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Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

Nature structural & molecular biology, 2021-03, Vol.28 (3), p.319

2021

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Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities

Scientific reports, 2020-02, Vol.10 (1), p.3490-3490, Article 3490

2020

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Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages

International immunopharmacology, 2023-07, Vol.120, p.110295-110295, Article 110295

2023

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Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue

Bioorganic & medicinal chemistry, 2023-09, Vol.92, p.117424-117424, Article 117424

2023

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Suramin inhibits phenotypic transformation of vascular smooth muscle cells and neointima hyperplasia by suppressing transforming growth factor beta receptor 1 /Smad2/3 pathway activation

European journal of pharmacology, 2024-04, Vol.968, p.176422-176422, Article 176422

2024

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Impact of Suramin on Key Pathological Features of Sporadic Alzheimer's Disease-Derived Forebrain Neurons

Journal of Alzheimer's disease, 2024-01, Vol.98 (1), p.301

2024

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Using Covalent Labeling and Mass Spectrometry To Study Protein Binding Sites of Amyloid Inhibiting Molecules

Analytical chemistry (Washington), 2017-11, Vol.89 (21), p.11583-11591

2017

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Structure-Based Inhibition of Norovirus RNA-Dependent RNA Polymerases

Journal of molecular biology, 2012-06, Vol.419 (3-4), p.198-210

2012

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Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds

PloS one, 2014-03, Vol.9 (3), p.e91765

2014

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First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis

Metabolomics, 2024-02, Vol.20 (2), p.25-25, Article 25

2024

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Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes

Pflügers Archiv, 2022-05, Vol.474 (5), p.553-565

2022

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The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1

The Journal of biological chemistry, 2019-09, Vol.294 (37), p.13740-13754

2019

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HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules

Bioorganic & medicinal chemistry letters, 2019-05, Vol.29 (9), p.1106-1112

2019

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Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A

Scientific reports, 2017-02, Vol.7 (1), p.42902-42902, Article 42902

2017

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Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid Protein in Complex with Suramin Reveals Therapeutic Potential

Journal of Virology, 2013-06, Vol.87 (12), p.6829-6839

2013

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Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei

Molecular microbiology, 2018-01, Vol.107 (1), p.57-67

2018

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Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by Suramin

Structure (London), 2007-03, Vol.15 (3), p.377-389

2007

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Protein–Ligand Interaction Energy-Based Entropy Calculations: Fundamental Challenges For Flexible Systems

The journal of physical chemistry. B, 2018-08, Vol.122 (32), p.7821-7827

2018

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Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway

Drug design, development and therapy, 2022-01, Vol.16, p.1107-1120

2022

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Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery

Journal of antimicrobial chemotherapy, 2014-07, Vol.69 (7), p.1834-1843

2014

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ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex

Brain research bulletin, 2017-10, Vol.135, p.129-142

2017

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Effects of Stromal Cell Conditioned Medium and Antipurinergic Treatment on Macrophage Phenotype

Tissue engineering. Part C, Methods, 2022-12, Vol.28 (12), p.656

2022

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Chemerin, a Novel Adipokine in the Regulation of Angiogenesis

The journal of clinical endocrinology and metabolism, 2010-05, Vol.95 (5), p.2476-2485

2010

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Electrostatic Tuning of Anion Attraction from the Cytoplasm to the Pore of the CFTR Chloride Channel

Cell biochemistry and biophysics, 2020-03, Vol.78 (1), p.15-22

2020

Volltextzugriff (PDF)

A dual drug regimen synergistically blocks human parainfluenza virus infection

Scientific reports, 2016-04, Vol.6 (1), p.24138-24138, Article 24138

2016

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Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities

Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages

Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue

Suramin inhibits phenotypic transformation of vascular smooth muscle cells and neointima hyperplasia by suppressing transforming growth factor beta receptor 1 /Smad2/3 pathway activation

Impact of Suramin on Key Pathological Features of Sporadic Alzheimer's Disease-Derived Forebrain Neurons

Using Covalent Labeling and Mass Spectrometry To Study Protein Binding Sites of Amyloid Inhibiting Molecules

Structure-Based Inhibition of Norovirus RNA-Dependent RNA Polymerases

Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds

First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis

Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes

The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1

HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules

Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A

Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid Protein in Complex with Suramin Reveals Therapeutic Potential

Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei

Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by Suramin

Protein–Ligand Interaction Energy-Based Entropy Calculations: Fundamental Challenges For Flexible Systems

Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway

Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery

ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex

Effects of Stromal Cell Conditioned Medium and Antipurinergic Treatment on Macrophage Phenotype

Chemerin, a Novel Adipokine in the Regulation of Angiogenesis

Electrostatic Tuning of Anion Attraction from the Cytoplasm to the Pore of the CFTR Chloride Channel

A dual drug regimen synergistically blocks human parainfluenza virus infection

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