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SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer

Cancer letters, 2020-01, Vol.469, p.89-101

2020

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Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5

Synapse (New York, N.Y.), 2012-01, Vol.66 (1), p.61-70

2012

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Temporal Effect of Adrenocorticotrophic Hormone on Adrenal Glucocorticoid Steroidogenesis: Involvement of the Transducer of Regulated Cyclic AMP-Response Element-Binding Protein Activity

Journal of neuroendocrinology, 2011-02, Vol.23 (2), p.136-142

2011

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ETNPPL modulates hyperinsulinemia‐induced insulin resistance through the SIK1/ROS‐mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes

Journal of cellular physiology, 2023-05, Vol.238 (5), p.1046-1062

2023

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The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

Cancers, 2021-07, Vol.13 (15), p.3658

2021

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The role of salt-inducible kinases on the modulation of renal and intestinal Na+,K+-ATPase activity during short- and long-term high-salt intake

European journal of pharmacology, 2021-08, Vol.904, p.174153-174153, Article 174153

2021

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Salt‐Inducible Kinase 2‐Triggered Release of Its Inhibitor from Hydrogel to Suppress Ovarian Cancer Metastasis

Advanced science, 2022-08, Vol.9 (22), p.e2202260-n/a

2022

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New long noncoding RNA biomarkers and ceRNA networks on miR-616-3p in colorectal cancer: Bioinformatics-based study

Journal of research in medical sciences, 2024, Vol.29 (1), p.10-10

2024

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Salt-inducible kinase 2 (SIK2) inhibitor ARN-3236 attenuates bleomycin-induced pulmonary fibrosis in mice

BMC pulmonary medicine, 2022-04, Vol.22 (1), p.140-140, Article 140

2022

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The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway

Genetics (Austin), 2019-12, Vol.213 (4), p.1465-1478

2019

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Blocking salt‐inducible kinases with YKL‐06‐061 prevents PTZ‐induced seizures in mice

Brain and behavior, 2023-12, Vol.13 (12), p.e3305-n/a

2023

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Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake

Clinical and experimental hypertension (1993), 2021-07, Vol.43 (5), p.428-435

2021

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Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells

Molecular medicine reports, 2021-11, Vol.24 (5), Article 822

2021

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Silencing the constitutive active transcription factor CREB by the LKB1‐SIK signaling cascade

The FEBS journal, 2006-06, Vol.273 (12), p.2730-2748

2006

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Downregulation of SIK2 expression promotes the melanogenic program in mice

Pigment cell and melanoma research, 2010-12, Vol.23 (6), p.809-819

2010

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Salt‐inducible kinase 3 deficiency exacerbates lipopolysaccharide‐induced endotoxin shock accompanied by increased levels of pro‐inflammatory molecules in mice

Immunology, 2015-06, Vol.145 (2), p.268-278

2015

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The target landscape of clinical kinase drugs

Science (American Association for the Advancement of Science), 2017-12, Vol.358 (6367), p.1148-1148

2017

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Modulation of Aanat gene transcription in the rat pineal gland

Journal of neurochemistry, 2010-01, Vol.112 (2), p.321-331

2010

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BS28 Salt-inducible kinase 2 (SIK2) as a new putative therapeutic target for heart failure

Heart (British Cardiac Society), 2022-06, Vol.108 (Suppl 1), p.A162-A162

2022

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The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity

The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107201-107201, Article 107201

2024

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LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia

Molecular cell, 2018-03, Vol.69 (6), p.1017-1027.e6

2018

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M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3

Journal of nanobiotechnology, 2020-04, Vol.18 (1), p.66-66

2020

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Discovery of novel and selective SIK2 inhibitors by the application of AlphaFold structures and generative models

Bioorganic & medicinal chemistry, 2023-08, Vol.91, p.117414-117414, Article 117414

2023

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Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice

Proceedings of the National Academy of Sciences - PNAS, 2022-12, Vol.119 (50), p.e2214396119

2022

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IGF2BP1 enhances the stability of SIK2 mRNA through m6A modification to promote non-small cell lung cancer progression

Biochemical and biophysical research communications, 2023-12, Vol.684, p.149113-149113, Article 149113

2023

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SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer

Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5

Temporal Effect of Adrenocorticotrophic Hormone on Adrenal Glucocorticoid Steroidogenesis: Involvement of the Transducer of Regulated Cyclic AMP-Response Element-Binding Protein Activity

ETNPPL modulates hyperinsulinemia‐induced insulin resistance through the SIK1/ROS‐mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes

The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

The role of salt-inducible kinases on the modulation of renal and intestinal Na+,K+-ATPase activity during short- and long-term high-salt intake

Salt‐Inducible Kinase 2‐Triggered Release of Its Inhibitor from Hydrogel to Suppress Ovarian Cancer Metastasis

New long noncoding RNA biomarkers and ceRNA networks on miR-616-3p in colorectal cancer: Bioinformatics-based study

Salt-inducible kinase 2 (SIK2) inhibitor ARN-3236 attenuates bleomycin-induced pulmonary fibrosis in mice

The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway

Blocking salt‐inducible kinases with YKL‐06‐061 prevents PTZ‐induced seizures in mice

Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake

Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells

Silencing the constitutive active transcription factor CREB by the LKB1‐SIK signaling cascade

Downregulation of SIK2 expression promotes the melanogenic program in mice

Salt‐inducible kinase 3 deficiency exacerbates lipopolysaccharide‐induced endotoxin shock accompanied by increased levels of pro‐inflammatory molecules in mice

The target landscape of clinical kinase drugs

Modulation of Aanat gene transcription in the rat pineal gland

BS28 Salt-inducible kinase 2 (SIK2) as a new putative therapeutic target for heart failure

The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity

LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia

M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3

Discovery of novel and selective SIK2 inhibitors by the application of AlphaFold structures and generative models

Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice

IGF2BP1 enhances the stability of SIK2 mRNA through m6A modification to promote non-small cell lung cancer progression

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