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Spirocyclic Scaffolds in Medicinal Chemistry

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.150-183

2021

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The use of spirocyclic scaffolds in drug discovery

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3673-3682

2014

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Ru(II)-catalyzed vinylative dearomatization of naphthols via a C(sp2)-H bond activation approach

Journal of the American Chemical Society, 2013-11, Vol.135 (46), p.17306-17309

2013

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Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers

Angewandte Chemie International Edition, 2011-08, Vol.50 (34), p.7837-7841

International ed. in English, 2011

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Electroluminescence based on thermally activated delayed fluorescence generated by a spirobifluorene donor-acceptor structure

Chemical communications (Cambridge, England), 2012-10, Vol.48 (77), p.9580-9582

2012

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Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

Chemical reviews, 2014-08, Vol.114 (16), p.8257-8322

2014

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A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

Journal of the American Chemical Society, 2010-11, Vol.132 (43), p.15328-15333

2010

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Palladium-Catalyzed [3 + 2] Cycloaddition via Twofold 1,3-C(sp3)–H Activation

Journal of the American Chemical Society, 2020-09, Vol.142 (39), p.16552-16556

2020

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Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

Accounts of chemical research, 2014-04, Vol.47 (4), p.1296-1310

2014

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Hydroarylation of Arenes via Reductive Radical-Polar Crossover

Journal of the American Chemical Society, 2020-05, Vol.142 (20), p.9163-9168

2020

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Kinetic Resolution of Aziridines Enabled by N‐Heterocyclic Carbene/Copper Cooperative Catalysis: Carbene Dose‐Controlled Chemo‐Switchability

Angewandte Chemie International Edition, 2021-02, Vol.60 (6), p.3268-3276

International ed. in English, 2021

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Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations

Journal of the American Chemical Society, 2015-07, Vol.137 (28), p.8928-8931

2015

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Total syntheses of natural products containing spirocarbocycles

Organic & biomolecular chemistry, 2015-01, Vol.13 (39), p.997-9933

2015

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An overview of spirooxindole as a promising scaffold for novel drug discovery

Expert opinion on drug discovery, 2020-05, Vol.15 (5), p.603-625

2020

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Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

Chemical Society reviews, 2012-01, Vol.41 (21), p.7247-729

2012

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New and unusual scaffolds in medicinal chemistry

Chemical Society reviews, 2011-11, Vol.40 (11), p.5514

Marson, Charles M

2011

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The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2'-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction

Chemical communications (Cambridge, England), 2015-05, Vol.51 (42), p.8789-8792

2015

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Spirooxindoles: Promising scaffolds for anticancer agents

European journal of medicinal chemistry, 2015-06, Vol.97, p.673-698

2015

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A Visible-Light-Mediated Radical Smiles Rearrangement and its Application to the Synthesis of a Difluoro-Substituted Spirocyclic ORL-1 Antagonist

Angewandte Chemie International Edition, 2015-12, Vol.54 (49), p.14898-14902

International ed. in English, 2015

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Spirocyclic Motifs in Natural Products

Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4165

2019

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Synthesis of Spirocyclic Indolenines

Chemistry : a European journal, 2016-02, Vol.22 (9), p.2856-2881

2016

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Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N‑Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones

Journal of organic chemistry, 2017-04, Vol.82 (7), p.3359-3367

2017

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Asymmetric Dearomatizing Spirolactonization of Naphthols Catalyzed by Spirobiindane-Based Chiral Hypervalent Iodine Species

Journal of the American Chemical Society, 2013-03, Vol.135 (11), p.4558-4566

2013

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Palladium(0)-Catalyzed Arylative Dearomatization of Phenols

Journal of the American Chemical Society, 2011-06, Vol.133 (24), p.9282-9285

2011

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Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

Journal of the American Chemical Society, 2011-04, Vol.133 (13), p.4672-4675

2011

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Spirocyclic Scaffolds in Medicinal Chemistry

The use of spirocyclic scaffolds in drug discovery

Ru(II)-catalyzed vinylative dearomatization of naphthols via a C(sp2)-H bond activation approach

Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers

Electroluminescence based on thermally activated delayed fluorescence generated by a spirobifluorene donor-acceptor structure

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

Palladium-Catalyzed [3 + 2] Cycloaddition via Twofold 1,3-C(sp3)–H Activation

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

Hydroarylation of Arenes via Reductive Radical-Polar Crossover

Kinetic Resolution of Aziridines Enabled by N‐Heterocyclic Carbene/Copper Cooperative Catalysis: Carbene Dose‐Controlled Chemo‐Switchability

Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations

Total syntheses of natural products containing spirocarbocycles

An overview of spirooxindole as a promising scaffold for novel drug discovery

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

New and unusual scaffolds in medicinal chemistry

The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2'-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction

Spirooxindoles: Promising scaffolds for anticancer agents

A Visible-Light-Mediated Radical Smiles Rearrangement and its Application to the Synthesis of a Difluoro-Substituted Spirocyclic ORL-1 Antagonist

Spirocyclic Motifs in Natural Products

Synthesis of Spirocyclic Indolenines

Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N‑Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones

Asymmetric Dearomatizing Spirolactonization of Naphthols Catalyzed by Spirobiindane-Based Chiral Hypervalent Iodine Species

Palladium(0)-Catalyzed Arylative Dearomatization of Phenols

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

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