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Mir-21 Promotes Cardiac Fibrosis After Myocardial Infarction Via Targeting Smad7

Cellular physiology and biochemistry, 2017-01, Vol.42 (6), p.2207-2219

2017

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Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure

The Journal of clinical investigation, 2022-02, Vol.132 (3), p.1-19

2022

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BMP-7 inhibits renal fibrosis in diabetic nephropathy via miR-21 downregulation

Life sciences (1973), 2019-12, Vol.238, p.116957-116957, Article 116957

2019

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Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

Nature communications, 2017-12, Vol.8 (1), p.2116-16, Article 2116

2017

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MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway

Scientific reports, 2017-02, Vol.7 (1), p.43427-43427, Article 43427

2017

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LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells

Nucleic acids research, 2022-10, Vol.50 (18), p.10526

2022

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The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

Oncogene, 2012-12, Vol.31 (50), p.5162-5171

2012

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YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts

Cell communication and signaling, 2018-04, Vol.16 (1), p.18-18, Article 18

2018

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Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling

Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (38), p.10113-10118

2017

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Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-β signaling

Oncogene, 2022-04, Vol.41 (18), p.2597-2608

2022

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Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling

The Journal of biological chemistry, 2016-01, Vol.291 (1), p.382-392

2016

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Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis

American journal of physiology: Gastrointestinal and liver physiology, 2015-02, Vol.308 (4), p.G298-G312

2015

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CDCA7 promotes TGF‐β‐induced epithelial–mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC

Cancer science, 2023-01, Vol.114 (1), p.91-104

2023

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SMAD signaling promotes melanoma metastasis independently of phenotype switching

The Journal of clinical investigation, 2019-07, Vol.129 (7), p.2702-2716

2019

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Hsa-miR-186-5p regulates TGFβ signaling pathway through expression suppression of SMAD6 and SMAD7 genes in colorectal cancer

Biological chemistry, 2021-03, Vol.402 (4), p.469

2021

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Long noncoding RNA NEAT1 promotes cardiac fibrosis in heart failure through increased recruitment of EZH2 to the Smad7 promoter region

Journal of translational medicine, 2022-01, Vol.20 (1), p.7-7, Article 7

2022

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Exosomal miR‐21‐5p derived from multiple myeloma cells promote renal epithelial–mesenchymal transition through targeting TGF‐β/SMAD7 signalling pathway

Clinical and experimental pharmacology & physiology, 2023-09, Vol.50 (9), p.711-718

2023

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Expression and function of Smad7 in autoimmune and inflammatory diseases

Journal of molecular medicine (Berlin, Germany), 2021-09, Vol.99 (9), p.1209-1220

2021

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MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST

Cell death & disease, 2016-04, Vol.7 (4), p.e2203-e2203

2016

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Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR‐21‐3p/SMAD7 axis

Cancer science, 2024-03, Vol.115 (3), p.974-988

2024

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MicroRNA-30e-3p reduces coronary microembolism-induced cardiomyocyte pyroptosis and inflammation by sequestering HDAC2 from the SMAD7 promoter

American Journal of Physiology: Cell Physiology, 2023-02, Vol.324 (2), p.C222-C235

2023

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Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension

PloS one, 2013-07, Vol.8 (7), p.e70195

2013

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SETDB1 regulates SMAD7 expression for breast cancer metastasis

BMB Reports, 2019, 52(2), , pp.139-144

2019

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miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction

Mechanisms of ageing and development, 2023-06, Vol.212, p.111818-111818, Article 111818

2023

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Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

The New England journal of medicine, 2015-03, Vol.372 (12), p.1104-1113

2015

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Mir-21 Promotes Cardiac Fibrosis After Myocardial Infarction Via Targeting Smad7

Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure

BMP-7 inhibits renal fibrosis in diabetic nephropathy via miR-21 downregulation

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway

LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells

The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts

Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling

Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-β signaling

Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling

Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis

CDCA7 promotes TGF‐β‐induced epithelial–mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC

SMAD signaling promotes melanoma metastasis independently of phenotype switching

Hsa-miR-186-5p regulates TGFβ signaling pathway through expression suppression of SMAD6 and SMAD7 genes in colorectal cancer

Long noncoding RNA NEAT1 promotes cardiac fibrosis in heart failure through increased recruitment of EZH2 to the Smad7 promoter region

Exosomal miR‐21‐5p derived from multiple myeloma cells promote renal epithelial–mesenchymal transition through targeting TGF‐β/SMAD7 signalling pathway

Expression and function of Smad7 in autoimmune and inflammatory diseases

MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST

Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR‐21‐3p/SMAD7 axis

MicroRNA-30e-3p reduces coronary microembolism-induced cardiomyocyte pyroptosis and inflammation by sequestering HDAC2 from the SMAD7 promoter

Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension

SETDB1 regulates SMAD7 expression for breast cancer metastasis

miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

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