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Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation

RNA (Cambridge), 2009-01, Vol.15 (1), p.153-175

2009

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Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8

Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6141), p.80-84

2013

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Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts

Cell reports (Cambridge), 2020-06, Vol.31 (9), p.107716-107716, Article 107716

2020

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Splicing regulator SLU7 is essential for maintaining liver homeostasis

The Journal of clinical investigation, 2014-07, Vol.124 (7), p.2909-2920

2014

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Discovery of spiro[indole-3,2′-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP

Bioorganic & medicinal chemistry, 2017-09, Vol.25 (17), p.4753-4767

2017

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Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

Clinical and translational science, 2021-07, Vol.14 (4), p.1490-1504

2021

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Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos

Developmental biology, 2012-05, Vol.365 (2), p.445-457

2012

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The U11-48K Protein Contacts the 5′ Splice Site of U12-Type Introns and the U11-59K Protein

Molecular and Cellular Biology, 2008-05, Vol.28 (10), p.3548-3560

2008

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snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN

Journal of cell science, 2001-12, Vol.114 (Pt 24), p.4407-4419

2001

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PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

Genes & development, 2008-05, Vol.22 (10), p.1356-1368

2008

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Positive regulation of ASK1-mediated c-Jun NH -terminal kinase signaling pathway by the WD-repeat protein Gemin5

Cell death and differentiation, 2007-08, Vol.14 (8), p.1518-1528

2007

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Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma

Cell reports (Cambridge), 2016-01, Vol.14 (3), p.598-610

2016

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U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

Nature (London), 2010-12, Vol.468 (7324), p.664-668

2010

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BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing

Molecular cell, 2014-10, Vol.56 (2), p.298-310

2014

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SF3B1 mutations constitute a novel therapeutic target in breast cancer

The Journal of pathology, 2015-03, Vol.235 (4), p.571-580

2015

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Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

Nature chemical biology, 2007-09, Vol.3 (9), p.576-583

2007

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Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

ACS chemical biology, 2011-03, Vol.6 (3), p.229-233

2011

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Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation

Cell chemical biology, 2021-09, Vol.28 (9), p.1356-1365.e4

2021

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The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1

Leukemia, 2016-02, Vol.30 (2), p.351-360

2016

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Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs

The Journal of biological chemistry, 2014-01, Vol.289 (4), p.1938-1947

2014

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Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

RNA (Cambridge), 2016-03, Vol.22 (3), p.350-359

2016

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U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish

Nucleic acids research, 2015-03, Vol.43 (6), p.3208-3218

2015

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An RNA map predicting Nova-dependent splicing regulation

Nature, 2006-11, Vol.444 (7119), p.580-586

2006

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Integrated Bioinformatics Analysis Reveals Marker Genes and Potential Therapeutic Targets for Pulmonary Arterial Hypertension

Genes, 2021-08, Vol.12 (9), p.1339

2021

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Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches

The Journal of biological chemistry, 2013-10, Vol.288 (42), p.30125-30138

2013

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Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation

Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8

Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts

Splicing regulator SLU7 is essential for maintaining liver homeostasis

Discovery of spiro[indole-3,2′-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP

Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos

The U11-48K Protein Contacts the 5′ Splice Site of U12-Type Introns and the U11-59K Protein

snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN

PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

Positive regulation of ASK1-mediated c-Jun NH -terminal kinase signaling pathway by the WD-repeat protein Gemin5

Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma

U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing

SF3B1 mutations constitute a novel therapeutic target in breast cancer

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1

Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish

An RNA map predicting Nova-dependent splicing regulation

Integrated Bioinformatics Analysis Reveals Marker Genes and Potential Therapeutic Targets for Pulmonary Arterial Hypertension

Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches

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