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PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models

The Journal of clinical investigation, 2016-09, Vol.126 (9), p.3613-3625

2016

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Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells

Journal of the American Society of Nephrology, 2016-09, Vol.27 (9), p.2702-2719

2016

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The Phosphatidylinositol 3‐kinase Class III Complex Containing TcVps15 and TcVps34 Participates in Autophagy in Trypanosoma cruzi

The Journal of eukaryotic microbiology, 2017-05, Vol.64 (3), p.308-321

2017

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Autophagy genes coordinate with the class II PI/PtdIns 3-kinase PIKI-1 to regulate apoptotic cell clearance in C. elegans

Autophagy, 2013-12, Vol.9 (12), p.2022-2032

2013

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The relation between PI3K/AKT signalling pathway and cancer

Gene, 2019-05, Vol.698, p.120-128

2019

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PI3K/AKT signaling pathway and cancer: an updated review

Annals of medicine (Helsinki), 2014-09, Vol.46 (6), p.372-383

2014

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PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting

Nature reviews. Cancer, 2015-01, Vol.15 (1), p.7-24

2015

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Classes of phosphoinositide 3-kinases at a glance

Journal of cell science, 2014-03, Vol.127 (Pt 5), p.923-928

2014

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Role of PI3K/AKT pathway in cancer: the framework of malignant behavior

Molecular biology reports, 2020-06, Vol.47 (6), p.4587-4629

2020

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Nature reviews. Genetics, 2006-08, Vol.7 (8), p.606-619

2006

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Molecular Alterations and Everolimus Efficacy in Human Epidermal Growth Factor Receptor 2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Biomarker Analysis From BOLERO-1 and BOLERO-3

Journal of clinical oncology, 2016-06, Vol.34 (18), p.2115-2124

2016

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Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

Annual review of immunology, 2013-01, Vol.31 (1), p.675-704

Okkenhaug, Klaus

2013

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Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt

Molecular cell, 2018-09, Vol.71 (6), p.1092-1104.e5

2018

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Development of PI3K inhibitors: lessons learned from early clinical trials

Nature reviews. Clinical oncology, 2013-03, Vol.10 (3), p.143-153

2013

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Regulation of mTORC1 by PI3K signaling

Trends in cell biology, 2015-09, Vol.25 (9), p.545-555

2015

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Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

The Journal of immunology (1950), 2017-02, Vol.198 (3), p.1006-1014

2017

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The PI3K/AKT/mTOR interactive pathway

Molecular bioSystems, 2015-07, Vol.11 (7), p.1946-1954

2015

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Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood

Human reproduction update, 2015-11, Vol.21 (6), p.779-786

2015

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AKT in cancer: new molecular insights and advances in drug development

British journal of clinical pharmacology, 2016-10, Vol.82 (4), p.943-956

2016

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GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway

Molecular cancer therapeutics, 2011-12, Vol.10 (12), p.2426-2436

2011

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A human immunodeficiency caused by mutations in the PIK3R1 gene

The Journal of clinical investigation, 2014-09, Vol.124 (9), p.3923-3928

2014

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PI3K pathway alterations in cancer: variations on a theme

Oncogene, 2008-09, Vol.27 (41), p.5497-5510

2008

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Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1

Cancer research (Chicago, Ill.), 2009-06, Vol.69 (11), p.4885-4893

2009

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Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma

The Journal of clinical investigation, 2021-11, Vol.131 (22), p.1-15

2021

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PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models

Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells

The Phosphatidylinositol 3‐kinase Class III Complex Containing TcVps15 and TcVps34 Participates in Autophagy in Trypanosoma cruzi

Autophagy genes coordinate with the class II PI/PtdIns 3-kinase PIKI-1 to regulate apoptotic cell clearance in C. elegans

The relation between PI3K/AKT signalling pathway and cancer

PI3K/AKT signaling pathway and cancer: an updated review

PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting

Classes of phosphoinositide 3-kinases at a glance

Role of PI3K/AKT pathway in cancer: the framework of malignant behavior

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Molecular Alterations and Everolimus Efficacy in Human Epidermal Growth Factor Receptor 2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Biomarker Analysis From BOLERO-1 and BOLERO-3

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt

Development of PI3K inhibitors: lessons learned from early clinical trials

Regulation of mTORC1 by PI3K signaling

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

The PI3K/AKT/mTOR interactive pathway

Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

AKT in cancer: new molecular insights and advances in drug development

GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway

A human immunodeficiency caused by mutations in the PIK3R1 gene

PI3K pathway alterations in cancer: variations on a theme

Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1

Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma

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