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In silico comparative analysis of cestode and human NPC1 provides insights for ezetimibe repurposing to visceral cestodiases treatment

Scientific reports, 2024-09, Vol.14 (1), p.21282-14, Article 21282

2024

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Cholesterol Handling in Lysosomes and Beyond

Trends in cell biology, 2020-06, Vol.30 (6), p.452-466

2020

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Endolysosomal cholesterol export: More than just NPC1

BioEssays, 2022-10, Vol.44 (10), p.e2200111-n/a

Lu, Albert

2022

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Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6331), p.1306-1311

2017

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Saturation variant interpretation using CRISPR prime editing

Nature biotechnology, 2022-06, Vol.40 (6), p.885-895

2022

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NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Nature communications, 2019-09, Vol.10 (1), p.4276-14, Article 4276

2019

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ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C

Nature cell biology, 2019-10, Vol.21 (10), p.1206-1218

2019

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Structural advances in sterol-sensing domain-containing proteins

Trends in biochemical sciences (Amsterdam. Regular ed.), 2022-04, Vol.47 (4), p.289-300

2022

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Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells

Cellular and molecular life sciences : CMLS, 2020-07, Vol.77 (14), p.2839-2857

2020

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Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial

The Lancet (British edition), 2017-10, Vol.390 (10104), p.1758-1768

2017

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Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging

Analytical chemistry (Washington), 2021-03, Vol.93 (11), p.4932-4943

2021

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Npc1 gene mutation abnormally activates the classical Wnt signalling pathway in mouse kidneys and promotes renal fibrosis

Animal genetics, 2024-02, Vol.55 (1), p.99-109

2024

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Structures of human Patched and its complex with native palmitoylated sonic hedgehog

Nature (London), 2018-08, Vol.560 (7716), p.128-132

2018

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Niemann–Pick type C disease: cellular pathology and pharmacotherapy

Journal of neurochemistry, 2020-06, Vol.153 (6), p.674-692

2020

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ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange

The EMBO journal, 2021-07, Vol.40 (14), p.e106871-n/a

2021

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Structural and Energetic Basis for Differential Binding of Ebola and Marburg Virus Glycoproteins to a Bat-Derived Niemann-Pick C1 Protein

The Journal of infectious diseases, 2023-11, Vol.228 (Suppl 7), p.S479-S487

2023

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mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells

Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (30), p.7999-8004

2017

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NPC1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP46A1 activation

EMBO reports, 2019-11, Vol.20 (11), p.e48143-n/a

2019

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Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Nature communications, 2021-02, Vol.12 (1), p.1158-1158, Article 1158

2021

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CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

The Journal of cell biology, 2022-02, Vol.221 (2), p.1

2022

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Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

Nature communications, 2018-09, Vol.9 (1), p.3671-13, Article 3671

2018

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Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry

Nature structural & molecular biology, 2021-02, Vol.28 (2), p.181-189

2021

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Structural basis for itraconazole-mediated NPC1 inhibition

Nature communications, 2020-01, Vol.11 (1), p.152-152, Article 152

2020

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Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

eLife, 2015-12, Vol.4

2015

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In silico comparative analysis of cestode and human NPC1 provides insights for ezetimibe repurposing to visceral cestodiases treatment

Cholesterol Handling in Lysosomes and Beyond

Endolysosomal cholesterol export: More than just NPC1

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

Saturation variant interpretation using CRISPR prime editing

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C

Structural advances in sterol-sensing domain-containing proteins

Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells

Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial

Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging

Npc1 gene mutation abnormally activates the classical Wnt signalling pathway in mouse kidneys and promotes renal fibrosis

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

Niemann–Pick type C disease: cellular pathology and pharmacotherapy

ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange

Structural and Energetic Basis for Differential Binding of Ebola and Marburg Virus Glycoproteins to a Bat-Derived Niemann-Pick C1 Protein

mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells

NPC1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP46A1 activation

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

Structural basis for itraconazole-mediated NPC1 inhibition

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

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