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Molecular mechanism of IKK catalytic dimer docking to NF-κB substrates

Nature communications, 2024-09, Vol.15 (1), p.7692-19, Article 7692

2024

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NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

Nature (London), 2020-02, Vol.578 (7795), p.461-466

2020

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Downregulation of Nogo-B ameliorates cerebral ischemia/reperfusion injury in mice through regulating microglia polarization via TLR4/NF-kappaB pathway

Neurochemistry international, 2023-07, Vol.167, p.105553-105553, Article 105553

2023

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Trans-anethole exerts protective effects on lipopolysaccharide-induced acute jejunal inflammation of broilers via repressing NF-κB signaling pathway

Poultry science, 2023-02, Vol.102 (2), p.102397-102397, Article 102397

2023

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Discovery of novel pyrazole derivatives as a potent anti‐inflammatory agent in RAW264.7 cells via inhibition of NF‐ĸB for possible benefit against SARS‐CoV‐2

Journal of biochemical and molecular toxicology, 2021-03, Vol.35 (3), p.e22656-n/a

2021

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Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation

Nucleic acids research, 2021-11, Vol.49 (19), p.11211-11223

2021

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Dihydroartemisinin Increases the Sensitivity of Photodynamic Therapy Via NF-κB/HIF-1α/VEGF Pathway in Esophageal Cancer Cell in vitro and in vivo

Cellular physiology and biochemistry, 2018-01, Vol.48 (5), p.2035-2045

2018

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Cornuside, by regulating the AGEs‐RAGE‐IκBα‐ERK1/2 signaling pathway, ameliorates cognitive impairment associated with brain aging

Phytotherapy research, 2023-06, Vol.37 (6), p.2419-2436

2023

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Cinnamaldehyde Ameliorates Dextran Sulfate Sodium‐Induced Colitis in Mice by Modulating TLR4/NF‐κB Signaling Pathway and NLRP3 Inflammasome Activation

Chemistry & biodiversity, 2023-02, Vol.20 (2), p.e202200089-n/a

2023

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Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway

Neuroimmunomodulation, 2022, Vol.29 (4), p.486-492

2022

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Oxidative Stress

Annual review of biochemistry, 2017-06, Vol.86 (1), p.715-748

2017

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Development of mKO2 fusion proteins for real-time imaging and mechanistic investigation of the degradation kinetics of human IκBα in living cells

Biochimica et biophysica acta. Molecular cell research, 2019-02, Vol.1866 (2), p.190-198

2019

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Taurine supplementation regulates Iκ-Bα protein expression in adipose tissue and serum IL-4 and TNF-α concentrations in MSG obesity

European journal of nutrition, 2017-03, Vol.56 (2), p.705-713

2017

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Inhibitory effects of 3α-hydroxy-lup-20(29)-en-23, 28-dioic acid on lipopolysaccharide-induced TNF-α, IL-1β, and the high mobility group box 1 release in macrophages

Bioscience, biotechnology, and biochemistry, 2017-07, Vol.81 (7), p.1305-1313

2017

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NF-ĸβ upregulates ADAMTS5 expression by direct binding after TNF-α treatment in OUMS-27 chondrosarcoma cell line

Molecular biology reports, 2020-06, Vol.47 (6), p.4215-4223

2020

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NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages

Science (American Association for the Advancement of Science), 2021-06, Vol.372 (6548), p.1349-1353

2021

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Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation

Nature communications, 2019-04, Vol.10 (1), p.1604-1604, Article 1604

2019

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Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Nature communications, 2017-01, Vol.8 (1), p.14121-14121, Article 14121

2017

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Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

Science signaling, 2017-02, Vol.10 (465)

2017

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HMGB1 upregulates NF-kB by inhibiting IKB-α and associates with diabetic retinopathy

Life sciences (1973), 2020-01, Vol.241, p.117146-117146, Article 117146

2020

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Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality

Science advances, 2020-04, Vol.6 (15), p.eaaz6980

2020

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Anti-inflammatory and anti-excitoxic effects of diethyl oxopropanamide, an ethyl pyruvate bioisoster, exert robust neuroprotective effects in the postischemic brain

Scientific reports, 2017-02, Vol.7 (1), p.42891-42891, Article 42891

2017

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Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage

Autophagy, 2023-08, Vol.19 (8), p.2296-2317

2023

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lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer

Molecular cancer, 2020-02, Vol.19 (1), p.35-35, Article 35

2020

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Allantopyrone A interferes with multiple components of the TNF receptor 1 complex and blocks RIP1 modifications in the TNF-α-induced signaling pathway

Journal of antibiotics, 2017-09, Vol.70 (9), p.929-936

2017

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Molecular mechanism of IKK catalytic dimer docking to NF-κB substrates

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

Downregulation of Nogo-B ameliorates cerebral ischemia/reperfusion injury in mice through regulating microglia polarization via TLR4/NF-kappaB pathway

Trans-anethole exerts protective effects on lipopolysaccharide-induced acute jejunal inflammation of broilers via repressing NF-κB signaling pathway

Discovery of novel pyrazole derivatives as a potent anti‐inflammatory agent in RAW264.7 cells via inhibition of NF‐ĸB for possible benefit against SARS‐CoV‐2

Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation

Dihydroartemisinin Increases the Sensitivity of Photodynamic Therapy Via NF-κB/HIF-1α/VEGF Pathway in Esophageal Cancer Cell in vitro and in vivo

Cornuside, by regulating the AGEs‐RAGE‐IκBα‐ERK1/2 signaling pathway, ameliorates cognitive impairment associated with brain aging

Cinnamaldehyde Ameliorates Dextran Sulfate Sodium‐Induced Colitis in Mice by Modulating TLR4/NF‐κB Signaling Pathway and NLRP3 Inflammasome Activation

Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway

Oxidative Stress

Development of mKO2 fusion proteins for real-time imaging and mechanistic investigation of the degradation kinetics of human IκBα in living cells

Taurine supplementation regulates Iκ-Bα protein expression in adipose tissue and serum IL-4 and TNF-α concentrations in MSG obesity

Inhibitory effects of 3α-hydroxy-lup-20(29)-en-23, 28-dioic acid on lipopolysaccharide-induced TNF-α, IL-1β, and the high mobility group box 1 release in macrophages

NF-ĸβ upregulates ADAMTS5 expression by direct binding after TNF-α treatment in OUMS-27 chondrosarcoma cell line

NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages

Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

HMGB1 upregulates NF-kB by inhibiting IKB-α and associates with diabetic retinopathy

Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality

Anti-inflammatory and anti-excitoxic effects of diethyl oxopropanamide, an ethyl pyruvate bioisoster, exert robust neuroprotective effects in the postischemic brain

Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage

lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer

Allantopyrone A interferes with multiple components of the TNF receptor 1 complex and blocks RIP1 modifications in the TNF-α-induced signaling pathway

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