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The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease

Pharmacological reviews, 2014-07, Vol.66 (3), p.638-675

2014

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The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

Nature (London), 2018-07, Vol.559 (7713), p.264-268

2018

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CD39 Limits P2X7 Receptor Inflammatory Signaling and Attenuates Sepsis-Induced Liver Injury

Journal of hepatology, 2017-10, Vol.67 (4), p.716-726

2017

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Structural and Functional Basis for Understanding the Biological Significance of P2X7 Receptor

International journal of molecular sciences, 2020-11, Vol.21 (22), p.8454

2020

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P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

Glia, 2014-04, Vol.62 (4), p.592-607

2014

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The long β2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors

The Journal of biological chemistry, 2022-06, Vol.298 (6), p.102002, Article 102002

2022

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P2X7 Receptor at the Crossroads of T Cell Fate

International journal of molecular sciences, 2020-07, Vol.21 (14), p.4937

2020

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P2X7 Receptor: A Potential Therapeutic Target for Depression?

Trends in molecular medicine, 2018-09, Vol.24 (9), p.736-747

2018

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The P2X7 Receptor

Advances in experimental medicine and biology, 2017, Vol.1051, p.17-53

2017

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A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

Nature communications, 2021-01, Vol.12 (1), p.653-653, Article 653

2021

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Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death

Scientific reports, 2015-11, Vol.5 (1), p.16222-16222, Article 16222

2015

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P2X7 receptor channels allow direct permeation of nanometer-sized dyes

The Journal of neuroscience, 2013-02, Vol.33 (8), p.3557-3566

2013

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P2X7 receptors: channels, pores and more

CNS & neurological disorders drug targets, 2012-09, Vol.11 (6), p.705-721

2012

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Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket

Molecular pharmacology, 2019-09, Vol.96 (3), p.355-363

2019

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A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury

The Journal of immunology (1950), 2016-10, Vol.197 (7), p.2828-2837

2016

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Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis

PloS one, 2020-06, Vol.15 (6), p.e0234038

2020

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P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer

Oncotarget, 2017-07, Vol.8 (30), p.48972-48982

2017

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The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation

The Journal of pathology, 2013-11, Vol.231 (3), p.342-353

2013

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Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages

Journal of leukocyte biology, 2016-02, Vol.99 (2), p.289-299

2016

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Activation of the purinergic receptor P2X7 improves hepatosteatosis by promoting lipophagy

FEBS letters, 2021-11, Vol.595 (22), p.2768-2780

2021

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P2X7 receptor deficiency attenuates cisplatin-induced kidney injury via inhibiting NLRP3 inflammasome activation

Biochemical pharmacology, 2024-08, Vol.226, p.116369, Article 116369

2024

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P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release

The FASEB journal, 2012-07, Vol.26 (7), p.2951-2962

2012

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Effect of P2X7 receptor on tumorigenesis and its pharmacological properties

Biomedicine & pharmacotherapy, 2020-05, Vol.125, p.109844, Article 109844

2020

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P2X7 receptor deletion suppresses γ-radiation-induced hyposalivation

American journal of physiology. Regulatory, integrative and comparative physiology, 2019-05, Vol.316 (5), p.R687-R696

2019

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Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120

Scientific reports, 2017-04, Vol.7 (1), p.725-12, Article 725

2017

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The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

CD39 Limits P2X7 Receptor Inflammatory Signaling and Attenuates Sepsis-Induced Liver Injury

Structural and Functional Basis for Understanding the Biological Significance of P2X7 Receptor

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

The long β2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors

P2X7 Receptor at the Crossroads of T Cell Fate

P2X7 Receptor: A Potential Therapeutic Target for Depression?

The P2X7 Receptor

A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death

P2X7 receptor channels allow direct permeation of nanometer-sized dyes

P2X7 receptors: channels, pores and more

Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket

A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury

Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis

P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer

The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation

Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages

Activation of the purinergic receptor P2X7 improves hepatosteatosis by promoting lipophagy

P2X7 receptor deficiency attenuates cisplatin-induced kidney injury via inhibiting NLRP3 inflammasome activation

P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release

Effect of P2X7 receptor on tumorigenesis and its pharmacological properties

P2X7 receptor deletion suppresses γ-radiation-induced hyposalivation

Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120

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