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Unexpected link between an antibiotic, pannexin channels and apoptosis

Nature (London), 2014-03, Vol.507 (7492), p.329-334

2014

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Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood

Journal of pharmaceutical and biomedical analysis, 2024-08, Vol.245, p.116154-116154, Article 116154

2024

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A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies

Investigational new drugs, 2016-04, Vol.34 (2), p.184-192

2016

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REVEAL‐1, a phase 2 dose regimen optimization study of vosaroxin in older poor‐risk patients with previously untreated acute myeloid leukaemia

British journal of haematology, 2015-03, Vol.168 (6), p.796-805

2015

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Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe

Analytical methods, 2024-04, Vol.16 (16), p.2556-2568

2024

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Pharmacokinetic and metabolic analysis of an Alzheimer's disease therapeutic in rat serum via microfluidic CZE–MS

Biomedical chromatography, 2022-01, Vol.36 (1), p.e5243-n/a

2022

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Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5683), p.528-532

2004

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Pharmacokinetics of the Novel, Selective, Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone in Healthy Volunteers: Results from an Absolute Bioavailability Study and Drug–Drug Interaction Studies In Vitro and In Vivo

European journal of drug metabolism and pharmacokinetics, 2018-12, Vol.43 (6), p.715-727

2018

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In Vivo Pharmacodynamic Target Investigation of Two Bacterial Topoisomerase Inhibitors, ACT-387042 and ACT-292706, in the Neutropenic Murine Thigh Model against Streptococcus pneumoniae and Staphylococcus aureus

Antimicrobial agents and chemotherapy, 2016-06, Vol.60 (6), p.3626-3632

2016

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The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique

Drug design, development and therapy, 2021-01, Vol.15, p.4865-4873

2021

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Metabolism and disposition of the anticancer quinolone derivative vosaroxin, a novel inhibitor of topoisomerase II

Investigational new drugs, 2017-08, Vol.35 (4), p.478-490

2017

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Using deconvolution to understand the mechanism for variable plasma concentration–time profiles after intramuscular injection

International journal of pharmaceutics, 2015-03, Vol.481 (1-2), p.71-78

2015

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Quantification of vosaroxin and its metabolites N-desmethylvosaroxin and O-desmethylvosaroxin in human plasma and urine using high-performance liquid chromatography-tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016-08, Vol.1027, p.1-10

2016

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A new approach for antibiotic drugs determination in human plasma by liquid chromatography–mass spectrometry

Journal of Chromatography A, 2013-01, Vol.1272 (11), p.41-49

2013

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HPTLC method for direct determination of gemifloxacin mesylate in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014-09, Vol.967, p.98-101

2014

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Mass balance and metabolism of the antimalarial pyronaridine in healthy volunteers

European journal of drug metabolism and pharmacokinetics, 2015-03, Vol.40 (1), p.75-86

2015

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Spectrofluorimetric Methods for the Determination of Gemifloxacin in Tablets and Spiked Plasma Samples

Journal of fluorescence, 2011-05, Vol.21 (3), p.1001-1007

2011

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Gemifloxacin mesylate (GFM): dissolution test based on in vivo data

Drug development and industrial pharmacy, 2015-04, Vol.41 (4), p.567-572

2015

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Competitive Inhibition of Renal Tubular Secretion of Gemifloxacin by Probenecid

Antimicrobial Agents and Chemotherapy, 2009-09, Vol.53 (9), p.3902-3907

2009

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Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug

Xenobiotica, 2013-04, Vol.43 (4), p.355-367

2013

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Chemiluminescence determination of gemifloxacin based on diperiodatoargentate (III)-sulphuric acid reaction in a micellar medium

Luminescence (Chichester, England), 2013-03, Vol.28 (2), p.108-113

2013

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Validated liquid chromatographic-fluorescence method for the quantitation of gemifloxacin in human plasma

Talanta (Oxford), 2010-11, Vol.83 (1), p.110-116

2010

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Determination of gemifloxacin on dried blood spots by hydrophilic interaction liquid chromatography with fluorescence detector: application to pharmacokinetics in rats

Biomedical chromatography, 2012-12, Vol.26 (12), p.1534-1542

2012

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Reversed phase liquid chromatography method with fluorescence detection of gemifloxacin in rat plasma and its application to the pharmacokinetic study

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011-11, Vol.879 (30), p.3639-3644

2011

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A rapid LC–MS/MS method for the quantitation of a series of benzonaphthyridine derivatives: Application to in vivo pharmacokinetic and lipophilicity studies in drug development

Journal of pharmaceutical and biomedical analysis, 2012-04, Vol.63, p.9-16

2012

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Unexpected link between an antibiotic, pannexin channels and apoptosis

Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood

A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies

REVEAL‐1, a phase 2 dose regimen optimization study of vosaroxin in older poor‐risk patients with previously untreated acute myeloid leukaemia

Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe

Pharmacokinetic and metabolic analysis of an Alzheimer's disease therapeutic in rat serum via microfluidic CZE–MS

Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

Pharmacokinetics of the Novel, Selective, Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone in Healthy Volunteers: Results from an Absolute Bioavailability Study and Drug–Drug Interaction Studies In Vitro and In Vivo

In Vivo Pharmacodynamic Target Investigation of Two Bacterial Topoisomerase Inhibitors, ACT-387042 and ACT-292706, in the Neutropenic Murine Thigh Model against Streptococcus pneumoniae and Staphylococcus aureus

The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique

Metabolism and disposition of the anticancer quinolone derivative vosaroxin, a novel inhibitor of topoisomerase II

Using deconvolution to understand the mechanism for variable plasma concentration–time profiles after intramuscular injection

Quantification of vosaroxin and its metabolites N-desmethylvosaroxin and O-desmethylvosaroxin in human plasma and urine using high-performance liquid chromatography-tandem mass spectrometry

A new approach for antibiotic drugs determination in human plasma by liquid chromatography–mass spectrometry

HPTLC method for direct determination of gemifloxacin mesylate in human plasma

Mass balance and metabolism of the antimalarial pyronaridine in healthy volunteers

Spectrofluorimetric Methods for the Determination of Gemifloxacin in Tablets and Spiked Plasma Samples

Gemifloxacin mesylate (GFM): dissolution test based on in vivo data

Competitive Inhibition of Renal Tubular Secretion of Gemifloxacin by Probenecid

Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug

Chemiluminescence determination of gemifloxacin based on diperiodatoargentate (III)-sulphuric acid reaction in a micellar medium

Validated liquid chromatographic-fluorescence method for the quantitation of gemifloxacin in human plasma

Determination of gemifloxacin on dried blood spots by hydrophilic interaction liquid chromatography with fluorescence detector: application to pharmacokinetics in rats

Reversed phase liquid chromatography method with fluorescence detection of gemifloxacin in rat plasma and its application to the pharmacokinetic study

A rapid LC–MS/MS method for the quantitation of a series of benzonaphthyridine derivatives: Application to in vivo pharmacokinetic and lipophilicity studies in drug development

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