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Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Nature (London), 2015-03, Vol.519 (7541), p.102-105

2015

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Myeloid neoplasms with eosinophilia

Blood, 2017-02, Vol.129 (6), p.704-714

2017

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The Capable ABL: What Is Its Biological Function?

Molecular and cellular biology, 2014-04, Vol.34 (7), p.1188-1197

Wang, Jean Y. J.

2014

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ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice

Gastroenterology (New York, N.Y. 1943), 2020-07, Vol.159 (1), p.289-305.e16

2020

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Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

The Journal of clinical investigation, 2016-08, Vol.126 (8), p.2970-2988

2016

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Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

Cancer cell, 2018-08, Vol.34 (2), p.271-285.e7

2018

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Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial

The lancet oncology, 2010-11, Vol.11 (11), p.1029-1035

2010

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Dual-modal label-free genosensor based on hemoglobin@gold nanocluster stabilized graphene nanosheets for the electrochemical detection of BCR/ABL fusion gene

Talanta (Oxford), 2020-09, Vol.217, p.121093, Article 121093

2020

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c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

Human molecular genetics, 2014-06, Vol.23 (11), p.2858-2879

2014

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Activation of tyrosine kinases by mutation of the gatekeeper threonine

Nature structural & molecular biology, 2008-10, Vol.15 (10), p.1109-1118

2008

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Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions

The Journal of cell biology, 2014-04, Vol.205 (2), p.251-263

2014

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c-Abl Stabilizes HDAC2 Levels by Tyrosine Phosphorylation Repressing Neuronal Gene Expression in Alzheimer’s Disease

Molecular cell, 2014-10, Vol.56 (1), p.163-173

2014

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Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy

Blood, 2024-08, Vol.144 (9), p.1022-1026

2024

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De-escalation of tyrosine kinase inhibitor therapy before complete treatment discontinuation in patients with chronic myeloid leukaemia (DESTINY): a non-randomised, phase 2 trial

The Lancet. Haematology, 2019-07, Vol.6 (7), p.e375-e383

2019

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Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification

Science (American Association for the Advancement of Science), 2001-08, Vol.293 (5531), p.876-880

2001

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Predicting Mutation-Induced Allosteric Changes in Structures and Conformational Ensembles of the ABL Kinase Using AlphaFold2 Adaptations with Alanine Sequence Scanning

International journal of molecular sciences, 2024-09, Vol.25 (18), p.10082

2024

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Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative

The Journal of biological chemistry, 2021-01, Vol.296, p.100449-100449, Article 100449

2021

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Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases

The Journal of clinical investigation, 2017-10, Vol.127 (10), p.3810-3826

2017

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c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty

Structure (London), 2007-03, Vol.15 (3), p.299-311

2007

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Asciminib antagonizes transplantable BCR::ABL1-positive lymphoid blast crisis in vivo by targeting malignant stem cells

Leukemia, 2024-08, Vol.38 (8), p.1825-1830

2024

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Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease

Biochimica et biophysica acta. Molecular basis of disease, 2018-04, Vol.1864 (4), p.1148-1159

2018

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The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

Myeloid neoplasms with eosinophilia

The Capable ABL: What Is Its Biological Function?

Molecular classification improves risk assessment in adult BCR-ABL1–negative B-ALL

ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial

Dual-modal label-free genosensor based on hemoglobin@gold nanocluster stabilized graphene nanosheets for the electrochemical detection of BCR/ABL fusion gene

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

Activation of tyrosine kinases by mutation of the gatekeeper threonine

Efficacy of tyrosine kinase inhibitors in Ph-like acute lymphoblastic leukemia harboring ABL-class rearrangements

Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions

c-Abl Stabilizes HDAC2 Levels by Tyrosine Phosphorylation Repressing Neuronal Gene Expression in Alzheimer’s Disease

Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy

De-escalation of tyrosine kinase inhibitor therapy before complete treatment discontinuation in patients with chronic myeloid leukaemia (DESTINY): a non-randomised, phase 2 trial

Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification

Predicting Mutation-Induced Allosteric Changes in Structures and Conformational Ensembles of the ABL Kinase Using AlphaFold2 Adaptations with Alanine Sequence Scanning

Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative

Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases

c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty

Asciminib antagonizes transplantable BCR::ABL1-positive lymphoid blast crisis in vivo by targeting malignant stem cells

Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease

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