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The Molecular Function of σ Receptors: Past, Present, and Future

Trends in pharmacological sciences (Regular ed.), 2019-09, Vol.40 (9), p.636-654

2019

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Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity

Molecules (Basel, Switzerland), 2017-08, Vol.22 (9), p.1408

2017

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The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

Trends in pharmacological sciences (Regular ed.), 2016-04, Vol.37 (4), p.262-278

2016

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The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo

Experimental neurology, 2014-11, Vol.261, p.501-509

2014

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Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use

Pharmacology & therapeutics (Oxford), 2016-08, Vol.164, p.170-182

2016

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Small Molecules Selectively Targeting Sigma‑1 Receptor for the Treatment of Neurological Diseases

Journal of medicinal chemistry, 2020-12, Vol.63 (24), p.15187-15217

2020

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Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

Science translational medicine, 2019-02, Vol.11 (478)

2019

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The sigma-1 receptor chaperone as an inter-organelle signaling modulator

Trends in pharmacological sciences (Regular ed.), 2010-12, Vol.31 (12), p.557-566

2010

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Fenfluramine acts as a positive modulator of sigma-1 receptors

Epilepsy & behavior, 2020-04, Vol.105, p.106989-106989, Article 106989

2020

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Development of easy-to-use reverse-phase liquid chromatographic methods for determining PRE-084, RC-33 and RC-34 in biological matrices. The first step for in vivo analysis of sigma1 receptor agonists

Biomedical chromatography, 2016-04, Vol.30 (4), p.645-651

2016

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Biochemical Pharmacology of the Sigma-1 Receptor

Molecular pharmacology, 2016-01, Vol.89 (1), p.142-153

2016

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The pharmacology of sigma-1 receptors

Pharmacology & therapeutics (Oxford), 2009-11, Vol.124 (2), p.195-206

2009

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Role of sigma-1 receptors in neurodegenerative diseases

Journal of pharmacological sciences, 2015-01, Vol.127 (1), p.17-29

2015

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The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

Biochemical journal, 2015-03, Vol.466 (2), p.263-271

2015

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Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression

Progress in neurobiology, 2013-01, Vol.100, p.15-29

Hashimoto, Kenji

2013

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Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

Science (American Association for the Advancement of Science), 2009-02, Vol.323 (5916), p.934-937

2009

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Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs

Journal of pharmacological sciences, 2015-01, Vol.127 (1), p.2-5

Hayashi, Teruo

2015

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Neuroprotection in non-transgenic and transgenic mouse models of Alzheimer's disease by positive modulation of σ 1 receptors

Pharmacological research, 2019-06, Vol.144, p.315

2019

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NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus

The Journal of neuroscience, 2014-08, Vol.34 (34), p.11325-11338

2014

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N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain

Neuropharmacology, 2021-07, Vol.192, p.108612, Article 108612

2021

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Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models

Science translational medicine, 2022-02, Vol.14 (631), p.eabh3763

2022

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Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases

International journal of molecular sciences, 2023-01, Vol.24 (3), p.1997

2023

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WLB-87848, a Selective σ 1 Receptor Agonist, with an Unusually Positioned NH Group as Positive Ionizable Moiety and Showing Neuroprotective Activity

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.9150

2024

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The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases

Current neuropharmacology, 2018-01, Vol.16 (1), p.97-116

2018

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Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice

ACS chemical neuroscience, 2017-08, Vol.8 (8), p.1801-1811

2017

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The Molecular Function of σ Receptors: Past, Present, and Future

Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo

Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use

Small Molecules Selectively Targeting Sigma‑1 Receptor for the Treatment of Neurological Diseases

Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

Fenfluramine acts as a positive modulator of sigma-1 receptors

Development of easy-to-use reverse-phase liquid chromatographic methods for determining PRE-084, RC-33 and RC-34 in biological matrices. The first step for in vivo analysis of sigma1 receptor agonists

Biochemical Pharmacology of the Sigma-1 Receptor

The pharmacology of sigma-1 receptors

Role of sigma-1 receptors in neurodegenerative diseases

The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression

Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs

Neuroprotection in non-transgenic and transgenic mouse models of Alzheimer's disease by positive modulation of σ 1 receptors

NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus

N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain

Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models

Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases

WLB-87848, a Selective σ 1 Receptor Agonist, with an Unusually Positioned NH Group as Positive Ionizable Moiety and Showing Neuroprotective Activity

The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases

Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice

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