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HIV‐protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO‐hybridized derivatives?

International journal of cancer, 2017-04, Vol.140 (8), p.1713-1726

2017

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Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: Preparation, characterization, and in vivo evaluation

International journal of pharmaceutics, 2014-11, Vol.475 (1-2), p.191-197

2014

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Development and characterization of folate anchored Saquinavir entrapped PLGA nanoparticles for anti-tumor activity

Drug development and industrial pharmacy, 2015-11, Vol.41 (11), p.1888-1901

2015

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Drug Resistance Mechanism of M46I-Mutation-Induced Saquinavir Resistance in HIV-1 Protease Using Molecular Dynamics Simulation and Binding Energy Calculation

Viruses, 2022-03, Vol.14 (4), p.697

2022

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Nanosized Cubosomal Thermogelling Dispersion Loaded with Saquinavir Mesylate to Improve Its Bioavailability: Preparation, Optimization, in vitro and in vivo Evaluation

International journal of nanomedicine, 2020-01, Vol.15, p.5113-5129

Hosny, Khaled M

2020

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Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier

Journal of controlled release, 2013-03, Vol.166 (2), p.115-123

2013

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Targeting SVCT for enhanced drug absorption: Synthesis and in vitro evaluation of a novel vitamin C conjugated prodrug of saquinavir

International journal of pharmaceutics, 2011-07, Vol.414 (1), p.77-85

2011

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Development Of Saquinavir Mesylate Nanoemulsion-Loaded Transdermal Films: Two-Step Optimization Of Permeation Parameters, Characterization, And Ex Vivo And In Vivo Evaluation

International journal of nanomedicine, 2019-11, Vol.14, p.8589-8601

Hosny, Khaled M

2019

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Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting

Drug delivery, 2014-03, Vol.21 (2), p.148-154

Mahajan, Hitendra S.

2014

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Dextran–protamine coated nanostructured lipid carriers as mucus-penetrating nanoparticles for lipophilic drugs

International journal of pharmaceutics, 2014-07, Vol.468 (1-2), p.105-111

2014

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Enhancement of cellular uptake, transport and oral absorption of protease inhibitor saquinavir by nanocrystal formulation

Acta pharmacologica Sinica, 2015-09, Vol.36 (9), p.1151-1160

2015

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The inhibition effect of garlic‐derived compounds on human immunodeficiency virus type 1 and saquinavir

Journal of biochemical and molecular toxicology, 2018-11, Vol.32 (11), p.e22215-N/A

GÖKALP, Faik

2018

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Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by Mycobacterium tuberculosis and Helps Control the Phagosomal Replicative Niches

International journal of molecular sciences, 2023-01, Vol.24 (2), p.1142

2023

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A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease

Travel medicine and infectious disease, 2020-05, Vol.35, p.101646-101646, Article 101646

2020

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Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir

European journal of medicinal chemistry, 2015-03, Vol.93, p.338-348

2015

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Targeting delivery of saquinavir to the brain using 83-14 monoclonal antibody-grafted solid lipid nanoparticles

Biomaterials, 2013-07, Vol.34 (20), p.4818-4830

2013

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Current evidence for the risk of PR prolongation, QRS widening, QT prolongation, from lopinavir, ritonavir, atazanavir, and saquinavir: A systematic review

Medicine (Baltimore), 2021-08, Vol.100 (31), p.e26787

2021

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Revealing the drug resistance mechanism of saquinavir due to G48V and V82F mutations in subtype CRF01_AE HIV-1 protease: molecular dynamics simulation and binding free energy calculations

Journal of biomolecular structure & dynamics, 2023-02, Vol.41 (3), p.1000-1017

2023

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Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations

International journal of pharmaceutics, 2008-01, Vol.347 (1), p.93-101

2008

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Topical Protease Inhibitor Increases Tumor-Free and Overall Survival in CD4-Depleted Mouse Model of Anal Cancer

Viruses, 2024-09, Vol.16 (9), p.1421

2024

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Drug binding dynamics of the dimeric SARS-CoV-2 main protease, determined by molecular dynamics simulation

Scientific reports, 2020-10, Vol.10 (1), p.16986-16986, Article 16986

2020

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Microenvironmental pH modifying films for buccal delivery of saquinavir: Effects of organic acids on pH and drug release in vitro

International journal of pharmaceutics, 2020-07, Vol.585, p.119567, Article 119567

2020

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Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats

International journal of pharmaceutics, 2007-05, Vol.336 (2), p.233-240

2007

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The antitumor properties of a nontoxic, nitric oxide–modified version of saquinavir are independent of Akt

Molecular cancer therapeutics, 2009-05, Vol.8 (5), p.1169-1178

2009

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The use of a topical protease inhibitor, Saquinavir, to alleviate mouse papillomavirus-mediated anal disease

Virology (New York, N.Y.), 2022-11, Vol.576, p.96-104

2022

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HIV‐protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO‐hybridized derivatives?

Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: Preparation, characterization, and in vivo evaluation

Development and characterization of folate anchored Saquinavir entrapped PLGA nanoparticles for anti-tumor activity

Drug Resistance Mechanism of M46I-Mutation-Induced Saquinavir Resistance in HIV-1 Protease Using Molecular Dynamics Simulation and Binding Energy Calculation

Nanosized Cubosomal Thermogelling Dispersion Loaded with Saquinavir Mesylate to Improve Its Bioavailability: Preparation, Optimization, in vitro and in vivo Evaluation

Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier

Targeting SVCT for enhanced drug absorption: Synthesis and in vitro evaluation of a novel vitamin C conjugated prodrug of saquinavir

Development Of Saquinavir Mesylate Nanoemulsion-Loaded Transdermal Films: Two-Step Optimization Of Permeation Parameters, Characterization, And Ex Vivo And In Vivo Evaluation

Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting

Dextran–protamine coated nanostructured lipid carriers as mucus-penetrating nanoparticles for lipophilic drugs

Enhancement of cellular uptake, transport and oral absorption of protease inhibitor saquinavir by nanocrystal formulation

The inhibition effect of garlic‐derived compounds on human immunodeficiency virus type 1 and saquinavir

Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by Mycobacterium tuberculosis and Helps Control the Phagosomal Replicative Niches

A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease

Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir

Targeting delivery of saquinavir to the brain using 83-14 monoclonal antibody-grafted solid lipid nanoparticles

Current evidence for the risk of PR prolongation, QRS widening, QT prolongation, from lopinavir, ritonavir, atazanavir, and saquinavir: A systematic review

Revealing the drug resistance mechanism of saquinavir due to G48V and V82F mutations in subtype CRF01_AE HIV-1 protease: molecular dynamics simulation and binding free energy calculations

Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations

Topical Protease Inhibitor Increases Tumor-Free and Overall Survival in CD4-Depleted Mouse Model of Anal Cancer

Drug binding dynamics of the dimeric SARS-CoV-2 main protease, determined by molecular dynamics simulation

Microenvironmental pH modifying films for buccal delivery of saquinavir: Effects of organic acids on pH and drug release in vitro

Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats

The antitumor properties of a nontoxic, nitric oxide–modified version of saquinavir are independent of Akt

The use of a topical protease inhibitor, Saquinavir, to alleviate mouse papillomavirus-mediated anal disease

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