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An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria

Angewandte Chemie International Edition, 2020-05, Vol.59 (22), p.8512-8516

International ed. in English, 2020

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NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation

Nature methods, 2022-02, Vol.19 (2), p.205-215

2022

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Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2015-09, Vol.59 (9), p.5316-5323

2015

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A Cofactor‐Substrate‐Based Supramolecular Fluorescent Probe for the Ultrafast Detection of Nitroreductase under Hypoxic Conditions

Angewandte Chemie International Edition, 2020-04, Vol.59 (15), p.6021-6027

International ed. in English, 2020

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in vivo imaging and detection of nitroreductase in zebrafish by a new near-infrared fluorescence off–on probe

Biosensors & bioelectronics, 2015-01, Vol.63, p.112-116

2015

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Reduction of polynitroaromatic compounds: the bacterial nitroreductases

FEMS microbiology reviews, 2008-05, Vol.32 (3), p.474-500

2008

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Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy

Cell chemical biology, 2017-03, Vol.24 (3), p.391-403

2017

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Biomimetic sensor based on molecularly imprinted polymer with nitroreductase-like activity for metronidazole detection

Biosensors & bioelectronics, 2016-03, Vol.77, p.393-399

2016

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The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies

International journal of molecular sciences, 2024-04, Vol.25 (8), p.4413

2024

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Revealing Unexplored Sequence-Function Space Using Sequence Similarity Networks

Biochemistry (Easton), 2018-08, Vol.57 (31), p.4651-4662

2018

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Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase

Journal of the American Chemical Society, 2015-12, Vol.137 (49), p.15342-15345

2015

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Transforming berberine into its intestine-absorbable form by the gut microbiota

Scientific reports, 2015-07, Vol.5 (1), p.12155-12155, Article 12155

2015

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Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

International journal of molecular sciences, 2024-06, Vol.25 (12), p.6593

2024

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Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

Chemical communications (Cambridge, England), 2015-08, Vol.51 (64), p.12787-12790

2015

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High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

Chemical communications (Cambridge, England), 2013-01, Vol.49 (25), p.2554-2556

2013

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A novel cold-adapted nitroreductase from Psychrobactersp. ANT206: Heterologous expression, characterization and nitrobenzene reduction capacity

Enzyme and microbial technology, 2019-12, Vol.131, p.109434-109434, Article 109434

2019

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The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism

FEBS letters, 2022-09, Vol.596 (18), p.2425-2440

2022

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A Lysosome-Targeting Fluorescence Off-On Probe for Imaging of Nitroreductase and Hypoxia in Live Cells

Chemistry, an Asian journal, 2016-10, Vol.11 (19), p.2719-2724

2016

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A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

Chemical communications (Cambridge, England), 2020-06, Vol.56 (51), p.6949-6952

2020

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Comparative analysis among the degradation potential of enzymes obtained from Escherichia coli against the toxicity of sulfur dyes through molecular docking

Zeitschrift für Naturforschung C. A journal of biosciences, 2024-07, Vol.79 (7-8), p.221-234

2024

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Pendimethalin Nitroreductase Is Responsible for the Initial Pendimethalin Degradation Step in Bacillus subtilis Y3

Applied and environmental microbiology, 2016-12, Vol.82 (24), p.7052-7062

2016

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The distribution and mechanism of iodotyrosine deiodinase defied expectations

Archives of biochemistry and biophysics, 2017-10, Vol.632, p.77-87

2017

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In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent 19 F NMR

Angewandte Chemie International Edition, 2022-12, Vol.61 (50), p.e202213495-e202213495

2022

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Electron competition among nitrogen oxides reduction during methanol-utilizing denitrification in wastewater treatment

Water research (Oxford), 2013-06, Vol.47 (10), p.3273-3281

2013

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Real time detection of live microbes using a highly sensitive bioluminescent nitroreductase probe

Chemical communications (Cambridge, England), 2015-03, Vol.51 (21), p.4440-4442

2015

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An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria

NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation

Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis

A Cofactor‐Substrate‐Based Supramolecular Fluorescent Probe for the Ultrafast Detection of Nitroreductase under Hypoxic Conditions

in vivo imaging and detection of nitroreductase in zebrafish by a new near-infrared fluorescence off–on probe

Reduction of polynitroaromatic compounds: the bacterial nitroreductases

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy

Biomimetic sensor based on molecularly imprinted polymer with nitroreductase-like activity for metronidazole detection

The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies

Revealing Unexplored Sequence-Function Space Using Sequence Similarity Networks

Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase

Transforming berberine into its intestine-absorbable form by the gut microbiota

Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

A novel cold-adapted nitroreductase from Psychrobactersp. ANT206: Heterologous expression, characterization and nitrobenzene reduction capacity

The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism

A Lysosome-Targeting Fluorescence Off-On Probe for Imaging of Nitroreductase and Hypoxia in Live Cells

A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

Comparative analysis among the degradation potential of enzymes obtained from Escherichia coli against the toxicity of sulfur dyes through molecular docking

Pendimethalin Nitroreductase Is Responsible for the Initial Pendimethalin Degradation Step in Bacillus subtilis Y3

The distribution and mechanism of iodotyrosine deiodinase defied expectations

In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent 19 F NMR

Electron competition among nitrogen oxides reduction during methanol-utilizing denitrification in wastewater treatment

Real time detection of live microbes using a highly sensitive bioluminescent nitroreductase probe

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