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Muscarinic M1 and M4 receptor agonists for schizophrenia: promising candidates for the therapeutic arsenal

Expert opinion on investigational drugs, 2023-12, Vol.32 (12), p.1113-1121

Dean, Brian

2023

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Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

Nature neuroscience, 2011-01, Vol.14 (1), p.22-24

2011

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Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Neuropsychopharmacology (New York, N.Y.), 2014-06, Vol.39 (7), p.1578-1593

2014

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M 3 but not M 4 muscarinic receptors in the rostromedial tegmental nucleus are involved in the acquisition of morphine-induced conditioned place preference

European journal of pharmacology, 2020-09, Vol.882, p.173274

2020

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Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse

Neuropsychopharmacology (New York, N.Y.), 2016-03, Vol.41 (4), p.1014-1023

2016

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Striatal Muscarinic Receptors Promote Activity Dependence of Dopamine Transmission via Distinct Receptor Subtypes on Cholinergic Interneurons in Ventral versus Dorsal Striatum

The Journal of neuroscience, 2010-03, Vol.30 (9), p.3398-3408

2010

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Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites

Molecular pharmacology, 2020-01, Vol.97 (1), p.35-45

2020

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An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

Nature chemical biology, 2008, Vol.4 (1), p.42-50

2008

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Molecular Mechanisms of Action and In Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties

Neuropsychopharmacology (New York, N.Y.), 2010-03, Vol.35 (4), p.855-869

2010

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Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice

Naunyn-Schmiedeberg's archives of pharmacology, 2009-04, Vol.379 (4), p.389-395

2009

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Muscarinic acetylcholine M 4 receptors play a critical role in oxotremorine-induced DARPP-32 phosphorylation at threonine 75 in isolated medium spiny neurons

Neuropharmacology, 2017-05, Vol.117, p.376

2017

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Muscarinic control of rostromedial tegmental nucleus GABA neurons and morphine-induced locomotion

The European journal of neuroscience, 2016-07, Vol.44 (1), p.1761-1770

2016

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Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3029-3033

2016

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Monoamine Oxidase Inhibition by Major Tanshinones from Salvia miltiorrhiza and Selective Muscarinic Acetylcholine M 4 Receptor Antagonism by Tanshinone I

Biomolecules (Basel, Switzerland), 2021-07, Vol.11 (7)

2021

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Tracking the Time-Dependent Role of the Hippocampus in Memory Recall Using DREADDs

PloS one, 2016-05, Vol.11 (5), p.e0154374-e0154374

2016

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M2 muscarinic receptor activation regulates schwann cell differentiation and myelin organization

Developmental neurobiology (Hoboken, N.J.), 2014-07, Vol.74 (7), p.676-691

2014

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New insight into active muscarinic receptors with the novel radioagonist [3H]iperoxo

Biochemical pharmacology, 2014-08, Vol.90 (3), p.307-319

2014

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Enhanced self-administration of alcohol in muscarinic acetylcholine M4 receptor knockout mice

European journal of pharmacology, 2015-01, Vol.746, p.1-5

2015

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Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2 M4 muscarinic receptor knockout mice

Molecular psychiatry, 2003-07, Vol.8 (7), p.673-679

2003

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New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)

Molecular pharmacology, 2008-10, Vol.74 (4), p.1119

2008

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Discovery and Development of Muscarinic Acetylcholine M 4 Activators as Promising Therapeutic Agents for CNS Diseases

Chemical & pharmaceutical bulletin, 2018, Vol.66 (1), p.37

2018

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Impact of species variability and ‘probe‐dependence’ on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor

British journal of pharmacology, 2011-04, Vol.162 (7), p.1659-1670

2011

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Blockade of different muscarinic receptor subtypes changes the equilibrium between excitation and inhibition in rat visual cortex

Neuroscience, 2010-09, Vol.169 (4), p.1610-1620

2010

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Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Nature (London), 2016-03, Vol.531 (7594), p.335-340

2016

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Probing Structural Requirements of Positive Allosteric Modulators of the M4 Muscarinic Receptor

Journal of medicinal chemistry, 2013-10, Vol.56 (20), p.8196-8200

2013

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Muscarinic M1 and M4 receptor agonists for schizophrenia: promising candidates for the therapeutic arsenal

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

M 3 but not M 4 muscarinic receptors in the rostromedial tegmental nucleus are involved in the acquisition of morphine-induced conditioned place preference

Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse

Striatal Muscarinic Receptors Promote Activity Dependence of Dopamine Transmission via Distinct Receptor Subtypes on Cholinergic Interneurons in Ventral versus Dorsal Striatum

Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

Molecular Mechanisms of Action and In Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties

Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice

Muscarinic acetylcholine M 4 receptors play a critical role in oxotremorine-induced DARPP-32 phosphorylation at threonine 75 in isolated medium spiny neurons

Muscarinic control of rostromedial tegmental nucleus GABA neurons and morphine-induced locomotion

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

Monoamine Oxidase Inhibition by Major Tanshinones from Salvia miltiorrhiza and Selective Muscarinic Acetylcholine M 4 Receptor Antagonism by Tanshinone I

Tracking the Time-Dependent Role of the Hippocampus in Memory Recall Using DREADDs

M2 muscarinic receptor activation regulates schwann cell differentiation and myelin organization

New insight into active muscarinic receptors with the novel radioagonist [3H]iperoxo

Enhanced self-administration of alcohol in muscarinic acetylcholine M4 receptor knockout mice

Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2 M4 muscarinic receptor knockout mice

New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)

Discovery and Development of Muscarinic Acetylcholine M 4 Activators as Promising Therapeutic Agents for CNS Diseases

Impact of species variability and ‘probe‐dependence’ on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor

Blockade of different muscarinic receptor subtypes changes the equilibrium between excitation and inhibition in rat visual cortex

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Probing Structural Requirements of Positive Allosteric Modulators of the M4 Muscarinic Receptor

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