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Structure and the Mode of Activity of Lon Proteases from Diverse Organisms

Journal of molecular biology, 2022-04, Vol.434 (7), p.167504-167504, Article 167504

2022

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Degradation of Lon in Caulobacter crescentus

Journal of bacteriology, 2020-12, Vol.203 (1), p.1

2020

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Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (43), p.18410-18415

2010

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Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA+ Lon Protease

Molecular cell, 2013-01, Vol.49 (1), p.121-132

2013

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Cryo‐EM structure of the full‐length Lon protease from Thermus thermophilus

FEBS letters, 2021-11, Vol.595 (21), p.2691-2700

2021

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Emerging role of Lon protease as a master regulator of mitochondrial functions

Biochimica et biophysica acta, 2016-08, Vol.1857 (8), p.1300-1306

2016

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Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer

Cellular and Molecular Life Sciences, 2015-12, Vol.72 (24), p.4807-4824

2015

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c-di-GMP inhibits LonA-dependent proteolysis of TfoY in Vibrio cholerae

PLoS genetics, 2020-06, Vol.16 (6), p.e1008897

2020

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LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development

Development (Cambridge), 2022-03, Vol.149 (6)

2022

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Low Cytoplasmic Magnesium Increases the Specificity of the Lon and ClpAP Proteases

Journal of bacteriology, 2021-06, Vol.203 (14), p.e0014321-e0014321

2021

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An Integrated Proteomic Approach Uncovers Novel Substrates and Functions of the Lon Protease in Escherichia coli

Proteomics (Weinheim), 2018-07, Vol.18 (13), p.e1800080-n/a

2018

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Essential roles of Lon protease in the morpho-physiological traits of the rice pathogen Burkholderia glumae

PloS one, 2021-09, Vol.16 (9), p.e0257257

2021

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Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer

Oncotarget, 2014-11, Vol.5 (22), p.11209-11224

2014

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The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

Blood, 2012-04, Vol.119 (14), p.3321-3329

2012

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Distinct quaternary structures of the AAA+ Lon protease control substrate degradation

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (22), p.E2002-E2008

2013

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Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain

PloS one, 2012-05, Vol.7 (5), p.e38138

2012

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Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber

The EMBO journal, 2010-10, Vol.29 (20), p.3520-3530

2010

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Regulation of the general stress response sigma factor σ T by Lon-mediated proteolysis

Journal of bacteriology, 2023-11, Vol.205 (11), p.e0022823

2023

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Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements

The Journal of biological chemistry, 2022-03, Vol.298 (3), p.101694-101694, Article 101694

2022

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Multitasking in the mitochondrion by the ATP-dependent Lon protease

Biochimica et biophysica acta, 2012-01, Vol.1823 (1), p.56-66

2012

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Antiviral signalling by a cyclic nucleotide activated CRISPR protease

Nature (London), 2023-02, Vol.614 (7946), p.168-174

2023

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A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease

Archives of biochemistry and biophysics, 2021-10, Vol.710, p.108983-108983, Article 108983

2021

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Proteolytic control of FixT by the Lon protease impacts FixLJ signaling in Caulobacter crescentus

Journal of bacteriology, 2024-07, Vol.206 (7), p.e0023724

2024

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Lon protease downregulates phenazine‐1‐carboxamide biosynthesis by degrading the quorum sensing signal synthase PhzI and exhibits negative feedback regulation of Lon itself in Pseudomonas chlororaphis HT66

Molecular microbiology, 2021-08, Vol.116 (2), p.690-706

2021

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Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases

International journal of molecular sciences, 2022-09, Vol.23 (19), p.11425

2022

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Structure and the Mode of Activity of Lon Proteases from Diverse Organisms

Degradation of Lon in Caulobacter crescentus

Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)

Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA+ Lon Protease

Cryo‐EM structure of the full‐length Lon protease from Thermus thermophilus

Emerging role of Lon protease as a master regulator of mitochondrial functions

Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer

c-di-GMP inhibits LonA-dependent proteolysis of TfoY in Vibrio cholerae

LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development

Low Cytoplasmic Magnesium Increases the Specificity of the Lon and ClpAP Proteases

An Integrated Proteomic Approach Uncovers Novel Substrates and Functions of the Lon Protease in Escherichia coli

Essential roles of Lon protease in the morpho-physiological traits of the rice pathogen Burkholderia glumae

Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

Distinct quaternary structures of the AAA+ Lon protease control substrate degradation

Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain

Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber

Regulation of the general stress response sigma factor σ T by Lon-mediated proteolysis

Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements

Multitasking in the mitochondrion by the ATP-dependent Lon protease

Antiviral signalling by a cyclic nucleotide activated CRISPR protease

A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease

Proteolytic control of FixT by the Lon protease impacts FixLJ signaling in Caulobacter crescentus

Lon protease downregulates phenazine‐1‐carboxamide biosynthesis by degrading the quorum sensing signal synthase PhzI and exhibits negative feedback regulation of Lon itself in Pseudomonas chlororaphis HT66

Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases

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