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Cryo-EM structure of an amyloid fibril formed by full-length human prion protein

Nature structural & molecular biology, 2020-06, Vol.27 (6), p.598

2020

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An optimized Western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein

The Journal of biological chemistry, 2023-02, Vol.299 (2), p.102823-102823, Article 102823

2023

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Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

Nature (London), 2011-02, Vol.470 (7335), p.540-542

2011

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The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

The Journal of neuroscience, 2012-11, Vol.32 (47), p.16857

2012

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Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked

Nature communications, 2014-07, Vol.5 (1), p.4347, Article 4347

2014

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Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers: ROLE OF N-TERMINAL RESIDUES

The Journal of biological chemistry, 2010-08, Vol.285 (34), p.26377-26383

2010

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Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

The Journal of biological chemistry, 2016-02, Vol.291 (7), p.3174-3183

2016

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Prions, prionoids and protein misfolding disorders

Nature reviews. Genetics, 2018-07, Vol.19 (7), p.405

2018

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General Model of Prion Strains and Their Pathogenicity

Science (American Association for the Advancement of Science), 2007-11, Vol.318 (5852), p.930-936

2007

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Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)

The Journal of biological chemistry, 2014-10, Vol.289 (41), p.28460-28477

2014

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The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

The EMBO journal, 2011-05, Vol.30 (10), p.2057-2070

2011

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Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

The Journal of biological chemistry, 2015-07, Vol.290 (28), p.17415-17438

2015

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The prion protein as a receptor for amyloid-beta

Nature (London), 2010-08, Vol.466 (7308), p.E3-E4

2010

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The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

Nature (London), 2013-09, Vol.501 (7465), p.102-106

2013

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The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils

Viruses, 2021-08, Vol.13 (8), p.1625

2021

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The prion protein and its ligands: Insights into structure-function relationships

Biochimica et biophysica acta. Molecular cell research, 2022-06, Vol.1869 (6), p.119240-119240, Article 119240

2022

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Divergent prion strain evolution driven by PrP C expression level in transgenic mice

Nature communications, 2017-01, Vol.8, p.14170

2017

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A New Paradigm for Enzymatic Control of α-Cleavage and β-Cleavage of the Prion Protein

The Journal of biological chemistry, 2014-01, Vol.289 (2), p.803-813

2014

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

Nature neuroscience, 2012-09, Vol.15 (9), p.1227-1235

2012

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Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion

Journal of virology, 2015-09, Vol.89 (18), p.9524-9531

2015

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Prion protein β 2- α 2 loop conformational landscape

Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (36), p.9617-9622

2017

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High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease

Brain (London, England : 1878), 2014-03, Vol.137 (Pt 3), p.873-886

2014

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Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP

PLoS pathogens, 2010-07, Vol.6 (7), p.e1000977-e1000977

2010

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α2,3 linkage of sialic acid to a GPI anchor and an unpredicted GPI attachment site in human prion protein

The Journal of biological chemistry, 2020-05, Vol.295 (22), p.7789-7798

2020

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Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains

Journal of virology, 2015-12, Vol.89 (24), p.12362-12373

2015

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Cryo-EM structure of an amyloid fibril formed by full-length human prion protein

An optimized Western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked

Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers: ROLE OF N-TERMINAL RESIDUES

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

Prions, prionoids and protein misfolding disorders

General Model of Prion Strains and Their Pathogenicity

Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

The prion protein as a receptor for amyloid-beta

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils

The prion protein and its ligands: Insights into structure-function relationships

Divergent prion strain evolution driven by PrP C expression level in transgenic mice

A New Paradigm for Enzymatic Control of α-Cleavage and β-Cleavage of the Prion Protein

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion

Prion protein β 2- α 2 loop conformational landscape

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease

Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP

α2,3 linkage of sialic acid to a GPI anchor and an unpredicted GPI attachment site in human prion protein

Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains

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