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Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (7), p.3535-3542

2020

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Regulation of the MLH1-MLH3 endonuclease in meiosis

Nature (London), 2020-10, Vol.586 (7830), p.618-622

2020

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Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair

PLoS genetics, 2017-05, Vol.13 (5), p.e1006722-e1006722

2017

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The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

PLoS biology, 2017-04, Vol.15 (4), p.e2001164-e2001164

2017

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Mechanistic View and Genetic Control of DNA Recombination during Meiosis

Molecular cell, 2018-04, Vol.70 (1), p.9-20.e6

2018

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The Dmc1 recombinase physically interacts with and promotes the meiotic crossover functions of the Mlh1-Mlh3 endonuclease

Genetics (Austin), 2024-07, Vol.227 (3)

2024

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Insights into DNA cleavage by MutL homologs from analysis of conserved motifs in eukaryotic Mlh1

BioEssays, 2023-09, Vol.45 (9), p.e2300031-n/a

2023

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Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease

American journal of human genetics, 2024-06, Vol.111 (6), p.1165-1183

2024

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HDAC6 regulates DNA damage response via deacetylating MLH1

The Journal of biological chemistry, 2019-04, Vol.294 (15), p.5813-5826

2019

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Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer

Nature communications, 2021-05, Vol.12 (1), p.2940-11, Article 2940

2021

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Extracellular vesicles transmitted miR‐31‐5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma

International journal of cancer, 2020-02, Vol.146 (4), p.1052-1063

2020

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GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one

Nucleic acids research, 2018-05, Vol.46 (8), p.4022-4032

2018

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Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer

Journal of clinical oncology, 2017-04, Vol.35 (10), p.1086-1095

2017

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OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice

Journal of genetics and genomics, 2021-06, Vol.48 (6), p.485-496

2021

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Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

eLife, 2019-11, Vol.8

2019

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Expanded roles for the MutL family of DNA mismatch repair proteins

Yeast (Chichester, England), 2021-01, Vol.38 (1), p.39-53

2021

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Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair

Nature (London), 2016-11, Vol.539 (7630), p.583-587

2016

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Dynamic human MutSα–MutLα complexes compact mismatched DNA

Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (28), p.16302-16312

2020

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Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex

Nucleic acids research, 2019-02, Vol.47 (4), p.1823

2019

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Lessons learnt from implementation of a Lynch syndrome screening program for patients with gynaecological malignancy

Pathology, 2017-08, Vol.49 (5), p.457-464

2017

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Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture)

Angewandte Chemie (International ed.), 2016-07, Vol.55 (30), p.8490-8501

Modrich, Paul

International ed. in English, 2016

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Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

eLife, 2019-06, Vol.8

2019

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MutL Activates UvrD by Interaction Between the MutL C-terminal Domain and the UvrD 2B Domain

Journal of molecular biology, 2024-06, Vol.436 (11), p.168589-168589, Article 168589

2024

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Phosphorylation‐dependent signaling controls degradation of DNA mismatch repair protein PMS2

Molecular carcinogenesis, 2017-12, Vol.56 (12), p.2663-2668

2017

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Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

Regulation of the MLH1-MLH3 endonuclease in meiosis

Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

Mechanistic View and Genetic Control of DNA Recombination during Meiosis

The Dmc1 recombinase physically interacts with and promotes the meiotic crossover functions of the Mlh1-Mlh3 endonuclease

Insights into DNA cleavage by MutL homologs from analysis of conserved motifs in eukaryotic Mlh1

Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease

HDAC6 regulates DNA damage response via deacetylating MLH1

Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer

Extracellular vesicles transmitted miR‐31‐5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma

GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one

Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer

OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Expanded roles for the MutL family of DNA mismatch repair proteins

Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair

Dynamic human MutSα–MutLα complexes compact mismatched DNA

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex

Lessons learnt from implementation of a Lynch syndrome screening program for patients with gynaecological malignancy

Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture)

Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

MutL Activates UvrD by Interaction Between the MutL C-terminal Domain and the UvrD 2B Domain

Phosphorylation‐dependent signaling controls degradation of DNA mismatch repair protein PMS2

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