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Current approaches to enhancing oxime reactivator delivery into the brain

Toxicology (Amsterdam), 2019-07, Vol.423, p.75-83

2019

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SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

Archives of toxicology, 2016-12, Vol.90 (12), p.2831-2859

2016

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From pyridinium-based to centrally active acetylcholinesterase reactivators

Mini reviews in medicinal chemistry, 2014-01, Vol.14 (3), p.215-221

2014

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Oximes in organophosphate poisoning: 60 years of hope and despair

Chemico-biological interactions, 2016-11, Vol.259 (Pt B), p.93-98

2016

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Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat

Toxicology (Amsterdam), 2020-11, Vol.444, p.152578, Article 152578

2020

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New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5743-5748

2014

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Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review

Mini reviews in medicinal chemistry, 2015-01, Vol.15 (1), p.58-72

2015

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Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates

Chemico-biological interactions, 2013-03, Vol.203 (1), p.135-138

2013

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Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase

Bioorganic & medicinal chemistry, 2017-08, Vol.25 (16), p.4497-4505

2017

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“RB-reactivator screening” as a novel cell-based assay for discoveries of molecular targeting agents including the first-in-class MEK inhibitor trametinib (trade name: Mekinist)

Pharmacology & therapeutics (Oxford), 2022-08, Vol.236, p.108234-108234, Article 108234

Sakai, Toshiyuki

2022

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Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents

Chemico-biological interactions, 2016-11, Vol.259 (Pt B), p.133-141

2016

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New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Biomolecules (Basel, Switzerland), 2024-06, Vol.14 (6), p.679

2024

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Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model

Colloids and surfaces, B, Biointerfaces, 2018-11, Vol.171, p.358-367

2018

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Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase

Journal of medicinal chemistry, 2017-11, Vol.60 (22), p.9376-9392

2017

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Novel tacrine-pyridinium hybrid reactivators of organophosphorus-inhibited acetylcholinesterase: Synthesis, molecular docking, and in vitro reactivation study

Bioorganic & medicinal chemistry letters, 2018-12, Vol.28 (23-24), p.3784-3786

2018

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HI-6-Loaded Vehicle of Liposomes Mediated by an Amphiphilic Pillar[5]arene against Paraoxon Poisoning

ACS applied materials & interfaces, 2024-09, Vol.16 (38), p.50474-50483

2024

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Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX

Chemico-biological interactions, 2016-11, Vol.259 (Pt B), p.154-159

2016

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Progress in the development of enzyme-based nerve agent bioscavengers

Chemico-biological interactions, 2013-12, Vol.206 (3), p.536-544

2013

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Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

The Journal of biological chemistry, 2020-03, Vol.295 (13), p.4079-4092

2020

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No-observed-adverse-effect-level (NOAEL) assessment as an optimized dose of cholinesterase reactivators for the treatment of exposure to warfare nerve agents in mice

Chemico-biological interactions, 2024-04, Vol.392, p.110929-110929, Article 110929

2024

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Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents

Chemico-biological interactions, 2013-03, Vol.203 (1), p.81-84

2013

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Countermeasures in organophosphorus intoxication: pitfalls and prospects

Trends in pharmacological sciences (Regular ed.), 2022-07, Vol.43 (7), p.593-606

2022

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Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus

Toxicological sciences, 2019-06, Vol.169 (2), p.465-474

2019

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Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro

Toxicology letters, 2018-12, Vol.299, p.218-225

2018

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A brief survey on the advanced brain drug administration by nanoscale carriers: With a particular focus on AChE reactivators

Life sciences (1973), 2020-01, Vol.240, p.117099-117099, Article 117099

2020

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Current approaches to enhancing oxime reactivator delivery into the brain

SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

From pyridinium-based to centrally active acetylcholinesterase reactivators

Oximes in organophosphate poisoning: 60 years of hope and despair

Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat

New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase

Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review

Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates

Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase

“RB-reactivator screening” as a novel cell-based assay for discoveries of molecular targeting agents including the first-in-class MEK inhibitor trametinib (trade name: Mekinist)

Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents

New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model

Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase

Novel tacrine-pyridinium hybrid reactivators of organophosphorus-inhibited acetylcholinesterase: Synthesis, molecular docking, and in vitro reactivation study

HI-6-Loaded Vehicle of Liposomes Mediated by an Amphiphilic Pillar[5]arene against Paraoxon Poisoning

Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX

Progress in the development of enzyme-based nerve agent bioscavengers

Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

No-observed-adverse-effect-level (NOAEL) assessment as an optimized dose of cholinesterase reactivators for the treatment of exposure to warfare nerve agents in mice

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents

Countermeasures in organophosphorus intoxication: pitfalls and prospects

Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus

Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro

A brief survey on the advanced brain drug administration by nanoscale carriers: With a particular focus on AChE reactivators

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