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Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (7), p.3535-3542

2020

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Extracellular vesicles transmitted miR‐31‐5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma

International journal of cancer, 2020-02, Vol.146 (4), p.1052-1063

2020

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The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

PLoS biology, 2017-04, Vol.15 (4), p.e2001164-e2001164

2017

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Correlation of MLH1 polymorphisms, survival statistics, in silico assessment and gene downregulation with clinical outcomes among breast cancer cases

Molecular biology reports, 2020, Vol.47 (1), p.683-692

2020

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Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair

PLoS genetics, 2017-05, Vol.13 (5), p.e1006722-e1006722

2017

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Identification of a novel pathogenic MLH1 mutation and recommended genetic screening strategy: An investigation of three Chinese Lynch syndrome pedigrees

Molecular genetics & genomic medicine, 2020-08, Vol.8 (8), p.e1295-n/a

2020

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MLH1 deficiency leads to deregulated mitochondrial metabolism

Cell death & disease, 2019-10, Vol.10 (11), p.795-11, Article 795

2019

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Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations

Familial cancer, 2018-04, Vol.17 (2), p.225-228

2018

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Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer

Journal of clinical oncology, 2017-04, Vol.35 (10), p.1086-1095

2017

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Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells

Nucleic acids research, 2017-02, Vol.45 (3), p.1219

2017

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Reduced microRNA‐188‐3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia

Cell proliferation, 2017-02, Vol.50 (1), p.np-n/a

2017

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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

Cancer cell, 2021-01, Vol.39 (1), p.109-121.e5

2021

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Epigenetic Silencing of the MLH1 Promoter in Relation to the Development of Gastric Cancer and its use as a Biomarker for Patients with Microsatellite Instability: a Systematic Analysis

Cellular physiology and biochemistry, 2018-02, Vol.45 (1), p.148-162

2018

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Regulation of the MLH1-MLH3 endonuclease in meiosis

Nature (London), 2020-10, Vol.586 (7830), p.618-622

2020

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Loss of MLH1 sensitizes colon cancer cells to DNA‐PKcs inhibitor KU60648

Molecular carcinogenesis, 2017-07, Vol.56 (7), p.1816-1824

2017

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Clinical Management and Tumor Surveillance Recommendations of Inherited Mismatch Repair Deficiency in Childhood

Clinical cancer research, 2017-06, Vol.23 (11), p.e32-e37

2017

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A “Two-in-One Hit” Model of Shortcut Carcinogenesis in MLH1 Lynch Syndrome Carriers

Gastroenterology (New York, N.Y. 1943), 2023-07, Vol.165 (1), p.267-270.e4

2023

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Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and MLH1 methylation improved the diagnosis of Lynch syndrome across the population?

Cancer, 2019-09, Vol.125 (18), p.3172-3183

2019

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A modifier of Huntington's disease onset at the MLH1 locus

Human molecular genetics, 2017-10, Vol.26 (19), p.3859-3867

2017

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Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases

Cellular and molecular life sciences : CMLS, 2016-12, Vol.73 (24), p.4739-4748

2016

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Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas

Medical science monitor, 2017-02, Vol.23, p.938-947

2017

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Comparison between Mononucleotide and Dinucleotide Marker Panels in Gastric Cancer with Loss of hMLH1 or hMSH2 Expression

The International journal of biological markers, 2017-07, Vol.32 (3), p.352-356

2017

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Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers

Genome research, 2018-05, Vol.28 (5), p.666

2018

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An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes

Modern pathology, 2022-03, Vol.35 (3), p.427-437

2022

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Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

Extracellular vesicles transmitted miR‐31‐5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

Correlation of MLH1 polymorphisms, survival statistics, in silico assessment and gene downregulation with clinical outcomes among breast cancer cases

Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair

Identification of a novel pathogenic MLH1 mutation and recommended genetic screening strategy: An investigation of three Chinese Lynch syndrome pedigrees

MLH1 deficiency leads to deregulated mitochondrial metabolism

Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations

Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer

Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells

Reduced microRNA‐188‐3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

Epigenetic Silencing of the MLH1 Promoter in Relation to the Development of Gastric Cancer and its use as a Biomarker for Patients with Microsatellite Instability: a Systematic Analysis

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Regulation of the MLH1-MLH3 endonuclease in meiosis

Loss of MLH1 sensitizes colon cancer cells to DNA‐PKcs inhibitor KU60648

Clinical Management and Tumor Surveillance Recommendations of Inherited Mismatch Repair Deficiency in Childhood

A “Two-in-One Hit” Model of Shortcut Carcinogenesis in MLH1 Lynch Syndrome Carriers

Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and MLH1 methylation improved the diagnosis of Lynch syndrome across the population?

A modifier of Huntington's disease onset at the MLH1 locus

Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases

Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas

Comparison between Mononucleotide and Dinucleotide Marker Panels in Gastric Cancer with Loss of hMLH1 or hMSH2 Expression

Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers

An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes

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