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Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

Cell metabolism, 2015-02, Vol.21 (2), p.286-298

2015

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Azole fungicides – understanding resistance mechanisms in agricultural fungal pathogens

Pest management science, 2015-08, Vol.71 (8), p.1054-1058

2015

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Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (35), p.E3360-E3367

2013

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The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions

Antimicrobial agents and chemotherapy, 2019-05, Vol.63 (5)

2019

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A novel sterol regulatory element-binding protein gene (sreA) identified in penicillium digitatum is required for prochloraz resistance, full virulence and erg11 (cyp51) regulation

PloS one, 2015-02, Vol.10 (2), p.e0117115-e0117115

2015

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Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens

Applied microbiology and biotechnology, 2012-08, Vol.95 (4), p.825-840

2012

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Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design

Biochimica et biophysica acta. Proteins and proteomics, 2020-03, Vol.1868 (3), p.140206, Article 140206

2020

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Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

Nature (London), 2018-08, Vol.560 (7718), p.372-376

2018

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Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

Antimicrobial agents and chemotherapy, 2019-01, Vol.63 (1)

2019

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Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (44), p.E4743-E4752

2014

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Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7443-7457

2024

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In silico prediction of Antifungal compounds from Natural sources towards Lanosterol 14-alpha demethylase (CYP51) using Molecular docking and Molecular dynamic simulation

Journal of molecular graphics & modelling, 2023-06, Vol.121, p.108435-108435, Article 108435

2023

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Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control

Pest management science, 2013-02, Vol.69 (2), p.150-155

2013

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Design, Synthesis, Bioactive Evaluation, and Molecular Dynamics Simulation of Novel 4 H -Pyrano[3,2- c ]pyridine Analogues as Potential Sterol 14α-Demethylase (CYP51) Inhibitors

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.7954-7972

2024

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Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition

Journal of medicinal chemistry, 2021-12, Vol.64 (23), p.17511-17522

2021

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Rice microRNA osa-miR1848 targets the obtusifoliol 14α-demethylase gene OsCYP51G3 and mediates the biosynthesis of phytosterols and brassinosteroids during development and in response to stress

The New phytologist, 2015-11, Vol.208 (3), p.790-802

2015

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Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity

The Journal of biological chemistry, 2013-11, Vol.288 (44), p.31602-31615

2013

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Investigating role of positively selected genes and mutation sites of ERG11 in drug resistance of Candida albicans

Archives of microbiology, 2024-11, Vol.206 (11), p.437, Article 437

2024

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Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents

European journal of medicinal chemistry, 2016-11, Vol.123, p.514-522

2016

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The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii

Antimicrobial agents and chemotherapy, 2016-04, Vol.60 (4), p.2528-2531

2016

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An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy

European journal of medicinal chemistry, 2017-07, Vol.135, p.241-259

2017

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Novel mannopyranoside esters as sterol 14α-demethylase inhibitors: Synthesis, PASS predication, molecular docking, and pharmacokinetic studies

Carbohydrate research, 2020-10, Vol.496, p.108130-108130, Article 108130

2020

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Transcriptional profiling analysis of Penicillium digitatum, the causal agent of citrus green mold, unravels an inhibited ergosterol biosynthesis pathway in response to citral

BMC genomics, 2016-08, Vol.17 (1), p.599-599, Article 599

2016

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Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function

The New phytologist, 2013-05, Vol.198 (3), p.821-835

2013

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Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126951-126951, Article 126951

2020

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Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

Azole fungicides – understanding resistance mechanisms in agricultural fungal pathogens

Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions

A novel sterol regulatory element-binding protein gene (sreA) identified in penicillium digitatum is required for prochloraz resistance, full virulence and erg11 (cyp51) regulation

Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens

Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development

Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target

In silico prediction of Antifungal compounds from Natural sources towards Lanosterol 14-alpha demethylase (CYP51) using Molecular docking and Molecular dynamic simulation

Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control

Design, Synthesis, Bioactive Evaluation, and Molecular Dynamics Simulation of Novel 4 H -Pyrano[3,2- c ]pyridine Analogues as Potential Sterol 14α-Demethylase (CYP51) Inhibitors

Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition

Rice microRNA osa-miR1848 targets the obtusifoliol 14α-demethylase gene OsCYP51G3 and mediates the biosynthesis of phytosterols and brassinosteroids during development and in response to stress

Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity

Investigating role of positively selected genes and mutation sites of ERG11 in drug resistance of Candida albicans

Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents

The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii

An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy

Novel mannopyranoside esters as sterol 14α-demethylase inhibitors: Synthesis, PASS predication, molecular docking, and pharmacokinetic studies

Transcriptional profiling analysis of Penicillium digitatum, the causal agent of citrus green mold, unravels an inhibited ergosterol biosynthesis pathway in response to citral

Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function

Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus

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