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Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes

EMBO reports, 2021-04, Vol.22 (4), p.e51023-n/a

2021

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TUBA1A licenses APC/C‐mediated mitotic progression to drive glioblastoma growth by inhibiting PLK3

FEBS letters, 2023-12, Vol.597 (24), p.3072-3086

2023

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Polo‐Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

The oncologist (Dayton, Ohio), 2009-06, Vol.14 (6), p.559-570

Schöffski, Patrick

2009

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Therapeutic potential of targeting polo-like kinase 4

European journal of medicinal chemistry, 2024-02, Vol.265, p.116115-116115, Article 116115

2024

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Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop

The EMBO journal, 2021-09, Vol.40 (18), p.e107516-n/a

2021

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Kinases Involved in Both Autophagy and Mitosis

International journal of molecular sciences, 2017-08, Vol.18 (9), p.1884

2017

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RNAi prodrugs decrease elevated mRNA levels of Polo‐like kinase 1 in ex vivo cultured primary cells from pediatric acute myeloid leukemia patients

The FASEB journal, 2021-05, Vol.35 (5), p.e21476-n/a

2021

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The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?

Genes, 2019-03, Vol.10 (3), p.208

de Cárcer, Guillermo

2019

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Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate

The EMBO journal, 2007-05, Vol.26 (9), p.2262-2273

2007

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Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model

International journal of molecular sciences, 2021-04, Vol.22 (8), p.3865

2021

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Potential Tumor Suppressor Role of Polo-like Kinase 5 in Cancer

Cancers, 2023-11, Vol.15 (22), p.5457

2023

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Tazarotene‐induced gene 1 interacts with Polo‐like kinase 2 and inhibits cell proliferation in HCT116 colorectal cancer cells

Cell biology international, 2021-11, Vol.45 (11), p.2347-2356

2021

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The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma

Diagnostic pathology, 2023-11, Vol.18 (1), p.129-129, Article 129

2023

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Inhibition of polo-like kinase 1 suppresses microtubule dynamics in MCF-7 cells

Molecular and cellular biochemistry, 2020-02, Vol.465 (1-2), p.27-36

2020

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Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification

Angewandte Chemie (International ed.), 2011-09, Vol.50 (40), p.9378-9381

2011

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The TSC1‐mTOR‐PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage‐specific manner

Glia, 2018-09, Vol.66 (9), p.1947-1959

2018

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Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma

Cancer letters, 2017-05, Vol.394, p.13-21

2017

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Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis

Molecular oncology, 2014-05, Vol.8 (3), p.596-608

2014

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Performance of a PLK1‐based immune risk model for prognosis and treatment response prediction in breast cancer

Cancer medicine (Malden, MA), 2023-05, Vol.12 (9), p.11020-11039

2023

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FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage

Journal of cellular biochemistry, 2017-11, Vol.118 (11), p.3968-3975

2017

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Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide

Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (19), p.4903-4908

2018

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Drugs by Numbers: Reaction-Driven De Novo Design of Potent and Selective Anticancer Leads

Angewandte Chemie (International ed.), 2013-04, Vol.52 (17), p.4676-4681

International ed. in English, 2013

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Playing polo during mitosis: PLK1 takes the lead

Oncogene, 2017-08, Vol.36 (34), p.4819-4827

2017

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Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma

Cancer gene therapy, 2013-09, Vol.20 (9), p.499-506

2013

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Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades

The Prostate, 2004-08, Vol.60 (3), p.240-245

2004

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Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes

TUBA1A licenses APC/C‐mediated mitotic progression to drive glioblastoma growth by inhibiting PLK3

Polo‐Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

Therapeutic potential of targeting polo-like kinase 4

Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop

Kinases Involved in Both Autophagy and Mitosis

RNAi prodrugs decrease elevated mRNA levels of Polo‐like kinase 1 in ex vivo cultured primary cells from pediatric acute myeloid leukemia patients

The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?

Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate

Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model

Potential Tumor Suppressor Role of Polo-like Kinase 5 in Cancer

Tazarotene‐induced gene 1 interacts with Polo‐like kinase 2 and inhibits cell proliferation in HCT116 colorectal cancer cells

The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma

Inhibition of polo-like kinase 1 suppresses microtubule dynamics in MCF-7 cells

Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification

The TSC1‐mTOR‐PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage‐specific manner

Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma

Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis

Performance of a PLK1‐based immune risk model for prognosis and treatment response prediction in breast cancer

FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage

Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide

Drugs by Numbers: Reaction-Driven De Novo Design of Potent and Selective Anticancer Leads

Playing polo during mitosis: PLK1 takes the lead

Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma

Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades

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