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Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

International journal of molecular sciences, 2018-06, Vol.19 (6), p.1668

2018

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Metabolic Activation of Pyrrolizidine Alkaloids: Insights into the Structural and Enzymatic Basis

Chemical research in toxicology, 2014-06, Vol.27 (6), p.1030-1039

2014

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Pyrrolizidine alkaloids: occurrence, biology, and chemical synthesis

Natural product reports, 2017-01, Vol.34 (1), p.62-89

2017

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Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China

Acta pharmacologica Sinica, 2021-08, Vol.42 (8), p.1212-1222

2021

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Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines

Toxicology letters, 2016-11, Vol.263, p.44-57

2016

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Analytical strategies for the determination of pyrrolizidine alkaloids in plant based food and examination of the transfer rate during the infusion process

Food chemistry, 2018-11, Vol.266, p.514-523

2018

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Pyrrolizidine alkaloids

Natural product reports, 2014-12, Vol.31 (12), p.1721-1788

2014

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Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum

Journal of hepatology, 2011-04, Vol.54 (4), p.666-673

2011

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Pyrrolizidine alkaloids and beehive products: A review

Food chemistry, 2021-04, Vol.342, p.128384, Article 128384

2021

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Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells

Food and chemical toxicology, 2018-11, Vol.121, p.72-81

2018

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Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells

International journal of molecular sciences, 2021-04, Vol.22 (8), p.3821

2021

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Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human

Archives of toxicology, 2021-10, Vol.95 (10), p.3191-3204

2021

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Nursing protects honeybee larvae from secondary metabolites of pollen

Proceedings of the Royal Society. B, Biological sciences, 2018-03, Vol.285 (1875), p.20172849-20172849

Royal Society (Great Britain), 2018

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Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine

Journal of natural products (Washington, D.C.), 2016-02, Vol.79 (2), p.281-292

2016

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Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids

Archives of toxicology, 2019-08, Vol.93 (8), p.2197-2209

2019

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Utilization of a novel human hepatocyte-endothelial cell coculture model to determine differential toxicities of pyrrolizidine alkaloid food contaminants

Food and chemical toxicology, 2024-05, Vol.187, p.114584-114584, Article 114584

2024

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The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides

Planta medica, 2022-02, Vol.88 (2), p.130

2022

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Feeding on Host Plants with Different Concentrations and Structures of Pyrrolizidine Alkaloids Impacts the Chemical-Defense Effectiveness of a Specialist Herbivore

PloS one, 2015-10, Vol.10 (10), p.e0141480-e0141480

2015

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Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment-A Workshop Report

Planta medica, 2022-02, Vol.88 (2), p.98

2022

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Pyrrolizidine alkaloids in borage (Borago officinalis): Comprehensive profiling and development of a validated LC-MS/MS method for quantification

Talanta (Oxford), 2023-06, Vol.258, p.124425-124425, Article 124425

2023

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Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review

Toxins, 2020-05, Vol.12 (5), p.320

2020

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Simultaneous determination of eight pyrrolizidine alkaloids in various parts of Eupatorium lindleyanum by ultra high performance liquid chromatography tandem mass spectrometry and risk assessments based on a real‐life exposure scenario

Journal of separation science, 2021-09, Vol.44 (17), p.3237-3247

2021

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Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids

Journal of Chromatography A, 2017-06, Vol.1503, p.38-48

2017

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The chemical structure impairs the intensity of genotoxic effects promoted by 1,2-unsaturated pyrrolizidine alkaloids in vitro

Food and chemical toxicology, 2022-06, Vol.164, p.113049-113049, Article 113049

2022

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In vitro biotransformation of pyrrolizidine alkaloids in different species: part II—identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids

Archives of toxicology, 2020-11, Vol.94 (11), p.3759-3774

2020

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Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

Metabolic Activation of Pyrrolizidine Alkaloids: Insights into the Structural and Enzymatic Basis

Pyrrolizidine alkaloids: occurrence, biology, and chemical synthesis

Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China

Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines

Analytical strategies for the determination of pyrrolizidine alkaloids in plant based food and examination of the transfer rate during the infusion process

Pyrrolizidine alkaloids

Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum

Pyrrolizidine alkaloids and beehive products: A review

Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells

Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells

Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human

Nursing protects honeybee larvae from secondary metabolites of pollen

Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine

Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids

Utilization of a novel human hepatocyte-endothelial cell coculture model to determine differential toxicities of pyrrolizidine alkaloid food contaminants

The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides

Feeding on Host Plants with Different Concentrations and Structures of Pyrrolizidine Alkaloids Impacts the Chemical-Defense Effectiveness of a Specialist Herbivore

Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment-A Workshop Report

Pyrrolizidine alkaloids in borage (Borago officinalis): Comprehensive profiling and development of a validated LC-MS/MS method for quantification

Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review

Simultaneous determination of eight pyrrolizidine alkaloids in various parts of Eupatorium lindleyanum by ultra high performance liquid chromatography tandem mass spectrometry and risk assessments based on a real‐life exposure scenario

Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids

The chemical structure impairs the intensity of genotoxic effects promoted by 1,2-unsaturated pyrrolizidine alkaloids in vitro

In vitro biotransformation of pyrrolizidine alkaloids in different species: part II—identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids

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