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Sulindac‐derived retinoid X receptor‐α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE−/− mice

British journal of pharmacology, 2019-07, Vol.176 (14), p.2559-2572

2019

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Phospho-Sulindac (OXT-328) Inhibits Dry Eye Disease in Rabbits: A Dose-, Formulation- and Structure-Dependent Effect

Journal of ocular pharmacology and therapeutics, 2021-07, Vol.37 (6), p.321-330

2021

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Diverse amide analogs of sulindac for cancer treatment and prevention

Bioorganic & medicinal chemistry letters, 2017-10, Vol.27 (20), p.4614-4621

2017

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Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2

Biochemical and biophysical research communications, 2018-11, Vol.505 (4), p.1203-1210

2018

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A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity

Cancer prevention research (Philadelphia, Pa.), 2009-06, Vol.2 (6), p.572-580

2009

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The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase

FEBS letters, 2012-01, Vol.586 (1), p.55-59

2012

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Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis

Oncogene, 2017-08, Vol.36 (32), p.4597-4609

2017

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Novel sulindac derivatives: synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activity

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.921-934

2020

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Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

The Journal of clinical investigation, 2017-08, Vol.127 (8), p.3167-3176

2017

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Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

Molecular cancer therapeutics, 2009-12, Vol.8 (12), p.3331-3340

2009

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Anti-tumor activity of non-steroidal anti-inflammatory drugs: Cyclooxygenase-independent targets

Cancer letters, 2014-05, Vol.346 (2), p.217-224

2014

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An experimentally validated approach to automated biological evidence generation in drug discovery using knowledge graphs

Nature communications, 2024-07, Vol.15 (1), p.5703-16, Article 5703

2024

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Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Nature communications, 2019-04, Vol.10 (1), p.1463-15, Article 1463

2019

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Population Pharmacokinetics of Sulindac and Genetic Polymorphisms of FMO3 and AOX1 in Women with Preterm Labor

Pharmaceutical research, 2020-03, Vol.37 (3), p.44-44, Article 44

2020

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Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2287-2300

2012

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Identification of the Effects of Aspirin and Sulindac Sulfide on the Inhibition of HMGA2-Mediated Oncogenic Capacities in Colorectal Cancer

Molecules (Basel, Switzerland), 2020-08, Vol.25 (17), p.3826

2020

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Celecoxib and sulindac sulfide elicit anticancer effects on PIK3CA-mutated head and neck cancer cells through endoplasmic reticulum stress, reactive oxygen species, and mitochondrial dysfunction

Biochemical pharmacology, 2024-06, Vol.224, p.116221, Article 116221

2024

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Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs

British journal of cancer, 2019-03, Vol.120 (5), p.537-546

2019

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Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (27), p.8421-8426

2015

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Safety and efficacy of high-dose tamoxifen and sulindac for desmoid tumor in children: Results of a Children's Oncology Group (COG) Phase II Study

Pediatric blood & cancer, 2013-07, Vol.60 (7), p.1108-1112

2013

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The metabolism and pharmacokinetics of phospho‐sulindac (OXT‐328) and the effect of difluoromethylornithine

British journal of pharmacology, 2012-04, Vol.165 (7), p.2152-2166

2012

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Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling

Molecular cancer therapeutics, 2013-09, Vol.12 (9), p.1848-1859

2013

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Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer

Frontiers in immunology, 2023-10, Vol.14, p.1244159

2023

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Evaluation of Wnt/β-catenin signaling and its modulators in repeated dose lithium-pilocarpine rat model of status epilepticus: An acute phase study

European journal of pharmacology, 2024-03, Vol.966, p.176375-176375, Article 176375

2024

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Synthesis of Functionalized Alkylidene Indanes and Indanones through Tandem Phosphine–Palladium Catalysis

Organic letters, 2015-05, Vol.17 (9), p.2058-2061

2015

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Sulindac‐derived retinoid X receptor‐α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE−/− mice

Phospho-Sulindac (OXT-328) Inhibits Dry Eye Disease in Rabbits: A Dose-, Formulation- and Structure-Dependent Effect

Diverse amide analogs of sulindac for cancer treatment and prevention

Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity

The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase

Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis

Novel sulindac derivatives: synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activity

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

Anti-tumor activity of non-steroidal anti-inflammatory drugs: Cyclooxygenase-independent targets

An experimentally validated approach to automated biological evidence generation in drug discovery using knowledge graphs

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Population Pharmacokinetics of Sulindac and Genetic Polymorphisms of FMO3 and AOX1 in Women with Preterm Labor

Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold

Identification of the Effects of Aspirin and Sulindac Sulfide on the Inhibition of HMGA2-Mediated Oncogenic Capacities in Colorectal Cancer

Celecoxib and sulindac sulfide elicit anticancer effects on PIK3CA-mutated head and neck cancer cells through endoplasmic reticulum stress, reactive oxygen species, and mitochondrial dysfunction

Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs

Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice

Safety and efficacy of high-dose tamoxifen and sulindac for desmoid tumor in children: Results of a Children's Oncology Group (COG) Phase II Study

The metabolism and pharmacokinetics of phospho‐sulindac (OXT‐328) and the effect of difluoromethylornithine

Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling

Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer

Evaluation of Wnt/β-catenin signaling and its modulators in repeated dose lithium-pilocarpine rat model of status epilepticus: An acute phase study

Synthesis of Functionalized Alkylidene Indanes and Indanones through Tandem Phosphine–Palladium Catalysis

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