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N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation

European journal of medicinal chemistry, 2021-12, Vol.226, p.113817-113817, Article 113817

2021

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Etirinotecan Pegol (NKTR-102) in Third-line Treatment of Patients With Metastatic or Recurrent Non–Small-cell Lung Cancer: Results of a Phase II Study

Clinical lung cancer, 2018-03, Vol.19 (2), p.157-162

2018

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Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys

Xenobiotica, 2019-09, Vol.49 (9), p.1086-1096

2019

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Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor

European journal of medicinal chemistry, 2017-02, Vol.127, p.318-333

2017

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Targeting Topoisomerase I in the Era of Precision Medicine

Clinical cancer research, 2019-11, Vol.25 (22), p.6581-6589

2019

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Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities

European journal of medicinal chemistry, 2017-02, Vol.127, p.235-249

2017

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Irinotecan-Still an Important Player in Cancer Chemotherapy: A Comprehensive Overview

International journal of molecular sciences, 2020-07, Vol.21 (14), p.4919

2020

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Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: Synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity

European journal of medicinal chemistry, 2013-11, Vol.69, p.427-438

2013

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Topoisomerase Enzyme Inhibitors as Potential Drugs Against Cancer: What Makes Them Selective or Dual? - A Review

Current pharmaceutical design, 2022-01, Vol.28 (34), p.2800

2022

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Design, Synthesis, and Investigation of the Pharmacokinetics and Anticancer Activities of Indenoisoquinoline Derivatives That Stabilize the G‑Quadruplex in the MYC Promoter and Inhibit Topoisomerase I

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7006-7032

2024

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Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs

Current medicinal chemistry, 2010-12, Vol.17 (35), p.4270

2010

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Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors

European journal of medicinal chemistry, 2015-03, Vol.92, p.540-553

2015

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Inhibition of human topoisomerase I and II and anti-proliferative effects on MCF-7 cells by new titanocene complexes

Bioorganic & medicinal chemistry, 2015-11, Vol.23 (22), p.7302-7312

2015

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Dual topoisomerase I and II poisoning by chiral Ru(II) complexes containing 2-thiophenylimidazo[4,5-f][1,10]phenanthroline derivatives

Journal of inorganic biochemistry, 2014-01, Vol.130, p.15-27

2014

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Recent Developments in Combination Chemotherapy for Colorectal and Breast Cancers with Topoisomerase Inhibitors

International journal of molecular sciences, 2023-05, Vol.24 (9), p.8457

2023

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Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents

Journal of medicinal chemistry, 2015-08, Vol.58 (16), p.6678-6696

2015

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Synthesis of Methoxy‑, Methylenedioxy‑, Hydroxy‑, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

Journal of medicinal chemistry, 2021-06, Vol.64 (11), p.7617-7629

2021

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DNA topoisomerase I and DNA gyrase as targets for TB therapy

Drug discovery today, 2017-03, Vol.22 (3), p.510-518

2017

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Belotecan for relapsing small-cell lung cancer patients initially treated with an irinotecan-containing chemotherapy: A phase II trial

Lung cancer (Amsterdam, Netherlands), 2010-10, Vol.70 (1), p.77-81

2010

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Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

Journal of controlled release, 2017-02, Vol.247, p.28-54

2017

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Topoisomerase as target for antibacterial and anticancer drug discovery

Journal of enzyme inhibition and medicinal chemistry, 2013-06, Vol.28 (3), p.419-435

2013

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Structural simplification of evodiamine: Discovery of novel tetrahydro-β-carboline derivatives as potent antitumor agents

Bioorganic & medicinal chemistry letters, 2021-05, Vol.40, p.127954, Article 127954

2021

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Synthesis of novel hybrid quinolino[4,3-b][1,5]naphthyridines and quinolino[4,3-b][1,5]naphthyridin-6(5H)-one derivatives and biological evaluation as topoisomerase I inhibitors and antiproliferatives

European journal of medicinal chemistry, 2020-06, Vol.195, p.112292, Article 112292

2020

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Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (4), p.566-571

2018

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Chiral ruthenium(II) anthraquinone complexes as dual inhibitors of topoisomerases I and II

Journal of biological inorganic chemistry, 2012, Vol.17 (1), p.81-96

2012

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