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FEMA GRAS assessment of natural flavor complexes: Clove, cinnamon leaf and West Indian bay leaf-derived flavoring ingredients

Food and chemical toxicology, 2020-11, Vol.145, p.111585, Article 111585

2020

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In vitro and in silico study on consequences of combined exposure to the food-borne alkenylbenzenes estragole and safrole

Toxicology in vitro, 2022-03, Vol.79, p.105290-105290, Article 105290

2022

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Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole

Xenobiotica, 2018-11, Vol.48 (11), p.1164-1172

2018

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Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation

Xenobiotica, 2019-12, Vol.49 (12), p.1504-1515

2019

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Betel quid containing safrole enhances metabolic activation of tobacco specific 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Environmental pollution (1987), 2019-08, Vol.251, p.13-21

2019

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Safrole induced cytotoxicity, DNA damage, and apoptosis in macrophages via reactive oxygen species generation and Akt phosphorylation

Environmental toxicology and pharmacology, 2018-12, Vol.64, p.94-100

2018

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Synthesis and antiviral activity of a novel glycosyl sulfoxide against classical swine fever virus

Bioorganic & medicinal chemistry, 2014-05, Vol.22 (9), p.2662-2670

2014

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Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats

Toxicology (Amsterdam), 2011-12, Vol.290 (2), p.312-321

2011

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In vivo formation of N7-guanine DNA adduct by safrole 2′,3′-oxide in mice

Toxicology letters, 2012-09, Vol.213 (3), p.309-315

2012

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In vivo genotoxicity of estragole in male F344 rats

Environmental and molecular mutagenesis, 2015-05, Vol.56 (4), p.356-365

2015

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Safrole-2′,3′-oxide induces cytotoxic and genotoxic effects in HepG2 cells and in mice

Mutation research, 2011-12, Vol.726 (2), p.234-241

2011

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Toxicological Actions of Plant-Derived and Anthropogenic Methylenedioxyphenyl-Substituted Chemicals in Mammals and Insects

Journal of toxicology and environmental health. Part B, Critical reviews, 2012-08, Vol.15 (6), p.365-395

Murray, Michael

2012

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Safrole-2′,3′-oxide induces atherosclerotic plaque vulnerability in apolipoprotein E-knockout mice

Toxicology letters, 2013-02, Vol.217 (2), p.129-136

2013

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SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens

Food and chemical toxicology, 2008-04, Vol.46 (4), p.1249-1256

2008

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Safrole-modulated immune response is mediated through enhancing the CD11b surface marker and stimulating the phagocytosis by macrophages in BALB/c mice

Human & experimental toxicology, 2012-09, Vol.31 (9), p.898-904

2012

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Safrole-DNA adducts in tissues from esophageal cancer patients: clues to areca-related esophageal carcinogenesis

Mutation research, 2005-01, Vol.565 (2), p.121

2005

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Reduction of safrole and methyleugenol in Asari radix et rhizoma by decoction

Forschende Komplementarmedizin (2006), 2009-06, Vol.16 (3), p.162-166

2009

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Genotoxic effects of eugenol, isoeugenol and safrole in the wing spot test of Drosophila melanogaster

Mutation research, 2005-04, Vol.582 (1), p.87-94

2005

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Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole

Carcinogenesis (New York), 1994-02, Vol.15 (2), p.215-218

1994

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Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole

Food and chemical toxicology, 2005-05, Vol.43 (5), p.707-712

2005

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Safrole-induced cellular Ca2+ increases and death in human osteosarcoma cells

Pharmacological research, 2006-08, Vol.54 (2), p.103-110

2006

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Safrole-Induced Ca2+ Mobilization and Cytotoxicity in Human PC3 Prostate Cancer Cells

Journal of receptors and signal transduction, 2006, Vol.26 (3), p.199-212

2006

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In vivo genotoxicity and DNA adduct levels in the liver of rats treated with safrole

Carcinogenesis (New York), 1998, Vol.19 (1), p.141-146

1998

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Testicular Toxicity of Molinate in the Rat: Metabolic Activation via Sulfoxidation

Toxicology and applied pharmacology, 1998-04, Vol.149 (2), p.159-166

1998

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Elevated expression of NF-kappaB in oral submucous fibrosis--evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts

Oral oncology, 2007-07, Vol.43 (6), p.557

2007

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FEMA GRAS assessment of natural flavor complexes: Clove, cinnamon leaf and West Indian bay leaf-derived flavoring ingredients

In vitro and in silico study on consequences of combined exposure to the food-borne alkenylbenzenes estragole and safrole

Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole

Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation

Betel quid containing safrole enhances metabolic activation of tobacco specific 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Safrole induced cytotoxicity, DNA damage, and apoptosis in macrophages via reactive oxygen species generation and Akt phosphorylation

Synthesis and antiviral activity of a novel glycosyl sulfoxide against classical swine fever virus

Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats

In vivo formation of N7-guanine DNA adduct by safrole 2′,3′-oxide in mice

In vivo genotoxicity of estragole in male F344 rats

Safrole-2′,3′-oxide induces cytotoxic and genotoxic effects in HepG2 cells and in mice

Toxicological Actions of Plant-Derived and Anthropogenic Methylenedioxyphenyl-Substituted Chemicals in Mammals and Insects

Safrole-2′,3′-oxide induces atherosclerotic plaque vulnerability in apolipoprotein E-knockout mice

SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens

Safrole-modulated immune response is mediated through enhancing the CD11b surface marker and stimulating the phagocytosis by macrophages in BALB/c mice

Safrole-DNA adducts in tissues from esophageal cancer patients: clues to areca-related esophageal carcinogenesis

Reduction of safrole and methyleugenol in Asari radix et rhizoma by decoction

Genotoxic effects of eugenol, isoeugenol and safrole in the wing spot test of Drosophila melanogaster

Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole

Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole

Safrole-induced cellular Ca2+ increases and death in human osteosarcoma cells

Safrole-Induced Ca2+ Mobilization and Cytotoxicity in Human PC3 Prostate Cancer Cells

In vivo genotoxicity and DNA adduct levels in the liver of rats treated with safrole

Testicular Toxicity of Molinate in the Rat: Metabolic Activation via Sulfoxidation

Elevated expression of NF-kappaB in oral submucous fibrosis--evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts

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