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Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction

Biophysical chemistry, 2017-10, Vol.229, p.11-18

2017

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Protein Misfolding Diseases

Annual review of biochemistry, 2017-06, Vol.86, p.21

Hartl, F Ulrich

2017

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A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation

Molecular cell, 2018-05, Vol.70 (4), p.588-601.e6

2018

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Structural Studies of Amyloid Proteins at the Molecular Level

Annual review of biochemistry, 2017-06, Vol.86, p.69

2017

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Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

Molecular cell, 2015-10, Vol.60 (2), p.208-219

2015

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Mechanisms and Functions of Spatial Protein Quality Control

Annual review of biochemistry, 2017-06, Vol.86, p.97

2017

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An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease

Nature genetics, 2020-10, Vol.52 (10), p.1024-1035

2020

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The emerging role of α-synuclein truncation in aggregation and disease

The Journal of biological chemistry, 2020-07, Vol.295 (30), p.10224-10244

2020

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Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

Scientific reports, 2016-10, Vol.6 (1), p.34477-34477, Article 34477

2016

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Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (50), p.31882-31890

2020

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Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

Nature communications, 2019-06, Vol.10 (1), p.2479-2479, Article 2479

2019

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Cryo-EM structures of four polymorphic TDP-43 amyloid cores

Nature structural & molecular biology, 2019-07, Vol.26 (7), p.619

2019

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Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

Nature medicine, 2018-12, Vol.24 (12), p.1910-1918

2018

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A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

The EMBO journal, 2018-03, Vol.37 (5), p.n/a

2018

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Amyloidogenesis of Tau protein

Protein science, 2017-11, Vol.26 (11), p.2126-2150

2017

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C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy

Science translational medicine, 2020-09, Vol.12 (559)

2020

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Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

Nature (London), 2017-04, Vol.544 (7650), p.367-371

2017

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Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

Molecular cell, 2020-12, Vol.80 (5), p.779-795.e10

2020

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Proteostasis impairment in protein-misfolding and -aggregation diseases

Trends in cell biology, 2014-09, Vol.24 (9), p.506-514

2014

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LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Acta neuropathologica, 2019-06, Vol.137 (6), p.961-980

2019

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Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

Neurobiology of disease, 2018-01, Vol.109 (Pt B), p.209-218

2018

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Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

Proceedings of the National Academy of Sciences - PNAS, 2016-09, Vol.113 (37), p.10328-10333

2016

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RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy

Brain (London, England : 1878), 2019-12, Vol.142 (12), p.3753-3770

2019

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Small heat shock proteins: Role in cellular functions and pathology

Biochimica et biophysica acta, 2015-04, Vol.1854 (4), p.291-319

2015

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Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction

Protein Misfolding Diseases

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation

Structural Studies of Amyloid Proteins at the Molecular Level

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

Mechanisms and Functions of Spatial Protein Quality Control

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease

The emerging role of α-synuclein truncation in aggregation and disease

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

Cryo-EM structures of four polymorphic TDP-43 amyloid cores

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

Amyloidogenesis of Tau protein

C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

Proteostasis impairment in protein-misfolding and -aggregation diseases

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy

Small heat shock proteins: Role in cellular functions and pathology

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