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Endothelial NADPH oxidases: which NOX to target in vascular disease?

Trends in endocrinology and metabolism, 2014-09, Vol.25 (9), p.452-463

2014

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Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Diabetologia, 2017-05, Vol.60 (5), p.927-937

2017

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Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling

Arteriosclerosis, thrombosis, and vascular biology, 2016-02, Vol.36 (2), p.295-307

2016

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ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis

American Journal of Physiology: Cell Physiology, 2017-06, Vol.312 (6), p.C749-C764

2017

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Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

PloS one, 2015-07, Vol.10 (7), p.e0129743

2015

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Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

Biochemistry (Easton), 2014-08, Vol.53 (31), p.5111-5120

2014

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Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Journal of the American Society of Nephrology, 2014-06, Vol.25 (6), p.1237-1254

2014

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NADPH Oxidases Are Essential for Macrophage Differentiation

The Journal of biological chemistry, 2016-09, Vol.291 (38), p.20030-20041

2016

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The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

The Journal of biological chemistry, 2011-04, Vol.286 (15), p.13304-13313

2011

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NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

Redox biology, 2014-01, Vol.2 (C), p.267-272

2014

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Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs

European journal of pharmacology, 2020-09, Vol.883, p.173314-173314, Article 173314

2020

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Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis

Arteriosclerosis, thrombosis, and vascular biology, 2016-05, Vol.36 (5), p.846-854

2016

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Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2

Proceedings of the National Academy of Sciences - PNAS, 2024-06, Vol.121 (23), p.e2320388121

2024

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Regulation of Nox and Duox enzymatic activity and expression

Free radical biology & medicine, 2007-08, Vol.43 (3), p.319-331

2007

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Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury

Journal of molecular and cellular cardiology, 2013-11, Vol.64, p.99-107

2013

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NADPH Oxidases Are Required for Full Platelet Activation In Vitro and Thrombosis In Vivo but Dispensable for Plasma Coagulation and Hemostasis

Arteriosclerosis, thrombosis, and vascular biology, 2021-02, Vol.41 (2), p.683-697

2021

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Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy

Hypertension (Dallas, Tex. 1979), 2020-04, Vol.75 (4), p.1091-1101

2020

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Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

Circulation research, 2012-04, Vol.110 (9), p.1217-1225

2012

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Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

Circulation research, 2013-02, Vol.112 (4), p.651-663

2013

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Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

Nature reviews. Drug discovery, 2011-06, Vol.10 (6), p.453-471

2011

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Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes

American journal of physiology. Renal physiology, 2015-06, Vol.308 (11), p.F1276-F1287

2015

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NADPH Oxidase 1 Mediates Acute Blood Pressure Response to Angiotensin II by Contributing to Calcium Influx in Vascular Smooth Muscle Cells

Arteriosclerosis, thrombosis, and vascular biology, 2022-05, Vol.42 (5), p.e117

2022

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Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies

Annals of medicine (Helsinki), 2012-06, Vol.44 (S1), p.S2-S16

2012

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ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

Oncogene, 2012-03, Vol.31 (9), p.1117-1129

2012

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CRISPR-gene-engineered CYBB knock-out PLB-985 cells, a useful model to study functional impact of X-linked chronic granulomatous disease mutations: application to the G412E X91+-CGD mutation

Clinical and experimental immunology, 2023-04, Vol.212 (2), p.156-165

2023

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Endothelial NADPH oxidases: which NOX to target in vascular disease?

Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling

ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

NADPH Oxidases Are Essential for Macrophage Differentiation

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs

Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis

Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2

Regulation of Nox and Duox enzymatic activity and expression

Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury

NADPH Oxidases Are Required for Full Platelet Activation In Vitro and Thrombosis In Vivo but Dispensable for Plasma Coagulation and Hemostasis

Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes

NADPH Oxidase 1 Mediates Acute Blood Pressure Response to Angiotensin II by Contributing to Calcium Influx in Vascular Smooth Muscle Cells

Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

CRISPR-gene-engineered CYBB knock-out PLB-985 cells, a useful model to study functional impact of X-linked chronic granulomatous disease mutations: application to the G412E X91+-CGD mutation

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