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Crosstalk between TPC2 and IP3R regulates Ca2+ signals

Trends in cell biology, 2024-05, Vol.34 (5), p.352-354

2024

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Lysosomal Physiology

Annual review of physiology, 2015-01, Vol.77 (1), p.57-80

2015

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Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know

Cell calcium (Edinburgh), 2022-05, Vol.103, p.102543-102543, Article 102543

2022

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Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1

Cell calcium (Edinburgh), 2023-12, Vol.116, p.102801-102801, Article 102801

2023

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Deletion of Dictyostelium tpc2 gene forms multi‐tipped structures, regulates autophagy and cell‐type patterning

Biology of the cell, 2024-05, Vol.116 (5), p.e2300067-n/a

2024

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Delivery of plasmid DNA into pre‐osteoclast‐like and mature osteoclast‐like cells using cationic peptides

Journal of Osaka Dental University, 2021/10/25, Vol.55(2), pp.239-243

2021

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An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Cell reports (Cambridge), 2017-02, Vol.18 (7), p.1636-1645

2017

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TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann–Pick type C1, and Batten disease

EMBO molecular medicine, 2022-09, Vol.14 (9), p.e15377-n/a

2022

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PI(3,5)P2 and NAADP: Team players or lone warriors? – New insights into TPC activation modes

Cell calcium (Edinburgh), 2023-01, Vol.109, p.102675, Article 102675

2023

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Lysosomal Ion Channels as Decoders of Cellular Signals

Trends in biochemical sciences (Amsterdam. Regular ed.), 2019-02, Vol.44 (2), p.110-124

2019

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Dysregulation of host cell calcium signaling during viral infections: Emerging paradigm with high clinical relevance

Molecular aspects of medicine, 2021-10, Vol.81, p.101004-101004, Article 101004

2021

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Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers

Biochimica et biophysica acta. Molecular cell research, 2019-07, Vol.1866 (7), p.1151-1161

2019

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Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function

Frontiers in pharmacology, 2017-02, Vol.8, p.45-45

2017

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Coordinating activation of endo‐lysosomal two‐pore channels and TRP mucolipins

The Journal of physiology, 2024-04, Vol.602 (8), p.1623-1636

2024

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TPC2 gating: Trying to break the enigma code

Cell calcium (Edinburgh), 2023-12, Vol.116, p.102815, Article 102815

2023

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JPT2: The missing link between intracellular Ca2+ release channels and NAADP?

Cell calcium (Edinburgh), 2021-07, Vol.97, p.102405, Article 102405

2021

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Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

The EMBO journal, 2014-03, Vol.33 (5), p.501-511

2014

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NAADP/TPC2/Ca(2+) Signaling Inhibits Autophagy

Communicative & integrative biology, 2013-11, Vol.6 (6), p.e27595-e27595

2013

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TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

Proceedings of the National Academy of Sciences - PNAS, 2017-10, Vol.114 (41), p.E8595-E8602

2017

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The protein interaction networks of mucolipins and two-pore channels

Biochimica et biophysica acta. Molecular cell research, 2019-07, Vol.1866 (7), p.1111-1123

2019

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TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells

Experimental cell research, 2018-09, Vol.370 (2), p.478-489

2018

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Oocyte electroporation prior to in vitro fertilization is an efficient method to generate single, double, and multiple knockout porcine embryos of interest in biomedicine and animal production

Theriogenology, 2024-04, Vol.218, p.111-118

2024

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The ion channels of endomembranes

Physiological reviews, 2024-07, Vol.104 (3), p.1335-1385

2024

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Discovery of lipophilic two‐pore channel agonists

The FEBS journal, 2020-12, Vol.287 (24), p.5284-5293

2020

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Crosstalk between TPC2 and IP3R regulates Ca2+ signals

Lysosomal Physiology

Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know

Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1

Deletion of Dictyostelium tpc2 gene forms multi‐tipped structures, regulates autophagy and cell‐type patterning

Delivery of plasmid DNA into pre‐osteoclast‐like and mature osteoclast‐like cells using cationic peptides

An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann–Pick type C1, and Batten disease

PI(3,5)P2 and NAADP: Team players or lone warriors? – New insights into TPC activation modes

Lysosomal Ion Channels as Decoders of Cellular Signals

Dysregulation of host cell calcium signaling during viral infections: Emerging paradigm with high clinical relevance

Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

Coordinating activation of endo‐lysosomal two‐pore channels and TRP mucolipins

TPC2 gating: Trying to break the enigma code

JPT2: The missing link between intracellular Ca2+ release channels and NAADP?

Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

NAADP/TPC2/Ca(2+) Signaling Inhibits Autophagy

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

The protein interaction networks of mucolipins and two-pore channels

TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells

Oocyte electroporation prior to in vitro fertilization is an efficient method to generate single, double, and multiple knockout porcine embryos of interest in biomedicine and animal production

The ion channels of endomembranes

Discovery of lipophilic two‐pore channel agonists

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