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PPAR-γ Modulators as Current and Potential Cancer Treatments

Frontiers in oncology, 2021-09, Vol.11, p.737776-737776

2021

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Identification of a novel interplaying loop of PPARγ and respective lncRNAs are involved in colorectal cancer progress

International journal of biological macromolecules, 2022-10, Vol.219, p.779-787

2022

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Structure optimization of a new class of PPARγ antagonists

Bioorganic & medicinal chemistry, 2019-11, Vol.27 (21), p.115082-115082, Article 115082

2019

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Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice

FEBS letters, 2014-06, Vol.588 (14), p.2277-2281

2014

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Decoration of GW9662 scaffold with a fragment-like hit via copper-catalyzed azide-alkyne cycloaddition reaction into peroxisome proliferator-activated receptor γ agonists

Tetrahedron letters, 2024-09, Vol.148, p.155226, Article 155226

2024

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Macrophage M1/M2 polarization

European journal of pharmacology, 2020-06, Vol.877, p.173090-173090, Article 173090

2020

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Micheliolide alleviates hepatic steatosis in db/db mice by inhibiting inflammation and promoting autophagy via PPAR-γ-mediated NF-кB and AMPK/mTOR signaling

International immunopharmacology, 2018-06, Vol.59, p.197-208

2018

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Leukotriene C4 synthase is a novel PPARγ target gene, and leukotriene C4 and D4 activate adipogenesis through cysteinyl LT1 receptors in adipocytes

Biochimica et biophysica acta. Molecular cell research, 2022-03, Vol.1869 (3), p.119203-119203, Article 119203

2022

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Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation

ACS medicinal chemistry letters, 2022-04, Vol.13 (4), p.681-686

2022

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Peroxisome proliferator-activated receptor-γ ameliorates neuronal ferroptosis after traumatic brain injury in mice by inhibiting cyclooxygenase-2

Experimental neurology, 2022-08, Vol.354, p.114100-114100, Article 114100

2022

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The Role of PPARγ Ligands in Breast Cancer: From Basic Research to Clinical Studies

Cancers, 2020-09, Vol.12 (9), p.2623

2020

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Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARγ/PTEN/AKT pathway in differentiated human embryonic stem cells

Food and chemical toxicology, 2019-09, Vol.131, p.110552, Article 110552

2019

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Exploring the mechanism of PPARγ phosphorylation mediated by CDK5

Journal of structural biology, 2019-09, Vol.207 (3), p.317-326

2019

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Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR‐γ2 transcription factor and TGF‐β/BMP signaling pathways

Aging cell, 2004-12, Vol.3 (6), p.379-389

2004

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Potential of Natural Products in the Inhibition of Adipogenesis through Regulation of PPARγ Expression and/or Its Transcriptional Activity

Molecules (Basel, Switzerland), 2016-09, Vol.21 (10), p.1278

2016

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Cinnamon effects on PPARγ and Adiponectin in 3T3‐L1 adipocytes

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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An integrated study of Shenling Baizhu San against hyperuricemia: Efficacy evaluation, core target identification and active component discovery

Journal of ethnopharmacology, 2022-09, Vol.295, p.115450-115450, Article 115450

2022

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A PPAR-Gamma Agonist Rosiglitazone Suppresses Fibrotic Response in Human Pterygium Fibroblasts by Modulating the p38 MAPK Pathway

Investigative ophthalmology & visual science, 2017-10, Vol.58 (12), p.5217

2017

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Rosiglitazone Attenuates Chronic Hypoxia–Induced Pulmonary Hypertension in a Mouse Model

American journal of respiratory cell and molecular biology, 2010-04, Vol.42 (4), p.482-490

2010

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The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity

Gene, 2018-04, Vol.649, p.14-22

2018

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CXCR4 influences PUFA desaturation and oxidative stress injury in experimental prostatitis mice by activating Fads2 via PPARγ

Free radical biology & medicine, 2024-10, Vol.223, p.237-249

2024

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N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation

Cellular signalling, 2020-05, Vol.69, p.109553-109553, Article 109553

2020

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Synthesis, docking, in vitro and in vivo antidiabetic activity of pyrazole‐based 2,4‐thiazolidinedione derivatives as PPAR‐γ modulators

Archiv der Pharmazie (Weinheim), 2018-04, Vol.351 (3-4), p.n/a

2018

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Abstract 1506 The Glucocorticoid Receptor β (GRβ) induces glucocorticoid resistance and PPARγ activation to increase eicosanoid and monoacylglyceride synthesis which leads to hepatic lipid accumulation

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106444, Article 106444

2024

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PPARγ/NF-κB axis contributes to cold-induced resolution of experimental colitis and preservation of intestinal barrier

Biochimica et biophysica acta. Molecular basis of disease, 2024-10, Vol.1870 (7), p.167326, Article 167326

2024

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