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Are Pax proteins potential therapeutic targets in kidney disease and cancer?

Kidney international, 2018-08, Vol.94 (2), p.259-267

2018

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Genetic Variability of the Paired Box Transcription Factor; PAX8 Gene: Guidance Towards Treatment Strategies in a Cohort of Congenital Hypothyroidism

Hormone and metabolic research, 2021-05, Vol.53 (5), p.311-318

2021

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PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome

Neoplasia (New York, N.Y.), 2023-02, Vol.36, p.100866-100866, Article 100866

2023

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The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17

Science signaling, 2022-04, Vol.15 (728), p.eabm2496

2022

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Silencing of long noncoding RNA LINC00958 prevents tumor initiation of pancreatic cancer by acting as a sponge of microRNA-330-5p to down-regulate PAX8

Cancer letters, 2019-04, Vol.446, p.49-61

2019

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Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube

Cell reports (Cambridge), 2021-04, Vol.35 (2), p.108978-108978, Article 108978

2021

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The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer

Nature (London), 2022-06, Vol.606 (7916), p.999-1006

2022

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SOX17 and PAX8 constitute an actionable lineage-survival transcriptional complex in ovarian cancer

Oncogene, 2022-03, Vol.41 (12), p.1767-1779

2022

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Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling

Proceedings of the National Academy of Sciences - PNAS, 2024-08, Vol.121 (34), p.e2402998121

2024

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Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation

Cell death and differentiation, 2016-08, Vol.23 (8), p.1347-1357

2016

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Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease

Kidney international, 2024-02, Vol.105 (2), p.312-327

2024

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PAX8 expression in anaplastic thyroid carcinoma is less than those reported in early studies: a multi-institutional study of 182 cases using the monoclonal antibody MRQ-50

Virchows Archiv : an international journal of pathology, 2020-03, Vol.476 (3), p.431-437

2020

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Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney

Journal of the American Society of Nephrology, 2020-06, Vol.31 (6), p.1212-1225

2020

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Immunohistochemical expression of PAX8, PAX2, and cytokeratin in melanomas

Journal of cutaneous pathology, 2021-10, Vol.48 (10), p.1246-1251

2021

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Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors

Scientific reports, 2022-02, Vol.12 (1), p.2144-2144, Article 2144

2022

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Immunophenotypic features of dedifferentiated endometrial carcinoma - insights from BRG1/INI1-deficient tumours

Histopathology, 2016-10, Vol.69 (4), p.560-569

2016

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Multi-genomic analysis of 260 adrenocortical cancer patient tumors identifies novel network BIRC5-hsa-miR-335-5p-PAX8-AS1 strongly associated with poor survival

Surgery, 2023-01, Vol.173 (1), p.43-51

2023

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Premature Classification of Early-stage Endometrioid Ovarian Carcinoma With Mesonephric-like Differentiation as Mesonephric-like Adenocarcinoma

International journal of gynecological pathology, 2024-07, Vol.43 (4), p.362-372

2024

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Pax‐8: Molecular biology, pathophysiology, and potential pathogenesis

BioFactors (Oxford), 2024-05, Vol.50 (3), p.408-421

2024

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PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation

Cell reports (Cambridge), 2021-09, Vol.36 (12), p.109747-109747, Article 109747

2021

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Targeting PAX8 sensitizes ovarian cancer cells to ferroptosis by inhibiting glutathione synthesis

Apoptosis (London), 2024-10, Vol.29 (9-10), p.1499-1514

2024

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Proteomic analysis reveals a role for PAX8 in peritoneal colonization of high grade serous ovarian cancer that can be targeted with micelle encapsulated thiostrepton

Oncogene, 2019-08, Vol.38 (32), p.6003-6016

2019

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In Silico Search for Drug Candidates Targeting the PAX8-PPARγ Fusion Protein in Thyroid Cancer

International journal of molecular sciences, 2024-05, Vol.25 (10), p.5347

2024

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Ovarian Endometrioid Adenocarcinomas With Infiltrative "Adenofibroma-like" Morphology and Aberrant ß-catenin Expression: Tumors That Coexpress CDX2 and LEF1 With Frequent Neuroendocrine Marker Expression, Diminished/Lost PAX8 and Possible Association With Endometrioid Type II Stem Cell Outgrowths in the Fallopian Tube

International journal of gynecological pathology, 2024-03, Vol.43 (2), p.145-148

2024

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Are Pax proteins potential therapeutic targets in kidney disease and cancer?

Genetic Variability of the Paired Box Transcription Factor; PAX8 Gene: Guidance Towards Treatment Strategies in a Cohort of Congenital Hypothyroidism

PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome

The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17

Silencing of long noncoding RNA LINC00958 prevents tumor initiation of pancreatic cancer by acting as a sponge of microRNA-330-5p to down-regulate PAX8

Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube

The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer

SOX17 and PAX8 constitute an actionable lineage-survival transcriptional complex in ovarian cancer

Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling

PAX8 and MECOM are interaction partners driving ovarian cancer

Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation

Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease

PAX8 expression in anaplastic thyroid carcinoma is less than those reported in early studies: a multi-institutional study of 182 cases using the monoclonal antibody MRQ-50

Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney

Immunohistochemical expression of PAX8, PAX2, and cytokeratin in melanomas

Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors

Immunophenotypic features of dedifferentiated endometrial carcinoma - insights from BRG1/INI1-deficient tumours

Multi-genomic analysis of 260 adrenocortical cancer patient tumors identifies novel network BIRC5-hsa-miR-335-5p-PAX8-AS1 strongly associated with poor survival

Premature Classification of Early-stage Endometrioid Ovarian Carcinoma With Mesonephric-like Differentiation as Mesonephric-like Adenocarcinoma

Pax‐8: Molecular biology, pathophysiology, and potential pathogenesis

PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation

Targeting PAX8 sensitizes ovarian cancer cells to ferroptosis by inhibiting glutathione synthesis

Proteomic analysis reveals a role for PAX8 in peritoneal colonization of high grade serous ovarian cancer that can be targeted with micelle encapsulated thiostrepton

In Silico Search for Drug Candidates Targeting the PAX8-PPARγ Fusion Protein in Thyroid Cancer

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