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Impact of body mass index on suppression of follicular development and ovulation using a transdermal patch containing 0.55-mg ethinyl estradiol/2.1-mg gestodene: a multicenter, open-label, uncontrolled study over three treatment cycles

Contraception (Stoneham), 2014-09, Vol.90 (3), p.272-279

2014

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Synchronic release of two hormonal contraceptives for about one month from the PLGA microspheres: In vitro and in vivo studies

Journal of controlled release, 2008-08, Vol.129 (3), p.192-199

2008

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An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch

Drug design, development and therapy, 2017-01, Vol.11, p.725-731

2017

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Preparation and in vitro/in vivo evaluation of gestodene (GEST) intravaginal ring

Pakistan journal of pharmaceutical sciences, 2016-09, Vol.29 (5), p.1545

2016

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Implications of different application sites on the bioavailability of a transdermal contraceptive patch containing ethinyl estradiol and gestodene: an open-label, randomized, crossover study

International journal of clinical pharmacology and therapeutics, 2014-10, Vol.52 (10), p.856-866

2014

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INFLUENCE OF ETHINYLESTRADIOL - GESTODENE COMBINATION ON THE FUNCTIONAL ACTIVITY AND EXPRESSION OF P-GLYCOPROTEIN.

Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ, 2016, Vol.79 (6), p.15

2016

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Double-layer weekly sustained release transdermal patch containing gestodene and ethinylestradiol

International journal of pharmaceutics, 2009-07, Vol.377 (1), p.128-134

2009

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Pharmacokinetic drug–drug interaction between ethinyl estradiol and gestodene, administered as a transdermal fertility control patch, and two CYP3A4 inhibitors and a CYP3A4 substrate

European journal of drug metabolism and pharmacokinetics, 2015-12, Vol.40 (4), p.389-399

2015

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The in vivo human metabolism of tibolone

Drug metabolism and disposition, 2002-02, Vol.30 (2), p.106-112

2002

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Selective tissue distribution of tibolone metabolites in mature ovariectomized female cynomolgus monkeys after multiple doses of tibolone

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1105-1111

2007

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Pharmacokinetics and adhesion of a transdermal patch containing ethinyl estradiol and gestodene under conditions of heat, humidity, and exercise: A single-center, open-label, randomized, crossover study

Clinical pharmacology in drug development, 2015-07, Vol.4 (4), p.245-255

2015

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Pharmacokinetic parameters of tibolone and metabolites in plasma, urine, feces, and bile from ovariectomized cynomolgus monkeys after a single dose or multiple doses of tibolone

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1112-1118

2007

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Development and validation of UPLC-MS/MS method for simultaneous determination of gestodene and ethinyl estradiol in rat plasma

Biomedical chromatography, 2010-02, Vol.24 (2), p.160-168

2010

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Bioequivalence Studies of Tibolone in Premenopausal Women and Effects on Expression of the Tibolone-Metabolizing Enzyme AKR1C (Aldo-Keto Reductase) Family Caused by Estradiol

Journal of clinical pharmacology, 2008-12, Vol.48 (12), p.1430-1437

2008

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Pharmacokinetics of tibolone in early and late postmenopausal women

British journal of clinical pharmacology, 2002-08, Vol.54 (2), p.101-106

2002

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Simultaneous determination of gestodene, etonogestrel and ethinylestradiol in plasma by LC-MS/MS following derivatization

Yao hsüeh hsüeh pao, 2010-01, Vol.45 (1), p.87

2010

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Pharmacokinetic Parameters of Sulfated Tibolone Metabolites in Postmenopausal Women after Single and Multiple Doses of Tibolone

Clinical pharmacology and therapeutics, 2007-04, Vol.81 (4), p.573-579

2007

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Tibolone: a unique version of hormone replacement therapy

The Annals of pharmacotherapy, 2004-05, Vol.38 (5), p.874-881

2004

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Dose Proportionality of Three Different Doses of Tibolone

Pharmacotherapy, 2002-01, Vol.22 (1), p.6-13

2002

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p-Toluenesulfonyl isocyanate as a novel derivatization reagent to enhance the electrospray ionization and its application in the determination of two stereo isomers of 3-hydroxyl-7-methyl-norethynodrel in plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-01, Vol.814 (2), p.331-337

2005

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Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive

Clinical pharmacology and therapeutics, 1995-11, Vol.58 (5), p.523-531

1995

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Stereoselectivity in metabolic 3-reduction of tibolone in healthy Chinese female volunteers

Acta pharmacologica Sinica, 2005-12, Vol.26 (12), p.1527-1530

2005

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In vitro metabolism of gestodene in target organs: formation of A-ring reduced derivatives with oestrogenic activity

European journal of pharmacology, 2001-04, Vol.417 (3), p.249-256

2001

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Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid

Molecular pharmacology, 2004-12, Vol.66 (6), p.1702-1711

2004

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Tibolone

Menopause (New York, N.Y.), 2003-07, Vol.10 (4), p.379-380

Simpson, Evan R.

2003

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Impact of body mass index on suppression of follicular development and ovulation using a transdermal patch containing 0.55-mg ethinyl estradiol/2.1-mg gestodene: a multicenter, open-label, uncontrolled study over three treatment cycles

Synchronic release of two hormonal contraceptives for about one month from the PLGA microspheres: In vitro and in vivo studies

An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch

Preparation and in vitro/in vivo evaluation of gestodene (GEST) intravaginal ring

Implications of different application sites on the bioavailability of a transdermal contraceptive patch containing ethinyl estradiol and gestodene: an open-label, randomized, crossover study

INFLUENCE OF ETHINYLESTRADIOL - GESTODENE COMBINATION ON THE FUNCTIONAL ACTIVITY AND EXPRESSION OF P-GLYCOPROTEIN.

Double-layer weekly sustained release transdermal patch containing gestodene and ethinylestradiol

Pharmacokinetic drug–drug interaction between ethinyl estradiol and gestodene, administered as a transdermal fertility control patch, and two CYP3A4 inhibitors and a CYP3A4 substrate

The in vivo human metabolism of tibolone

Selective tissue distribution of tibolone metabolites in mature ovariectomized female cynomolgus monkeys after multiple doses of tibolone

Pharmacokinetics and adhesion of a transdermal patch containing ethinyl estradiol and gestodene under conditions of heat, humidity, and exercise: A single-center, open-label, randomized, crossover study

Pharmacokinetic parameters of tibolone and metabolites in plasma, urine, feces, and bile from ovariectomized cynomolgus monkeys after a single dose or multiple doses of tibolone

Development and validation of UPLC-MS/MS method for simultaneous determination of gestodene and ethinyl estradiol in rat plasma

Bioequivalence Studies of Tibolone in Premenopausal Women and Effects on Expression of the Tibolone-Metabolizing Enzyme AKR1C (Aldo-Keto Reductase) Family Caused by Estradiol

Pharmacokinetics of tibolone in early and late postmenopausal women

Simultaneous determination of gestodene, etonogestrel and ethinylestradiol in plasma by LC-MS/MS following derivatization

Pharmacokinetic Parameters of Sulfated Tibolone Metabolites in Postmenopausal Women after Single and Multiple Doses of Tibolone

Tibolone: a unique version of hormone replacement therapy

Dose Proportionality of Three Different Doses of Tibolone

p-Toluenesulfonyl isocyanate as a novel derivatization reagent to enhance the electrospray ionization and its application in the determination of two stereo isomers of 3-hydroxyl-7-methyl-norethynodrel in plasma

Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive

Stereoselectivity in metabolic 3-reduction of tibolone in healthy Chinese female volunteers

In vitro metabolism of gestodene in target organs: formation of A-ring reduced derivatives with oestrogenic activity

Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid

Tibolone

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