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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

Nature (London), 2019-07, Vol.571 (7764), p.284-288

2019

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Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (33), p.12163-12168

2014

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Saponins of Agave: Chemistry and bioactivity

Phytochemistry (Oxford), 2016-10, Vol.130, p.22-46

2016

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Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

Marine drugs, 2018-10, Vol.16 (11), p.410

2018

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UV–C radiation increases sterol production in the microalga Pavlova lutheri

Phytochemistry (Oxford), 2017-07, Vol.139, p.25-32

2017

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Oxysterols: A world to explore

Food and chemical toxicology, 2010-12, Vol.48 (12), p.3289-3303

2010

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Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Nature communications, 2018-12, Vol.9 (1), p.5138-13, Article 5138

2018

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Fulvestrant‑3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.8134-8140

2016

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Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection

Angewandte Chemie International Edition, 2021-12, Vol.60 (51), p.26755-26761

International ed. in English, 2021

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Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS

Phytomedicine (Stuttgart), 2020-10, Vol.77, p.153284-153284, Article 153284

2020

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Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

Nature chemical biology, 2013-09, Vol.9 (9), p.557-564

2013

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Secondary Metabolites from the Marine Sponges of the Genus Petrosia : A Literature Review of 43 Years of Research

Marine drugs, 2021-02, Vol.19 (3), p.122

2021

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Novel compounds of Djulis (Chenopodium formosanum Koidz) increases collagen, antioxidants, inhibits adipogenesis

Natural product research, 2024-08, Vol.38 (16), p.2763-2772

2024

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Cideb controls sterol‐regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites

The EMBO journal, 2019-04, Vol.38 (8), p.n/a

2019

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Sterol analogue suppresses hedgehog signalling

Nature reviews. Drug discovery, 2024-05, Vol.23 (5), p.340-340

Crunkhorn, Sarah

2024

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Cephaloliverols A and B, two sterol-hybrid meroterpenoids from Cephalotaxus oliveri

Organic & biomolecular chemistry, 2022-05, Vol.20 (18), p.3712-3716

2022

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Systematic study of 1,2,3-triazolyl sterols for the development of new drugs against parasitic Neglected Tropical Diseases

European journal of medicinal chemistry, 2023-06, Vol.254, p.115378-115378, Article 115378

2023

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Sponging off nature for new drug leads

Biochemical pharmacology, 2017-09, Vol.139, p.3-14

Andersen, Raymond J.

2017

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Pharmacological Action and Research Progress of Taraxasterol

Current pharmaceutical biotechnology, 2024-01, Vol.25 (14), p.1767-1777

2024

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Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus

PloS one, 2020-12, Vol.15 (12), p.e0240873

2020

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Sterol Derivatives Specifically Increase Anti-Inflammatory Oxylipin Formation in M2-like Macrophages by LXR-Mediated Induction of 15-LOX

Molecules (Basel, Switzerland), 2024-04, Vol.29 (8), p.1745

2024

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Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila

Autophagy, 2022-10, Vol.18 (10), p.2443-2458

2022

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Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis

Cell reports (Cambridge), 2021-11, Vol.37 (7), p.110008-110008, Article 110008

2021

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Oxysterols are allosteric activators of the oncoprotein Smoothened

Nature chemical biology, 2012-01, Vol.8 (2), p.211-220

2012

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Metabolism and Biological Activities of 4-Methyl-Sterols

Molecules (Basel, Switzerland), 2019-01, Vol.24 (3), p.451

2019

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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

Saponins of Agave: Chemistry and bioactivity

Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

UV–C radiation increases sterol production in the microalga Pavlova lutheri

Oxysterols: A world to explore

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Fulvestrant‑3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)

Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection

Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

Secondary Metabolites from the Marine Sponges of the Genus Petrosia : A Literature Review of 43 Years of Research

Novel compounds of Djulis (Chenopodium formosanum Koidz) increases collagen, antioxidants, inhibits adipogenesis

Cideb controls sterol‐regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites

Sterol analogue suppresses hedgehog signalling

Cephaloliverols A and B, two sterol-hybrid meroterpenoids from Cephalotaxus oliveri

Systematic study of 1,2,3-triazolyl sterols for the development of new drugs against parasitic Neglected Tropical Diseases

Sponging off nature for new drug leads

Pharmacological Action and Research Progress of Taraxasterol

Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus

Sterol Derivatives Specifically Increase Anti-Inflammatory Oxylipin Formation in M2-like Macrophages by LXR-Mediated Induction of 15-LOX

Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila

Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis

Oxysterols are allosteric activators of the oncoprotein Smoothened

Metabolism and Biological Activities of 4-Methyl-Sterols

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