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Phosphatidylinositol 3-Kinase (PI3K) Activity Bound to Insulin-like Growth Factor-I (IGF-I) Receptor, which Is Continuously Sustained by IGF-I Stimulation, Is Required for IGF-I-induced Cell Proliferation

The Journal of biological chemistry, 2012-08, Vol.287 (35), p.29713-29721

2012

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Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation

Clinical endocrinology (Oxford), 2014-08, Vol.81 (2), p.312-314

2014

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Mutation at Cleavage Site of Insulin-Like Growth Factor Receptor in a Short-Stature Child Born with Intrauterine Growth Retardation

The journal of clinical endocrinology and metabolism, 2005-08, Vol.90 (8), p.4679-4687

2005

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Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation

Clinical endocrinology (Oxford), 2012-08, Vol.77 (2), p.246-254

2012

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AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Cancer cell, 2011-01, Vol.19 (1), p.58-71

2011

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Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer

Nature communications, 2020-09, Vol.11 (1), p.4607-14, Article 4607

2020

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The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells

Science signaling, 2013-08, Vol.6 (287), p.ra66

2013

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Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle

The Journal of clinical investigation, 2021-09, Vol.131 (18)

2021

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IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage

Journal of hepatology, 2010-04, Vol.52 (4), p.550-559

2010

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Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Nature communications, 2017-03, Vol.8 (1), p.14892-14892, Article 14892

2017

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Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

Nature communications, 2021-05, Vol.12 (1), p.2699-2699, Article 2699

2021

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Diversity of insulin and IGF signaling in breast cancer: Implications for therapy

Molecular and cellular endocrinology, 2021-05, Vol.527, p.111213-111213, Article 111213

2021

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Insulin‐like growth factor‐II and bioactive proteins containing a part of the E‐domain of pro‐insulin‐like growth factor‐II

BioFactors (Oxford), 2020-07, Vol.46 (4), p.563-578

Doorn, Jaap

2020

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MiR‐122 modification enhances the therapeutic efficacy of adipose tissue‐derived mesenchymal stem cells against liver fibrosis

Journal of cellular and molecular medicine, 2017-11, Vol.21 (11), p.2963-2973

2017

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Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity

Immunity (Cambridge, Mass.), 2020-04, Vol.52 (4), p.650-667.e10

2020

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Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

Circulation (New York, N.Y.), 2022-06, Vol.145 (25), p.1853-1866

2022

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miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach

Cardiovascular research, 2016-08, Vol.111 (3), p.184-193

2016

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Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

Cellular and molecular life sciences : CMLS, 2014-07, Vol.71 (13), p.2403-2427

2014

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Functionally significant insulin-like growth factor I receptor mutations in centenarians

Proceedings of the National Academy of Sciences - PNAS, 2008-03, Vol.105 (9), p.3438-3442

2008

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The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r

Nature cell biology, 2012-07, Vol.14 (7), p.659-665

2012

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Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor

The Journal of immunology (1950), 2014-01, Vol.192 (1), p.437-446

2014

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Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Nature communications, 2017-06, Vol.8 (1), p.15936-15936, Article 15936

2017

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A STAT3-based gene signature stratifies glioma patients for targeted therapy

Nature communications, 2019-08, Vol.10 (1), p.3601-15, Article 3601

2019

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Gaussian Mixture Models for Probabilistic Classification of Breast Cancer

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13), p.3492-3502

2019

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The emerging role of miR‐375 in cancer

International journal of cancer, 2014-09, Vol.135 (5), p.1011-1018

2014

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Phosphatidylinositol 3-Kinase (PI3K) Activity Bound to Insulin-like Growth Factor-I (IGF-I) Receptor, which Is Continuously Sustained by IGF-I Stimulation, Is Required for IGF-I-induced Cell Proliferation

Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation

Mutation at Cleavage Site of Insulin-Like Growth Factor Receptor in a Short-Stature Child Born with Intrauterine Growth Retardation

Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer

The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells

Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle

IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

Diversity of insulin and IGF signaling in breast cancer: Implications for therapy

Insulin‐like growth factor‐II and bioactive proteins containing a part of the E‐domain of pro‐insulin‐like growth factor‐II

MiR‐122 modification enhances the therapeutic efficacy of adipose tissue‐derived mesenchymal stem cells against liver fibrosis

Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

Functionally significant insulin-like growth factor I receptor mutations in centenarians

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r

Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

A STAT3-based gene signature stratifies glioma patients for targeted therapy

Gaussian Mixture Models for Probabilistic Classification of Breast Cancer

The emerging role of miR‐375 in cancer

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