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Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists

Bioorganic & medicinal chemistry, 2014-11, Vol.22 (21), p.6026-6038

2014

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4-Phenyl quinoline derivatives as potential serotonin receptor ligands with antiproliferative activity

European journal of medicinal chemistry, 2017-08, Vol.136, p.246-258

2017

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Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (4), p.606-611

2018

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Serotonin 5‑HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7160-7181

2014

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Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer’s disease

European journal of medicinal chemistry, 2016-10, Vol.121, p.283-293

2016

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New Entry to Polycyclic Fused Indoles via Gold(I)-catalyzed Cascade Reaction

Chemistry, an Asian journal, 2013-08, Vol.8 (8), p.1776-1779

2013

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New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263

European journal of medicinal chemistry, 2021-03, Vol.214, p.113243-113243, Article 113243

2021

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Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis

Acta pharmacologica Sinica, 2019-09, Vol.40 (9), p.1138-1156

2019

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A new serotonin 5-HT 6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding

Scientific reports, 2017-01, Vol.7, p.41293

2017

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Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

BMC cancer, 2020-08, Vol.20 (1), p.724-17, Article 724

2020

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Design, Synthesis and Biological Investigation of Flavone Derivatives as Potential Multi-Receptor Atypical Antipsychotics

Molecules (Basel, Switzerland), 2020-09, Vol.25 (18), p.4107

2020

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Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT7 Receptor Agonists and Antagonists

Journal of medicinal chemistry, 2004-07, Vol.47 (16), p.3927-3930

2004

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5-HT 6 receptor antagonists. Design, synthesis, and structure-activity relationship of substituted 2-(1-methyl-4-piperazinyl)pyridines

Bioorganic & medicinal chemistry letters, 2023-11, Vol.96, p.129497

2023

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Novel Arylsulfonamide Derivatives with 5‑HT6/5-HT7 Receptor Antagonism Targeting Behavioral and Psychological Symptoms of Dementia

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4543-4557

2014

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Binding modes of chain arylpiperazines to 5-HT1a, 5-HT2a and 5-HT7 receptors

Mini reviews in medicinal chemistry, 2013-08, Vol.13 (10), p.1516-1539

2013

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A Mild Procedure for the Lewis Acid-Catalyzed Ring-Opening of Activated Cyclopropanes with Amine Nucleophiles

Organic letters, 2008-07, Vol.10 (13), p.2809-2812

2008

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Pharmacology and Therapeutic Potential of the 5-HT 7 Receptor

ACS chemical neuroscience, 2019-01, Vol.10 (1), p.89-119

2019

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Investigation of Potential Antioxidant, Thrombolytic and Neuropharmacological Activities of Homalomena aromatica Leaves Using Experimental and In Silico Approaches

Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.975

2021

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Enantioselective Synthesis of Tetrahydrocarbazoles through a Michael Addition/Ciamician-Plancher Rearrangement Sequence: Asymmetric Synthesis of a Potent Constrained Analogue of MS-245

Chemistry : a European journal, 2012-10, Vol.18 (42), p.13250-13254

2012

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The 5-HT3 receptor as a therapeutic target

Expert opinion on therapeutic targets, 2007-04, Vol.11 (4), p.527-540

2007

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Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors

Journal of medicinal chemistry, 2012-06, Vol.55 (12), p.5749-5759

2012

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Predicting biological activity and design of 5-HT 6 antagonists through assessment of ANN-QSAR models in the context of Alzheimer's disease

Journal of molecular modeling, 2024-09, Vol.30 (10), p.350

2024

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Novel 1H‑Pyrrolo[3,2‑c]quinoline Based 5‑HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer’s Disease

ACS chemical neuroscience, 2016-07, Vol.7 (7), p.972-983

2016

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Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders

Pharmacology & therapeutics (Oxford), 2008-02, Vol.117 (2), p.207-231

2008

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Sustained release of risperidone from biodegradable microspheres prepared by in-situ suspension-evaporation process

International journal of pharmaceutics, 2016-04, Vol.503 (1-2), p.8-15

2016

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Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists

4-Phenyl quinoline derivatives as potential serotonin receptor ligands with antiproliferative activity

Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs

Serotonin 5‑HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer’s disease

New Entry to Polycyclic Fused Indoles via Gold(I)-catalyzed Cascade Reaction

New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263

Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis

A new serotonin 5-HT 6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

Design, Synthesis and Biological Investigation of Flavone Derivatives as Potential Multi-Receptor Atypical Antipsychotics

Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT7 Receptor Agonists and Antagonists

5-HT 6 receptor antagonists. Design, synthesis, and structure-activity relationship of substituted 2-(1-methyl-4-piperazinyl)pyridines

Novel Arylsulfonamide Derivatives with 5‑HT6/5-HT7 Receptor Antagonism Targeting Behavioral and Psychological Symptoms of Dementia

Binding modes of chain arylpiperazines to 5-HT1a, 5-HT2a and 5-HT7 receptors

A Mild Procedure for the Lewis Acid-Catalyzed Ring-Opening of Activated Cyclopropanes with Amine Nucleophiles

Pharmacology and Therapeutic Potential of the 5-HT 7 Receptor

Investigation of Potential Antioxidant, Thrombolytic and Neuropharmacological Activities of Homalomena aromatica Leaves Using Experimental and In Silico Approaches

Enantioselective Synthesis of Tetrahydrocarbazoles through a Michael Addition/Ciamician-Plancher Rearrangement Sequence: Asymmetric Synthesis of a Potent Constrained Analogue of MS-245

The 5-HT3 receptor as a therapeutic target

Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors

Predicting biological activity and design of 5-HT 6 antagonists through assessment of ANN-QSAR models in the context of Alzheimer's disease

Novel 1H‑Pyrrolo[3,2‑c]quinoline Based 5‑HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer’s Disease

Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders

Sustained release of risperidone from biodegradable microspheres prepared by in-situ suspension-evaporation process

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