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Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors

European journal of medicinal chemistry, 2019-04, Vol.168, p.87-109

2019

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Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors

Bioorganic chemistry, 2022-02, Vol.119, p.105564-105564, Article 105564

2022

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Synthesis of new pyridothienopyrimidinone and pyridothienotriazolopyrimidine derivatives as pim-1 inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.58-66

2018

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Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1679-1683

2007

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Synthesis of new pyridothienopyrimidinone derivatives as Pim-1 inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.457-467

2017

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Synthesis and biological evaluation of quinoline derivatives as potential anti-prostate cancer agents and Pim-1 kinase inhibitors

Bioorganic & medicinal chemistry, 2016-04, Vol.24 (8), p.1889-1897

2016

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Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase

European journal of medicinal chemistry, 2023-01, Vol.245, p.114914-114914, Article 114914

2023

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Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (4), p.1224-1228

2016

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Structural insights for rational design of new PIM-1 kinase inhibitors based on 3,5-disubstituted indole derivatives: An integrative computational approach

Computers in biology and medicine, 2020-03, Vol.118, p.103641-103641, Article 103641

2020

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Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (11), p.3019-3022

2009

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Inhibition of Pim-1 Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice

Digestive diseases and sciences, 2012-07, Vol.57 (7), p.1822-1831

2012

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Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study

Bioorganic chemistry, 2024-02, Vol.143, p.106988-106988, Article 106988

2024

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Discovery and identification of PIM-1 kinase inhibitors through a hybrid screening approach

Molecular diversity, 2014-05, Vol.18 (2), p.335-344

2014

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Synthesis, cytotoxicity, in-vitro antibacterial screening and in-silico study of novel thieno[2,3-b]pyridines as potential pim-1 inhibitors

Synthetic communications, 2020-08, Vol.50 (15), p.2376-2389

2020

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Assessment of structural and activity-related contributions of various PIM-1 kinase inhibitors in the treatment of leukemia and prostate cancer

Molecular diversity, 2024-04

2024

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A PIM-1 Kinase Inhibitor Docking Optimization Study Based on Logistic Regression Models and Interaction Analysis

Life (Basel, Switzerland), 2023-07, Vol.13 (8), p.1635

2023

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Pim-1 inhibitor attenuates trinitrobenzene sulphonic acid induced colitis in the mice

Clinics and research in hepatology and gastroenterology, 2018-09, Vol.42 (4), p.382-386

2018

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Isoxazolo[3,4- b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (19), p.5206-5208

2008

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Indole: A privileged scaffold for the design of anti-cancer agents

European journal of medicinal chemistry, 2019-12, Vol.183, p.111691-111691, Article 111691

2019

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Discovery of PIM-1 kinase inhibitors based on the 2,5-disubstituted 1,3,4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo cytotoxicity investigation

European journal of medicinal chemistry, 2023-03, Vol.250, p.115220-115220, Article 115220

2023

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Imparting aromaticity to 2-pyridone derivatives by O -alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis

Journal of enzyme inhibition and medicinal chemistry, 2024-12, Vol.39 (1), p.2304044-2304044

2024

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Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities

Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2152810-2152810

2023

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Design, synthesis and docking study of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors

Bioorganic chemistry, 2018-10, Vol.80, p.674-692

2018

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Synthesis and Biological Evaluation of Pyrazolo[1,5‑a]pyrimidine Compounds as Potent and Selective Pim‑1 Inhibitors

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.63-67

2015

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