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Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

Biochemical journal, 2015-10, Vol.471 (2), p.131-153

2015

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Reduction of polynitroaromatic compounds: the bacterial nitroreductases

FEMS microbiology reviews, 2008-05, Vol.32 (3), p.474-500

2008

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Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2015-09, Vol.59 (9), p.5316-5323

2015

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A novel cold-adapted nitroreductase from Psychrobactersp. ANT206: Heterologous expression, characterization and nitrobenzene reduction capacity

Enzyme and microbial technology, 2019-12, Vol.131, p.109434-109434, Article 109434

2019

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NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation

Nature methods, 2022-02, Vol.19 (2), p.205-215

2022

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An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria

Angewandte Chemie International Edition, 2020-05, Vol.59 (22), p.8512-8516

International ed. in English, 2020

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Identification of Enterococcus faecalis enzymes with azoreductases and/or nitroreductase activity

BMC microbiology, 2017-05, Vol.17 (1), p.126-126, Article 126

2017

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The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies

International journal of molecular sciences, 2024-04, Vol.25 (8), p.4413

2024

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Biochemical, kinetic, and structural characterization of a Bacillus tequilensis nitroreductase

The FEBS journal, 2024-09, Vol.291 (17), p.3889-3903

2024

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Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy

Cell chemical biology, 2017-03, Vol.24 (3), p.391-403

2017

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A Cofactor‐Substrate‐Based Supramolecular Fluorescent Probe for the Ultrafast Detection of Nitroreductase under Hypoxic Conditions

Angewandte Chemie International Edition, 2020-04, Vol.59 (15), p.6021-6027

International ed. in English, 2020

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in vivo imaging and detection of nitroreductase in zebrafish by a new near-infrared fluorescence off–on probe

Biosensors & bioelectronics, 2015-01, Vol.63, p.112-116

2015

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Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases

Chemico-biological interactions, 2022-12, Vol.368, p.110222, Article 110222

2022

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Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

International journal of molecular sciences, 2024-06, Vol.25 (12), p.6593

2024

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A mitochondria-targeting nitroreductase fluorescent probe with large Stokes shift and long-wavelength emission for imaging hypoxic status in tumor cells

Analytica chimica acta, 2020-03, Vol.1103, p.202-211

2020

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Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

PLoS pathogens, 2020-02, Vol.16 (2), p.e1008287-e1008287

2020

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A new fluorescent probe with a large turn-on signal for imaging nitroreductase in tumor cells and tissues by two-photon microscopy

Biosensors & bioelectronics, 2017-03, Vol.89 (Pt 2), p.853-858

2017

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Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase

Journal of the American Chemical Society, 2015-12, Vol.137 (49), p.15342-15345

2015

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Exploiting Nitroreductases for the Tailored Photoenzymatic Synthesis of Structurally Diverse Heterocyclic Compounds

Chemistry : a European journal, 2024-10, Vol.30 (56), p.e202402380-n/a

2024

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Dual Enzyme-Locked Activation Reporter for Accurate Liver Cancer Surveillance

Analytical chemistry (Washington), 2024-07, Vol.96 (29), p.12074-12083

2024

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Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight

American journal of physiology. Renal physiology, 2024-09, Vol.327 (3), p.F463-F475

2024

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Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer

European journal of medicinal chemistry, 2020-02, Vol.187, p.111937, Article 111937

2020

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An efficient fluorescence sensor for nitroreductase selective imaging based on intramolecular photoinduced electron transfer

Talanta (Oxford), 2019-12, Vol.205, p.120133-120133, Article 120133

2019

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The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism

FEBS letters, 2022-09, Vol.596 (18), p.2425-2440

2022

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Efficient Two-Photon Fluorescent Probe for Nitroreductase Detection and Hypoxia Imaging in Tumor Cells and Tissues

Analytical chemistry (Washington), 2015-12, Vol.87 (23), p.11832-11839

2015

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Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

Reduction of polynitroaromatic compounds: the bacterial nitroreductases

Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis

A novel cold-adapted nitroreductase from Psychrobactersp. ANT206: Heterologous expression, characterization and nitrobenzene reduction capacity

NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation

An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria

Identification of Enterococcus faecalis enzymes with azoreductases and/or nitroreductase activity

The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies

Biochemical, kinetic, and structural characterization of a Bacillus tequilensis nitroreductase

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy

A Cofactor‐Substrate‐Based Supramolecular Fluorescent Probe for the Ultrafast Detection of Nitroreductase under Hypoxic Conditions

in vivo imaging and detection of nitroreductase in zebrafish by a new near-infrared fluorescence off–on probe

Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases

Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

A mitochondria-targeting nitroreductase fluorescent probe with large Stokes shift and long-wavelength emission for imaging hypoxic status in tumor cells

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

A new fluorescent probe with a large turn-on signal for imaging nitroreductase in tumor cells and tissues by two-photon microscopy

Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase

Exploiting Nitroreductases for the Tailored Photoenzymatic Synthesis of Structurally Diverse Heterocyclic Compounds

Dual Enzyme-Locked Activation Reporter for Accurate Liver Cancer Surveillance

Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight

Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer

An efficient fluorescence sensor for nitroreductase selective imaging based on intramolecular photoinduced electron transfer

The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism

Efficient Two-Photon Fluorescent Probe for Nitroreductase Detection and Hypoxia Imaging in Tumor Cells and Tissues

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