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Exploring traditional and nontraditional roles for thrombomodulin

Blood, 2018-07, Vol.132 (2), p.148-158

2018

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Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

Cancer letters, 2021-01, Vol.497, p.1-13

2021

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Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects

American journal of physiology. Heart and circulatory physiology, 2013-06, Vol.304 (12), p.H1585-H1597

2013

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Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

Nature communications, 2016-04, Vol.7 (1), p.11138-10, Article 11138

2016

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Sustained release of recombinant thrombomodulin from cross-linked gelatin/hyaluronic acid hydrogels potentiate wound healing in diabetic mice

European journal of pharmaceutics and biopharmaceutics, 2019-02, Vol.135, p.61-71

2019

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Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential

Critical care (London, England), 2019-08, Vol.23 (1), p.280-280, Article 280

2019

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COMBINATION THERAPY WITH A SENSE OLIGONUCLEOTIDE TO INDUCIBLE NITRIC OXIDE SYNTHASE MRNA AND HUMAN SOLUBLE THROMBOMODULIN IMPROVES SURVIVAL OF SEPSIS MODEL RATS AFTER PARTIAL HEPATECTOMY

Shock (Augusta, Ga.), 2023-07, Vol.60 (1), p.84-91

2023

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Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression

Blood, 2021-02, Vol.137 (7), p.977-982

2021

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Thrombomodulin and its role in inflammation

Seminars in immunopathology, 2012-01, Vol.34 (1), p.107-125

Conway, Edward M.

2012

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Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs

Transplantation, 2014-01, Vol.97 (2), p.138-147

2014

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Recombinant and chemo-/bio-orthogonal synthesis of liposomal thrombomodulin and its antithrombotic activity

Journal of bioscience and bioengineering, 2017-10, Vol.124 (4), p.445-451

2017

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Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial

JAMA : the journal of the American Medical Association, 2019-10, Vol.322 (13), p.1261

2019

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Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1α-VEGF pathway

Cellular and molecular life sciences : CMLS, 2021-12, Vol.78 (23), p.7681-7692

2021

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Recombinant thrombomodulin prevents acute lung injury induced by renal ischemia-reperfusion injury

Scientific reports, 2020-01, Vol.10 (1), p.289-289, Article 289

2020

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Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin

Arteriosclerosis, thrombosis, and vascular biology, 2024-03, Vol.44 (3), p.603-616

2024

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C‐type lectin domain group 14 proteins in vascular biology, cancer and inflammation

The FEBS journal, 2019-09, Vol.286 (17), p.3299-3332

2019

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Thrombomodulin Regulates PTEN/AKT Signaling Axis in Endothelial Cells

Arteriosclerosis, thrombosis, and vascular biology, 2024-02, Vol.44 (2), p.352-365

2024

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Recombinant Thrombomodulin Has Anti-tumor Effects and Enhances the Effects of Gemcitabine for Pancreatic Cancer Through G-protein Coupled Receptor 15

Anticancer research, 2022-10, Vol.42 (10), p.4679-4687

2022

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Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

Xenotransplantation (Københaven), 2019-07, Vol.26 (4), p.e12516-n/a

2019

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Ser252Asn Mutation Introduces a New N-Linked Glycosylation Site and Causes Type IIb Protein C Deficiency

Thrombosis and haemostasis, 2024-05, Vol.124 (5), p.459-470

2024

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Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain-Brief Report

Arteriosclerosis, thrombosis, and vascular biology, 2020-12, Vol.40 (12), p.2837-2844

2020

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Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial

JAMA : the journal of the American Medical Association, 2019-05, Vol.321 (20), p.1993

2019

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Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia‐reperfusion injury

The FASEB journal, 2017-02, Vol.31 (2), p.761-770

2017

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Recombinant human thrombomodulin attenuated sepsis severity in a non-surgical preterm mouse model

Scientific reports, 2020-01, Vol.10 (1), p.333, Article 333

2020

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Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

The Journal of thoracic and cardiovascular surgery, 2014-09, Vol.148 (3), p.1106-1114

2014

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Exploring traditional and nontraditional roles for thrombomodulin

Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

Sustained release of recombinant thrombomodulin from cross-linked gelatin/hyaluronic acid hydrogels potentiate wound healing in diabetic mice

Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential

COMBINATION THERAPY WITH A SENSE OLIGONUCLEOTIDE TO INDUCIBLE NITRIC OXIDE SYNTHASE MRNA AND HUMAN SOLUBLE THROMBOMODULIN IMPROVES SURVIVAL OF SEPSIS MODEL RATS AFTER PARTIAL HEPATECTOMY

Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression

Thrombomodulin and its role in inflammation

Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs

Recombinant and chemo-/bio-orthogonal synthesis of liposomal thrombomodulin and its antithrombotic activity

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial

Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1α-VEGF pathway

Recombinant thrombomodulin prevents acute lung injury induced by renal ischemia-reperfusion injury

Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin

C‐type lectin domain group 14 proteins in vascular biology, cancer and inflammation

Thrombomodulin Regulates PTEN/AKT Signaling Axis in Endothelial Cells

Recombinant Thrombomodulin Has Anti-tumor Effects and Enhances the Effects of Gemcitabine for Pancreatic Cancer Through G-protein Coupled Receptor 15

Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

Ser252Asn Mutation Introduces a New N-Linked Glycosylation Site and Causes Type IIb Protein C Deficiency

Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain-Brief Report

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial

Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia‐reperfusion injury

Recombinant human thrombomodulin attenuated sepsis severity in a non-surgical preterm mouse model

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

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