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Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Cell reports (Cambridge), 2021-08, Vol.36 (9), p.109648-109648, Article 109648

2021

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Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5

Molecular pharmacology, 2014-12, Vol.86 (6), p.774-785

2014

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An allosteric modulator to control endogenous G protein-coupled receptors with light

Nature chemical biology, 2014-10, Vol.10 (10), p.813-815

2014

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Structural insights into the activation of metabotropic glutamate receptors

Nature (London), 2019-02, Vol.566 (7742), p.79-84

2019

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Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery

Neuropharmacology, 2017-03, Vol.115, p.60-72

2017

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Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site

Biochemical pharmacology, 2020-07, Vol.177, p.114013, Article 114013

2020

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Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment

Neuropharmacology, 2017-03, Vol.115, p.73-91

2017

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Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)

The Journal of biological chemistry, 2014-10, Vol.289 (41), p.28460-28477

2014

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Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract

World journal of gastroenterology : WJG, 2017-07, Vol.23 (25), p.4500-4507

2017

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Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to descending pain facilitation in healthy and arthritic animals

Neuroscience, 2016-01, Vol.312, p.108-119

2016

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Activation of type 5 metabotropic glutamate receptor promotes the proliferation of rat retinal progenitor cell via activation of the PI-3-K and MAPK signaling pathways

Neuroscience, 2016-05, Vol.322, p.138-151

2016

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Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

Nature chemical biology, 2015-02, Vol.11 (2), p.134-140

2015

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Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis

Cell metabolism, 2019-11, Vol.30 (5), p.877

2019

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Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors

Acta pharmacologica Sinica, 2021-08, Vol.42 (8), p.1354-1367

2021

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Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

Current neuropharmacology, 2016-07, Vol.14 (5), p.441-454

2016

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Accumbens nNOS Interneurons Regulate Cocaine Relapse

The Journal of neuroscience, 2017-01, Vol.37 (4), p.742-756

2017

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Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation

Neuron (Cambridge, Mass.), 2019-10, Vol.104 (2), p.338-352.e7

2019

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Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease

Brain (London, England : 1878), 2016-02, Vol.139 (Pt 2), p.526-546

2016

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Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

PLoS pathogens, 2017-11, Vol.13 (11), p.e1006733

2017

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An antagonist-based two-photon fluorogenic probe for imaging metabotropic glutamate receptor 5 in neuronal cells

Talanta (Oxford), 2024-08, Vol.275, p.126167-126167, Article 126167

2024

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Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

Journal of neurochemistry, 2021-01, Vol.156 (2), p.225-248

2021

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Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer

Archives of biochemistry and biophysics, 2023-08, Vol.744, p.109698-109698, Article 109698

2023

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Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells

Biochemical and biophysical research communications, 2023-04, Vol.653, p.1-11

2023

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Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Bioorganic & medicinal chemistry letters, 2017-11, Vol.27 (21), p.4858-4866

2017

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Genetic disruption of Grm5 causes complex alterations in motor activity, anxiety and social behaviors

Behavioural brain research, 2021-08, Vol.411, p.113378-113378, Article 113378

2021

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Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5

An allosteric modulator to control endogenous G protein-coupled receptors with light

Structural insights into the activation of metabotropic glutamate receptors

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery

Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site

Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment

Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)

Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract

Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to descending pain facilitation in healthy and arthritic animals

Activation of type 5 metabotropic glutamate receptor promotes the proliferation of rat retinal progenitor cell via activation of the PI-3-K and MAPK signaling pathways

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis

Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

Accumbens nNOS Interneurons Regulate Cocaine Relapse

Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation

Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

An antagonist-based two-photon fluorogenic probe for imaging metabotropic glutamate receptor 5 in neuronal cells

Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer

Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells

Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Genetic disruption of Grm5 causes complex alterations in motor activity, anxiety and social behaviors

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