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Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

PloS one, 2017-07, Vol.12 (7), p.e0179431

2017

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The emerging role of anti‐CD25 directed therapies as both immune modulators and targeted agents in cancer

British journal of haematology, 2017-10, Vol.179 (1), p.20-35

2017

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Pharmacokinetics and Pharmacodynamic Effects of Nemvaleukin Alfa, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, in Cynomolgus Monkeys

The Journal of pharmacology and experimental therapeutics, 2021-11, Vol.379 (2), p.203-210

2021

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Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (26), p.11906-11911

2010

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Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

Nature (London), 2012-04, Vol.484 (7395), p.529-533

2012

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IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function

Cell reports (Cambridge), 2023-08, Vol.42 (8), p.112996-112996, Article 112996

2023

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Soluble IL-2Rα facilitates IL-2–mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma

Blood, 2011-09, Vol.118 (10), p.2809-2820

2011

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A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells

The Journal of immunology (1950), 2008-07, Vol.181 (1), p.225-234

2008

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CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells

The Journal of immunology (1950), 2019-07, Vol.203 (1), p.93-104

2019

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A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control

Nature communications, 2019-08, Vol.10 (1), p.3874-12, Article 3874

2019

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IL-2/IL-2 antibody immune complex regulates HSV-induced inflammation through induction of IL-2 receptor alpha, beta, and gamma in a mouse model

Immunobiology (1979), 2015-12, Vol.220 (12), p.1381-1392

2015

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NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

Clinical cancer research, 2016-02, Vol.22 (3), p.680-690

2016

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Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

Immunity (Cambridge, Mass.), 2013-01, Vol.38 (1), p.13-25

2013

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Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

Nature immunology, 2012-12, Vol.13 (12), p.1187-1195

2012

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Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

Immunity (Cambridge, Mass.), 2015-05, Vol.42 (5), p.826-838

2015

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High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity

Journal for immunotherapy of cancer, 2021-09, Vol.9 (9), p.e002865

2021

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Dendritic cell derived IL‐2 inhibits survival of terminally mature cells via an autocrine signaling pathway

European journal of immunology, 2015-05, Vol.45 (5), p.1494-1499

2015

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Central Role for Interleukin-2 in Type 1 Diabetes

Diabetes (New York, N.Y.), 2012-01, Vol.61 (1), p.14-22

2012

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Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

Immunity (Cambridge, Mass.), 2010-08, Vol.33 (2), p.153-165

2010

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An essential role for the IL-2 receptor in T reg cell function

Nature immunology, 2016-11, Vol.17 (11), p.1322

2016

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Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

Nature communications, 2019-03, Vol.10 (1), p.1037-1037, Article 1037

2019

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A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells

Molecular therapy, 2023-08, Vol.31 (8), p.2472-2488

2023

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Effect of nasopharyngeal carcinoma-derived exosomes on human regulatory T cells

JNCI : Journal of the National Cancer Institute, 2015-01, Vol.107 (1), p.363-363

2015

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Multivalent, asymmetric IL-2-Fc fusions show enhanced selectivity for regulatory T cells

Science signaling, 2023-10, Vol.16 (807), p.eadg0699

2023

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Endophilin marks and controls a clathrin-independent endocytic pathway

Nature (London), 2015-01, Vol.517 (7535), p.460-465

2015

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Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

The emerging role of anti‐CD25 directed therapies as both immune modulators and targeted agents in cancer

Pharmacokinetics and Pharmacodynamic Effects of Nemvaleukin Alfa, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, in Cynomolgus Monkeys

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function

Soluble IL-2Rα facilitates IL-2–mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma

A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells

CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control

IL-2/IL-2 antibody immune complex regulates HSV-induced inflammation through induction of IL-2 receptor alpha, beta, and gamma in a mouse model

NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity

Dendritic cell derived IL‐2 inhibits survival of terminally mature cells via an autocrine signaling pathway

Central Role for Interleukin-2 in Type 1 Diabetes

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

An essential role for the IL-2 receptor in T reg cell function

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells

Effect of nasopharyngeal carcinoma-derived exosomes on human regulatory T cells

Multivalent, asymmetric IL-2-Fc fusions show enhanced selectivity for regulatory T cells

Endophilin marks and controls a clathrin-independent endocytic pathway

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