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Furazans in Medicinal Chemistry

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.1786-1815

2021

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Oxadiazoles in Medicinal Chemistry

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1817-1830

2012

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Multistep Synthesis of Analogues of Remdesivir: Incorporating Heterocycles at the C‑1′ Position

Journal of organic chemistry, 2023-07, Vol.88 (13), p.9105-9122

2023

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Synthesis of 1,3,4-oxadiazole derivatives with anticonvulsant activity and their binding to the GABA A receptor

European journal of medicinal chemistry, 2020-11, Vol.206, p.112672

2020

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Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions

The Lancet (British edition), 2021-09, Vol.398 (10306), p.1184-1194

2021

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The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

Journal of molecular biology, 2014-04, Vol.426 (8), p.1848-1860

2014

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Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

Lancet neurology, 2016-02, Vol.15 (2), p.154-165

2016

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New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies

European journal of medicinal chemistry, 2019-12, Vol.183, p.111693, Article 111693

2019

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Ozanimod: First Approval

Drugs (New York, N.Y.), 2020-06, Vol.80 (8), p.841-848

Lamb, Yvette N.

2020

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Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

Nature (London), 2017-03, Vol.543 (7645), p.428-432

2017

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Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review

European journal of medicinal chemistry, 2021-01, Vol.209, p.112886-112886, Article 112886

2021

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Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6612-6630

2022

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Synthesis and Anticancer Activity of New ((Furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole Acyclic Sugar Derivatives

Chemical and Pharmaceutical Bulletin, 2019/08/01, Vol.67(8), pp.888-895

2019

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Design and synthesis of 3-(4-pyridyl)-5-(4-sulfamido-phenyl)-1,2,4-oxadiazole derivatives as novel GSK-3β inhibitors and evaluation of their potential as multifunctional anti-Alzheimer agents

European journal of medicinal chemistry, 2021-01, Vol.209, p.112874, Article 112874

2021

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Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis

European journal of medicinal chemistry, 2016-11, Vol.123, p.523-531

2016

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Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles

European journal of medicinal chemistry, 2018-02, Vol.145, p.1-10

2018

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Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6

Journal of medicinal chemistry, 2023-10, Vol.66 (19), p.13821-13837

2023

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1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities

Bioorganic & medicinal chemistry, 2017-08, Vol.25 (15), p.4064-4075

2017

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Results From the First‐in‐Human Study With Ozanimod, a Novel, Selective Sphingosine‐1‐Phosphate Receptor Modulator

Journal of clinical pharmacology, 2017-08, Vol.57 (8), p.988-996

2017

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Unique Carbazole-Oxadiazole Derivatives as New Potential Antibiotics for Combating Gram-Positive and -Negative Bacteria

Journal of medicinal chemistry, 2022-04, Vol.65 (8), p.6171-6190

2022

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Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial

JAMA neurology, 2015-11, Vol.72 (11), p.1324

2015

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Novel 1,3,4-Oxadiazole-2-carbohydrazides as Prospective Agricultural Antifungal Agents Potentially Targeting Succinate Dehydrogenase

Journal of agricultural and food chemistry, 2019-12, Vol.67 (50), p.13892-13903

2019

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Discovery of 5‑(Piperidin-4-yl)-1,2,4-oxadiazole Derivatives as a New Class of Human Caseinolytic Protease P Agonists for the Treatment of Hepatocellular Carcinoma

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.10622-10642

2024

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1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells

Journal of medicinal chemistry, 2014-07, Vol.57 (14), p.6259-6265

2014

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Furazans in Medicinal Chemistry

Oxadiazoles in Medicinal Chemistry

Multistep Synthesis of Analogues of Remdesivir: Incorporating Heterocycles at the C‑1′ Position

Synthesis of 1,3,4-oxadiazole derivatives with anticonvulsant activity and their binding to the GABA A receptor

Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies

Ozanimod: First Approval

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic

Synthesis and Anticancer Activity of New ((Furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole Acyclic Sugar Derivatives

Design and synthesis of 3-(4-pyridyl)-5-(4-sulfamido-phenyl)-1,2,4-oxadiazole derivatives as novel GSK-3β inhibitors and evaluation of their potential as multifunctional anti-Alzheimer agents

Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis

Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles

Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6

1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities

Results From the First‐in‐Human Study With Ozanimod, a Novel, Selective Sphingosine‐1‐Phosphate Receptor Modulator

Unique Carbazole-Oxadiazole Derivatives as New Potential Antibiotics for Combating Gram-Positive and -Negative Bacteria

Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial

Novel 1,3,4-Oxadiazole-2-carbohydrazides as Prospective Agricultural Antifungal Agents Potentially Targeting Succinate Dehydrogenase

Discovery of 5‑(Piperidin-4-yl)-1,2,4-oxadiazole Derivatives as a New Class of Human Caseinolytic Protease P Agonists for the Treatment of Hepatocellular Carcinoma

1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells

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