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Towards optimizing cefepime/tazobactam (WCK 4282) exposure to achieve efficacy against piperacillin/tazobactam-resistant ESBL infections: dose recommendations for various renal functions, including intermittent haemodialysis, in healthy individuals

Journal of antimicrobial chemotherapy, 2024-05, Vol.79 (5), p.1093-1100

2024

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Balancing the scales: achieving the optimal beta-lactam to beta-lactamase inhibitor ratio with continuous infusion piperacillin/tazobactam against extended spectrum beta-lactamase producing Enterobacterales

Antimicrobial agents and chemotherapy, 2024-04, Vol.68 (4), p.e0140423

2024

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Effect of albumin substitution on pharmacokinetics of piperacillin/tazobactam in patients with severe burn injury admitted to the ICU

Journal of antimicrobial chemotherapy, 2024-02, Vol.79 (2), p.262-270

2024

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Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation

Journal of antimicrobial chemotherapy, 2022-04, Vol.77 (5), p.1353-1364

2022

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Piperacillin-tazobactam dosing in anuric acute kidney injury patients receiving continuous renal replacement therapy

Seminars in dialysis, 2023-11, Vol.36 (6), p.468-476

2023

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Population pharmacokinetics and pharmacodynamics of piperacillin in critically ill patients during the early phase of sepsis

Journal of pharmacokinetics and pharmacodynamics, 2019-06, Vol.46 (3), p.251-261

2019

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Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams

Critical care (London, England), 2011-01, Vol.15 (5), p.R206-R206

2011

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Nonlinear pharmacokinetics of piperacillin in healthy volunteers – implications for optimal dosage regimens

British journal of clinical pharmacology, 2010-11, Vol.70 (5), p.682-693

2010

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Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial

Intensive care medicine, 2014-03, Vol.40 (3), p.380-387

2014

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Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study

Critical care medicine, 2012-05, Vol.40 (5), p.1523-1528

2012

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Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort

Journal of antimicrobial chemotherapy, 2016-01, Vol.71 (1), p.196-207

2016

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Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?

Critical care (London, England), 2013-05, Vol.17 (3), p.R84-R84

2013

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Population Pharmacokinetics of Piperacillin in Nonobese, Obese, and Morbidly Obese Critically Ill Patients

Antimicrobial agents and chemotherapy, 2017-03, Vol.61 (3)

2017

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Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy

Antimicrobial agents and chemotherapy, 2022-12, Vol.66 (12), p.e0113522

2022

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Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy

Critical care (London, England), 2011-01, Vol.15 (3), p.R137-R137

2011

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Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients

International journal of antimicrobial agents, 2018-04, Vol.51 (4), p.594-600

2018

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Population Pharmacokinetics of Piperacillin/Tazobactam Across the Adult Lifespan

Clinical pharmacokinetics, 2023, Vol.62 (1), p.127-139

2023

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Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?

Critical care (London, England), 2015-01, Vol.19 (1), p.28-28, Article 28

2015

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The Impact of Variation in Renal Replacement Therapy Settings on Piperacillin, Meropenem, and Vancomycin Drug Clearance in the Critically Ill: An Analysis of Published Literature and Dosing Regimens

Critical care medicine, 2014-07, Vol.42 (7), p.1640-1650

2014

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Case-Control Study of Drug Monitoring of β-Lactams in Obese Critically Ill Patients

Antimicrobial Agents and Chemotherapy, 2013-02, Vol.57 (2), p.708-715

2013

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Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy

Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.4094-4102

2014

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Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β‐Lactam Antibiotics in Critically Ill Children

Journal of clinical pharmacology, 2021-04, Vol.61 (4), p.565-573

2021

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Comparison of piperacillin exposure in the lungs of critically ill patients and healthy volunteers

Journal of antimicrobial chemotherapy, 2018-05, Vol.73 (5), p.1340-1347

2018

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β-Lactam pharmacokinetics during extracorporeal membrane oxygenation therapy: A case–control study

International journal of antimicrobial agents, 2015-03, Vol.45 (3), p.278-282

2015

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Therapeutic drug monitoring of piperacillin and tazobactam by RP-HPLC of residual blood specimens

Clinica chimica acta, 2018-07, Vol.482, p.60-64

2018

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Towards optimizing cefepime/tazobactam (WCK 4282) exposure to achieve efficacy against piperacillin/tazobactam-resistant ESBL infections: dose recommendations for various renal functions, including intermittent haemodialysis, in healthy individuals

Balancing the scales: achieving the optimal beta-lactam to beta-lactamase inhibitor ratio with continuous infusion piperacillin/tazobactam against extended spectrum beta-lactamase producing Enterobacterales

Effect of albumin substitution on pharmacokinetics of piperacillin/tazobactam in patients with severe burn injury admitted to the ICU

Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation

Piperacillin-tazobactam dosing in anuric acute kidney injury patients receiving continuous renal replacement therapy

Population pharmacokinetics and pharmacodynamics of piperacillin in critically ill patients during the early phase of sepsis

Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams

Nonlinear pharmacokinetics of piperacillin in healthy volunteers – implications for optimal dosage regimens

Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial

Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort

Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?

Population Pharmacokinetics of Piperacillin in Nonobese, Obese, and Morbidly Obese Critically Ill Patients

Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy

Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy

Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients

Population Pharmacokinetics of Piperacillin/Tazobactam Across the Adult Lifespan

Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?

The Impact of Variation in Renal Replacement Therapy Settings on Piperacillin, Meropenem, and Vancomycin Drug Clearance in the Critically Ill: An Analysis of Published Literature and Dosing Regimens

Case-Control Study of Drug Monitoring of β-Lactams in Obese Critically Ill Patients

Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy

Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β‐Lactam Antibiotics in Critically Ill Children

Comparison of piperacillin exposure in the lungs of critically ill patients and healthy volunteers

β-Lactam pharmacokinetics during extracorporeal membrane oxygenation therapy: A case–control study

Therapeutic drug monitoring of piperacillin and tazobactam by RP-HPLC of residual blood specimens

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