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Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight

Diabetes (New York, N.Y.), 2017-04, Vol.66 (4), p.1062-1073

2017

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A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.566

2018

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Cancer Selective Target Degradation by Folate-Caged PROTACs

Journal of the American Chemical Society, 2021-05, Vol.143 (19), p.7380-7387

2021

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Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

Journal of medicinal chemistry, 2019-02, Vol.62 (3), p.1420-1442

2019

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Expedited Approach toward the Rational Design of Noncovalent SARS-CoV‑2 Main Protease Inhibitors

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2848-2865

2022

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VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

The New England journal of medicine, 2018-10, Vol.379 (17), p.1612-1620

2018

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Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5979-5983

2013

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Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

Cell research, 2020-08, Vol.30 (8), p.678-692

2020

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Givosiran: First Approval

Drugs (New York, N.Y.), 2020-02, Vol.80 (3), p.335-339

Scott, Lesley J.

2020

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Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein

Journal of medicinal chemistry, 2020-07, Vol.63 (14), p.7510-7528

2020

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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

Nature communications, 2020-09, Vol.11 (1), p.4659-14, Article 4659

2020

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Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2819-2839

2017

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Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid, Givosiran, in Patients With Acute Hepatic Porphyria

Clinical pharmacology and therapeutics, 2020-07, Vol.108 (1), p.63-72

2020

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VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

The New England journal of medicine, 2018-10, Vol.379 (17), p.1599-1611

2018

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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9062-9084

2018

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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)‑1-((S)‑2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy‑N‑(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.599-618

2018

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Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.2228-2241

2021

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In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir

Antimicrobial agents and chemotherapy, 2017-05, Vol.61 (5)

2017

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Improved SARS-CoV-2 M pro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

European journal of medicinal chemistry, 2021-10, Vol.222, p.113584

2021

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Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents

European journal of medicinal chemistry, 2020-01, Vol.186, p.111863, Article 111863

2020

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Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Nature communications, 2020-08, Vol.11 (1), p.4282-8, Article 4282

2020

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TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

Journal of microbiology, immunology and infection, 2020-06, Vol.53 (3), p.368-370

2020

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Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis

Leukemia, 2021-01, Vol.35 (1), p.1-17

2021

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Novel spirooxindole–pyrrolidine compounds: Synthesis, anticancer and molecular docking studies

European journal of medicinal chemistry, 2014-03, Vol.74, p.50-64

2014

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SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats

Toxicology and applied pharmacology, 2017-10, Vol.333, p.43-50

2017

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Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

Cancer Selective Target Degradation by Folate-Caged PROTACs

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

Expedited Approach toward the Rational Design of Noncovalent SARS-CoV‑2 Main Protease Inhibitors

VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

Givosiran: First Approval

Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid, Givosiran, in Patients With Acute Hepatic Porphyria

VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof

In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir

Improved SARS-CoV-2 M pro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis

Novel spirooxindole–pyrrolidine compounds: Synthesis, anticancer and molecular docking studies

SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats

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