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Insights into the function and regulation of the calcium-activated chloride channel TMEM16A

Cell calcium (Edinburgh), 2024-07, Vol.121, p.102891-102891, Article 102891

2024

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Structural and theoretical basis for drug development targeting TMEM16A: Inhibition mechanism of tracheloside analogs

International journal of biological macromolecules, 2024-10, Vol.277 (Pt 2), p.134057, Article 134057

2024

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Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A

International journal of molecular sciences, 2020-04, Vol.21 (7), p.2557

2020

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Exploring the potential of cryptochlorogenic acid as a dietary adjuvant for multi-target combined lung cancer treatment

Phytomedicine (Stuttgart), 2024-09, Vol.132, p.155907, Article 155907

2024

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Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects

Pharmacological research, 2020-06, Vol.156, p.104763-104763, Article 104763

2020

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TMEM16A Plays an Insignificant Role in Myocardium Remodeling but May Promote Angiogenesis of Heart During Pressure-overload

Frontiers in physiology, 2022-05, Vol.13, p.897619-897619

2022

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The multifaceted role of TMEM16A in cancer

Cell calcium (Edinburgh), 2019-09, Vol.82, p.102050-102050, Article 102050

2019

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Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A)

Handbook of experimental pharmacology, 2024, Vol.283, p.101

2024

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Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor–transmembrane protein 16A–voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma

Journal of allergy and clinical immunology, 2018-04, Vol.141 (4), p.1259-1268.e11

2018

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Red ginseng aqueous extract improves mucociliary transport dysfunction and histopathology in CF rat airways

Journal of cystic fibrosis, 2023-11, Vol.22 (6), p.1113-1119

2023

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Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling

Frontiers in physiology, 2020-11, Vol.11, p.590262-590262

Dulin, Nickolai O

2020

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Potent vasorelaxant activity of the TMEM16A inhibitor T16A inh ‐A01

British journal of pharmacology, 2013-02, Vol.168 (3), p.773-784

2013

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TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium

Frontiers in physiology, 2023-05, Vol.14, p.1157704-1157704

2023

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TMEM16A deficiency in alveolar type 2 epithelial cells protected against endoplasmic reticulum stress-induced ferroptosis during acute lung injury

International immunopharmacology, 2023-12, Vol.125, p.111208-111208, Article 111208

2023

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TMEM16A ion channel: A novel target for cancer treatment

Life sciences (1973), 2023-10, Vol.331, p.122034-122034, Article 122034

2023

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Alternative chloride transport pathways as pharmacological targets for the treatment of cystic fibrosis

Journal of cystic fibrosis, 2020-03, Vol.19, p.S37-S41

2020

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The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model

The FASEB journal, 2021-10, Vol.35 (10), p.e21897-n/a

2021

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Increased TMEM16A-mediated Ca2+-activated Cl- currents in portal vein smooth muscle cells of caveolin 1-deficient mice

Biological and Pharmaceutical Bulletin, 2022, pp.b22-00514

2022

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Anoctamin 1, a multi-modal player in pain and itch

Cell calcium (Edinburgh), 2024-11, Vol.123, p.102924, Article 102924

2024

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Smooth muscle-specific TMEM16A expression protects against angiotensin II-induced cerebrovascular remodeling via suppressing extracellular matrix deposition

Journal of molecular and cellular cardiology, 2019-09, Vol.134, p.131-143

2019

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Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl− channels

Journal of pharmacological sciences, 2021-05, Vol.146 (1), p.65-69

2021

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TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Frontiers in pharmacology, 2019, Vol.10, p.3-3

2019

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Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

Journal of the American Society of Nephrology, 2019-02, Vol.30 (2), p.228-242

2019

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WNK kinase, ion channels and arachidonic acid metabolites choreographically execute endothelium-dependent vasodilation

Cell calcium (Edinburgh), 2024-07, Vol.121, p.102904-102904, Article 102904

Arreola, Jorge

2024

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Insights into the function and regulation of the calcium-activated chloride channel TMEM16A

Structural and theoretical basis for drug development targeting TMEM16A: Inhibition mechanism of tracheloside analogs

Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A

Exploring the potential of cryptochlorogenic acid as a dietary adjuvant for multi-target combined lung cancer treatment

Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects

TMEM16A Plays an Insignificant Role in Myocardium Remodeling but May Promote Angiogenesis of Heart During Pressure-overload

The multifaceted role of TMEM16A in cancer

Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A)

Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor–transmembrane protein 16A–voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma

Red ginseng aqueous extract improves mucociliary transport dysfunction and histopathology in CF rat airways

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling

Potent vasorelaxant activity of the TMEM16A inhibitor T16A inh ‐A01

TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium

TMEM16A deficiency in alveolar type 2 epithelial cells protected against endoplasmic reticulum stress-induced ferroptosis during acute lung injury

TMEM16A ion channel: A novel target for cancer treatment

Alternative chloride transport pathways as pharmacological targets for the treatment of cystic fibrosis

The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model

Increased TMEM16A-mediated Ca2+-activated Cl- currents in portal vein smooth muscle cells of caveolin 1-deficient mice

Anoctamin 1, a multi-modal player in pain and itch

Smooth muscle-specific TMEM16A expression protects against angiotensin II-induced cerebrovascular remodeling via suppressing extracellular matrix deposition

Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl− channels

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

WNK kinase, ion channels and arachidonic acid metabolites choreographically execute endothelium-dependent vasodilation

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