

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Synthesis and evaluation of antibody-drug conjugates with high drug-to-antibody ratio using dimaleimide-DM1 as a linker- payload

A bioorthogonal system reveals antitumour immune function of pyroptosis

Trastuzumab Deruxtecan: First Approval

A HER2-Targeting Antibody-Drug Conjugate, Trastuzumab Deruxtecan (DS-8201a), Enhances Antitumor Immunity in a Mouse Model

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

An Eighteen‐Membered Macrocyclic Ligand for Actinium‐225 Targeted Alpha Therapy

Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface

In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry

Polyglycerol-Shelled Reduction-Sensitive Polymersome for DM1 Delivery to HER-2-Positive Breast Cancer

Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N‑Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates

Site-Specific Chemical Conjugation of Antibodies by Using Affinity Peptide for the Development of Therapeutic Antibody Format

Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer

A dual-enzyme cleavable linker for antibody-drug conjugates

Mitigating In-Column Artificial Modifications in High-Temperature LC–MS for Bottom–Up Proteomics and Quality Control of Protein Biopharmaceuticals

Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads

Potential of hydrophilic interaction chromatography for the analytical characterization of protein biopharmaceuticals

Site-Directed Electrochemical Grafting for Amplified Detection of Antibody Pharmaceuticals

Highly Potent, Anthracycline-based Antibody-Drug Conjugates Generated by Enzymatic, Site-specific Conjugation

Systematic Preparation of a 66-IgG Library with Symmetric and Asymmetric Homogeneous Glycans and Their Functional Evaluation

Site-Specific Dolasynthen Antibody-Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios

Human Epidermal Growth Factor Receptor 2 (HER2) in Advanced Gastric Cancer: Current Knowledge and Future Perspectives

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

A common glycan structure on immunoglobulin G for enhancement of effector functions

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