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Design, synthesis, and preclinical evaluation of 11C/18F-labeled inhibitors for RIPK1 PET imaging

European journal of medicinal chemistry, 2024-12, Vol.279, p.116851, Article 116851

2024

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Structure-based discovery of a 4,5-Dihydropyrazole-cored PET ligand for imaging of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in the brain

European journal of medicinal chemistry, 2024-12, Vol.279, p.116803, Article 116803

2024

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RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis

Molecular biology reports, 2024-12, Vol.51 (1), p.524-524, Article 524

2024

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Necroptosis in alveolar epithelial cells drives lung inflammation and injury caused by SARS-CoV-2 infection

Biochimica et biophysica acta. Molecular basis of disease, 2024-12, Vol.1870 (8), p.167472, Article 167472

2024

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The protective role of Cordyceps cicadae and its active ingredient myriocin against sodium iodate-induced age-related macular degeneration via an anti-necroptotic TNF-RIPK1/3 pathway

Journal of ethnopharmacology, 2024-11, Vol.334, p.118565, Article 118565

2024

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Aerobic exercise modulates RIPK1-mediated MAP3K5/JNK and NF-κB pathways to suppress microglia activation and neuroinflammation in the hippocampus of D-gal-induced accelerated aging mice

Physiology & behavior, 2024-11, Vol.286, p.114676, Article 114676

2024

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O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma

Drug resistance updates, 2024-11, Vol.77, p.101150, Article 101150

2024

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Discovery and optimization of 3‐(indolin‐5‐yloxy)pyridin‐2‐amine derivatives as potent necroptosis inhibitors

Archiv der Pharmazie (Weinheim), 2024-10, Vol.357 (10), p.e2400302-n/a

2024

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Receptor-interacting protein kinase 1 confers autophagic promotion of gasdermin E-mediated pyroptosis in aristolochic acid-induced acute kidney injury

Ecotoxicology and environmental safety, 2024-10, Vol.284, p.116944, Article 116944

2024

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Deubiquitinase USP5 regulates RIPK1 driven pyroptosis in response to myocardial ischemic reperfusion injury

Cell communication and signaling, 2024-09, Vol.22 (1), p.466-14, Article 466

2024

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Harnessing dual-mode RIPK1 ligands for cross-species anti-necroptosis inhibitor compounds

Bioorganic & medicinal chemistry letters, 2024-09, Vol.113, p.129970, Article 129970

2024

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RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression

Cell communication and signaling, 2024-09, Vol.22 (1), p.427-17, Article 427

2024

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Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis

The Journal of biological chemistry, 2024-09, Vol.300 (9), p.107676, Article 107676

2024

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Bifunctional halloysite nanotube-based Ripk1 siRNA delivery system rescues cognitive impairment by targeting amyloid β plaques for clearance and reducing necrotic neurons in Alzheimer’s disease mice

Chemical engineering journal (Lausanne, Switzerland : 1996), 2024-09, Vol.495, p.153460, Article 153460

2024

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Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19: A multicenter, randomized, double-blind, phase 1b trial

Journal of intensive medicine, 2024-09

2024

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RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia

Molecular metabolism (Germany), 2024-09, Vol.87, p.101988, Article 101988

2024

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Ripks and Neuroinflammation

Molecular neurobiology, 2024-09, Vol.61 (9), p.6771-6787

2024

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Targeting necroptosis: a promising avenue for respiratory disease treatment

Cell communication and signaling, 2024-08, Vol.22 (1), p.418-23

2024

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Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection

Cell reports (Cambridge), 2024-08, Vol.43 (8), p.114641, Article 114641

2024

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METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium

Cell regeneration, 2024-08, Vol.13 (1), p.14-15, Article 14

2024

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BECN1 regulates FADD/RIPK1/Caspase-8 complex formation via RIPK1 ubiquitination by downregulating OTUD1 in MI/R induced myocyte apoptosis

International journal of cardiology, 2024-08, Vol.408, p.132158-132158, Article 132158

2024

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Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response

Immunologic research, 2024-08, Vol.72 (4), p.841-850

2024

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Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer's Disease

Advanced science, 2024-08, Vol.11 (32), p.e2309021-n/a

2024

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Discovery of 5‐(1‐benzyl‐1H‐imidazol‐4‐yl)‐1,2,4‐oxadiazole derivatives as novel RIPK1 inhibitors via structure‐based virtual screening

Drug development research, 2024-08, Vol.85 (5), p.e22235-n/a

2024

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Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis

Cell communication and signaling, 2024-07, Vol.22 (1), p.372-19, Article 372

2024

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Design, synthesis, and preclinical evaluation of 11C/18F-labeled inhibitors for RIPK1 PET imaging

Structure-based discovery of a 4,5-Dihydropyrazole-cored PET ligand for imaging of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in the brain

RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis

Necroptosis in alveolar epithelial cells drives lung inflammation and injury caused by SARS-CoV-2 infection

The protective role of Cordyceps cicadae and its active ingredient myriocin against sodium iodate-induced age-related macular degeneration via an anti-necroptotic TNF-RIPK1/3 pathway

Aerobic exercise modulates RIPK1-mediated MAP3K5/JNK and NF-κB pathways to suppress microglia activation and neuroinflammation in the hippocampus of D-gal-induced accelerated aging mice

O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma

Discovery and optimization of 3‐(indolin‐5‐yloxy)pyridin‐2‐amine derivatives as potent necroptosis inhibitors

Receptor-interacting protein kinase 1 confers autophagic promotion of gasdermin E-mediated pyroptosis in aristolochic acid-induced acute kidney injury

Deubiquitinase USP5 regulates RIPK1 driven pyroptosis in response to myocardial ischemic reperfusion injury

Harnessing dual-mode RIPK1 ligands for cross-species anti-necroptosis inhibitor compounds

RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression

Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis

Bifunctional halloysite nanotube-based Ripk1 siRNA delivery system rescues cognitive impairment by targeting amyloid β plaques for clearance and reducing necrotic neurons in Alzheimer’s disease mice

Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19: A multicenter, randomized, double-blind, phase 1b trial

RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia

Ripks and Neuroinflammation

Targeting necroptosis: a promising avenue for respiratory disease treatment

Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection

METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium

BECN1 regulates FADD/RIPK1/Caspase-8 complex formation via RIPK1 ubiquitination by downregulating OTUD1 in MI/R induced myocyte apoptosis

Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response

Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer's Disease

Discovery of 5‐(1‐benzyl‐1H‐imidazol‐4‐yl)‐1,2,4‐oxadiazole derivatives as novel RIPK1 inhibitors via structure‐based virtual screening

Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis

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