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The complex universe of inactive PARP1

Trends in genetics, 2024-09

2024

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A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells

Cell reports (Cambridge), 2024-05, Vol.43 (5), p.114234, Article 114234

2024

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Mechanisms of PARP inhibitor sensitivity and resistance

DNA repair, 2018-11, Vol.71, p.172-176

D’Andrea, Alan D.

2018

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Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1

The Science of the total environment, 2020-08, Vol.728, p.138832-138832, Article 138832

2020

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NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis

Neuron (Cambridge, Mass.), 2023-11, Vol.111 (22), p.3634-3649.e7

2023

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Increased PARP1‐DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1‐DNA trapping is correlated with PARP1 inhibitor's cytotoxicity

International journal of cancer, 2019-08, Vol.145 (3), p.714-727

2019

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Decrotonylation of cGAS K254 prompts homologous recombination repair by blocking its DNA binding and releasing PARP1

The Journal of biological chemistry, 2024-08, Vol.300 (8), p.107554, Article 107554

2024

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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Cell metabolism, 2018-03, Vol.27 (3), p.529-547

2018

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The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy–Current progress and future direction

European journal of medicinal chemistry, 2020-10, Vol.203, p.112570-112570, Article 112570

2020

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The taming of PARP1 and its impact on NAD+ metabolism

Molecular metabolism (Germany), 2020-08, Vol.38, p.100950-100950, Article 100950

2020

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Effect of postharvest nicotinamide treatment on NAD+ metabolism and redox status in strawberry fruit during storage

Phytochemistry (Oxford), 2023-09, Vol.213, p.113766-113766, Article 113766

2023

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Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway

Toxicon (Oxford), 2024-02, Vol.239, p.107612-107612, Article 107612

2024

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ATR prevents Ca2+ overload‐induced necrotic cell death through phosphorylation‐mediated inactivation of PARP1 without DNA damage signaling

The FASEB journal, 2021-05, Vol.35 (5), p.e21373-n/a

2021

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cMET inhibition potentiates the tumor‐selective damaging effects of NQO1‐bioactivatable agents by compromising DNA repair

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Targeting of CD38 and other NAD-dependent Enzymes in Leukemia Patients

Journal of Biomedicine and Biochemistry, 2023-06, Vol.2 (2), p.26-33

2023

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Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy

Pharmacological research, 2022-12, Vol.186, p.106529, Article 106529

2022

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PARP1 inhibition prevents oxidative stress in age-related hearing loss via PAR-Ca2+-AIF axis in cochlear strial marginal cells

Free radical biology & medicine, 2024-08, Vol.220, p.222-235

2024

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An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation

Cell, 2020-11, Vol.183 (4), p.1086-1102.e23

2020

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The Rate of NAD+ Breakdown Is Maintained Constant against Deletion or Overexpression of NAD+-Degrading Enzymes in Mammalian Cells

Journal of Nutritional Science and Vitaminology, 2024/08/31, Vol.70(4), pp.295-304

2024

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Parthanatos and its associated components: Promising therapeutic targets for cancer

Pharmacological research, 2021-01, Vol.163, p.105299-105299, Article 105299

2021

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UHRF2 promotes the malignancy of hepatocellular carcinoma by PARP1 mediated autophagy

Cellular signalling, 2023-09, Vol.109, p.110782-110782, Article 110782

2023

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PARP1: Structural insights and pharmacological targets for inhibition

DNA repair, 2021-07, Vol.103, p.103125-103125, Article 103125

2021

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PARP1 interacts with WDR5 to enhance target gene recognition and facilitate tumorigenesis

Cancer letters, 2024-07, Vol.593, p.216952, Article 216952

2024

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Mechanism Analysis of Artemisinin and Artesunate as Lung Cancer Therapy Agents Through in Silico Method

OnLine Journal of Biological Sciences, 2024-03, Vol.24 (3), p.336-348

2024

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PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage

Biochemical and biophysical research communications, 2023-02, Vol.646, p.78-85

2023

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The complex universe of inactive PARP1

A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells

Mechanisms of PARP inhibitor sensitivity and resistance

Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1

NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis

Increased PARP1‐DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1‐DNA trapping is correlated with PARP1 inhibitor's cytotoxicity

Decrotonylation of cGAS K254 prompts homologous recombination repair by blocking its DNA binding and releasing PARP1

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy–Current progress and future direction

The taming of PARP1 and its impact on NAD+ metabolism

Effect of postharvest nicotinamide treatment on NAD+ metabolism and redox status in strawberry fruit during storage

Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway

ATR prevents Ca2+ overload‐induced necrotic cell death through phosphorylation‐mediated inactivation of PARP1 without DNA damage signaling

cMET inhibition potentiates the tumor‐selective damaging effects of NQO1‐bioactivatable agents by compromising DNA repair

Targeting of CD38 and other NAD-dependent Enzymes in Leukemia Patients

Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy

PARP1 inhibition prevents oxidative stress in age-related hearing loss via PAR-Ca2+-AIF axis in cochlear strial marginal cells

An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation

The Rate of NAD+ Breakdown Is Maintained Constant against Deletion or Overexpression of NAD+-Degrading Enzymes in Mammalian Cells

Parthanatos and its associated components: Promising therapeutic targets for cancer

UHRF2 promotes the malignancy of hepatocellular carcinoma by PARP1 mediated autophagy

PARP1: Structural insights and pharmacological targets for inhibition

PARP1 interacts with WDR5 to enhance target gene recognition and facilitate tumorigenesis

Mechanism Analysis of Artemisinin and Artesunate as Lung Cancer Therapy Agents Through in Silico Method

PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage

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