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Determination of differentially regulated proteins upon proteasome inhibition in AML cell lines by the combination of large‐scale and targeted quantitative proteomics

Proteomics (Weinheim), 2017-04, Vol.17 (7), p.np-n/a

2017

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A Practical Review of Proteasome Pharmacology

Pharmacological reviews, 2019-04, Vol.71 (2), p.170-197

2019

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Nature communications, 2017-10, Vol.8 (1), p.830-14, Article 830

2017

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Small-molecule-induced polymerization triggers degradation of BCL6

Nature (London), 2020-12, Vol.588 (7836), p.164-168

2020

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The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges

Pharmacology & therapeutics (Oxford), 2020-09, Vol.213, p.107579-107579, Article 107579

2020

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Immunoproteasome-selective and non-selective inhibitors: A promising approach for the treatment of multiple myeloma

Pharmacology & therapeutics (Oxford), 2018-02, Vol.182, p.176-192

2018

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Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

Nature medicine, 2016-01, Vol.22 (1), p.46-53

2016

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In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome

Molecular cell, 2017-05, Vol.66 (4), p.488-502.e7

2017

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Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11218-11231

2019

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Spectrum and functional validation of PSMB5 mutations in multiple myeloma

Leukemia, 2019-02, Vol.33 (2), p.447-456

2019

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26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (10), p.4228-4237

2019

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Bardoxolone conjugation enables targeted protein degradation of BRD4

Scientific reports, 2020-09, Vol.10 (1), p.15543, Article 15543

2020

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ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

Biochemical journal, 2013-09, Vol.454 (2), p.201-208

2013

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A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

Cancer cell, 2014-01, Vol.25 (1), p.77-90

2014

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Development of proteasome inhibitors as research tools and cancer drugs

The Journal of cell biology, 2012-11, Vol.199 (4), p.583-588

Goldberg, Alfred L

2012

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Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

Nature cell biology, 2016-08, Vol.18 (8), p.897-909

2016

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Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway

European journal of medicinal chemistry, 2018-02, Vol.146, p.251-259

2018

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A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

Molecular & cellular proteomics, 2011-10, Vol.10 (10), p.M111.013284-M111.013284, Article M111.013284

2011

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Haematopoietic stem cells require a highly regulated protein synthesis rate

Nature (London), 2014-05, Vol.509 (7498), p.49-54

2014

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Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation

Nature medicine, 2017-09, Vol.23 (9), p.1055-1062

2017

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The immunoproteasome: a novel drug target for autoimmune diseases

Clinical and experimental rheumatology, 2015-07, Vol.33 (4 Suppl 92), p.S74

2015

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A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

Nature communications, 2021-07, Vol.12 (1), p.4358-4358, Article 4358

2021

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A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

Theranostics, 2021-01, Vol.11 (11), p.5279-5295

2021

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Determination of differentially regulated proteins upon proteasome inhibition in AML cell lines by the combination of large‐scale and targeted quantitative proteomics

A Practical Review of Proteasome Pharmacology

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Small-molecule-induced polymerization triggers degradation of BCL6

The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Immunoproteasome-selective and non-selective inhibitors: A promising approach for the treatment of multiple myeloma

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands

Spectrum and functional validation of PSMB5 mutations in multiple myeloma

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

Bardoxolone conjugation enables targeted protein degradation of BRD4

ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

Development of proteasome inhibitors as research tools and cancer drugs

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

Haematopoietic stem cells require a highly regulated protein synthesis rate

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation

The immunoproteasome: a novel drug target for autoimmune diseases

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

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