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Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

Journal of molecular biology, 2020-11, Vol.432 (22), p.5849-5859

2020

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Mechanisms of Autophagy Initiation

Annual review of biochemistry, 2017-06, Vol.86 (1), p.225-244

2017

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A Real-Time Phosphatidylinositol 4-Phosphate 5-Kinase Assay Using Fluorescence Spectroscopy

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2251, p.121

Nishimura, Taki

2021

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Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase

Protein expression and purification, 2025-01, Vol.225, p.106582, Article 106582

2025

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Simultaneous Detection of Phosphoinositide Lipids by Radioactive Metabolic Labeling

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2251, p.1

2021

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Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

Journal of molecular biology, 2021-04, Vol.433 (8), p.166838-166838, Article 166838

2021

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Conformational sampling of membranes by Akt controls its activation and inactivation

Proceedings of the National Academy of Sciences - PNAS, 2018-04, Vol.115 (17), p.E3940-E3949

2018

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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6466), p.714-723

2019

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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Biochemical journal, 2014-11, Vol.463 (3), p.413-427

2014

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Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

The Journal of biological chemistry, 2011-04, Vol.286 (13), p.10998-11002

2011

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Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation

Molecular cell, 2013-04, Vol.50 (1), p.29-42

2013

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Phosphoinositide conversion in endocytosis and the endolysosomal system

The Journal of biological chemistry, 2018-02, Vol.293 (5), p.1526-1535

2018

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Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

Cell death and differentiation, 2019-03, Vol.26 (4), p.617-629

2019

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Label-Free Quantification of Phosphoinositides in Drosophila by Mass Spectrometry

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2251, p.19

2021

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Dynamic association of the ULK1 complex with omegasomes during autophagy induction

Journal of cell science, 2013-11, Vol.126 (Pt 22), p.5224-5238

2013

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Profiling of Phosphoinositide Molecular Species in Resting or Activated Human or Mouse Platelets by a LC-MS Method

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2251, p.39

2021

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Redundant function of the Arabidopsis phosphatidylinositol 4‐phosphate 5‐kinase genes PIP5K4–6 is essential for pollen germination

The Plant journal : for cell and molecular biology, 2024-01, Vol.117 (1), p.212-225

2024

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Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas

The Journal of biological chemistry, 2017-07, Vol.292 (29), p.12256-12266

2017

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Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition

The Journal of biological chemistry, 2017-08, Vol.292 (33), p.13541-13550

2017

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Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic

Nature (London), 2017-12, Vol.552 (7685), p.410-414

2017

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PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition

Proceedings of the National Academy of Sciences - PNAS, 2020-09, Vol.117 (39), p.24427-24433

2020

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Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt

Molecular cell, 2018-09, Vol.71 (6), p.1092-1104.e5

2018

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CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors

Cancer cell, 2014-07, Vol.26 (1), p.136-149

2014

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Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation

The Journal of cell biology, 2011-06, Vol.193 (7), p.1275-1288

2011

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Pharmacological and Genetic Targeting of the PI4KA Enzyme Reveals Its Important Role in Maintaining Plasma Membrane Phosphatidylinositol 4-Phosphate and Phosphatidylinositol 4,5-Bisphosphate Levels

The Journal of biological chemistry, 2014-02, Vol.289 (9), p.6120-6132

2014

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Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

Mechanisms of Autophagy Initiation

A Real-Time Phosphatidylinositol 4-Phosphate 5-Kinase Assay Using Fluorescence Spectroscopy

Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase

Simultaneous Detection of Phosphoinositide Lipids by Radioactive Metabolic Labeling

Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

Conformational sampling of membranes by Akt controls its activation and inactivation

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation

Phosphoinositide conversion in endocytosis and the endolysosomal system

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

Label-Free Quantification of Phosphoinositides in Drosophila by Mass Spectrometry

Dynamic association of the ULK1 complex with omegasomes during autophagy induction

Profiling of Phosphoinositide Molecular Species in Resting or Activated Human or Mouse Platelets by a LC-MS Method

Redundant function of the Arabidopsis phosphatidylinositol 4‐phosphate 5‐kinase genes PIP5K4–6 is essential for pollen germination

Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas

Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition

Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic

PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition

Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt

CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors

Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation

Pharmacological and Genetic Targeting of the PI4KA Enzyme Reveals Its Important Role in Maintaining Plasma Membrane Phosphatidylinositol 4-Phosphate and Phosphatidylinositol 4,5-Bisphosphate Levels

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